Q14240: Eukaryotic initiation factor 4A-II

General Information

Protein names	- Eukaryotic initiation factor 4A-II - eIF-4A-II - eIF4A-II - 3.6.4.13 - ATP-dependent RNA helicase eIF4A-2
Gene names	EIF4A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14240

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGGSADYNR EHGGPEGMDP DGVIESNWNE IVDNFDDMNL KESLLRGIYA YGFEKPSAIQ
        70         80         90        100        110        120
QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIEFK ETQALVLAPT RELAQQIQKV
       130        140        150        160        170        180
ILALGDYMGA TCHACIGGTN VRNEMQKLQA EAPHIVVGTP GRVFDMLNRR YLSPKWIKMF
       190        200        210        220        230        240
VLDEADEMLS RGFKDQIYEI FQKLNTSIQV VLLSATMPTD VLEVTKKFMR DPIRILVKKE
       250        260        270        280        290        300
ELTLEGIKQF YINVEREEWK LDTLCDLYET LTITQAVIFL NTRRKVDWLT EKMHARDFTV
       310        320        330        340        350        360
SALHGDMDQK ERDVIMREFR SGSSRVLITT DLLARGIDVQ QVSLVINYDL PTNRENYIHR
       370        380        390        400
IGRGGRFGRK GVAINFVTEE DKRILRDIET FYNTTVEEMP MNVADLI

Isoforms

- Isoform 2 of Eukaryotic initiation factor 4A-II

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14240-1-unknown	MSGGSA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14240-2-acetylation	SGGSAD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q14240-2-acetylation	SGGSAD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14240-2-acetylation	SGGSAD...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q14240-22-unknown	GVIESN...	22			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14240-22-unknown	GVIESN...	22		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161685
Q14240-22-	GVIESN...	22			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q14240-22-	GVIESN...	22			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14240-22-	GVIESN...	22			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14240-151-unknown	EAPHIV...	151		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19509
Q14240-151-unknown	EAPHIV...	151		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144808

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QKLQAE	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19509
...QKLQAE	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128084
...VADLI	407	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VADLI	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73160

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	150	LQAE.\|.EAPH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)