P55036: 26S proteasome non-ATPase regulatory subunit 4

General Information

Protein names	- 26S proteasome non-ATPase regulatory subunit 4 - 26S proteasome regulatory subunit RPN10 - 26S proteasome regulatory subunit S5A - Antisecretory factor 1 - AF - ASF - Multiubiquitin chain-binding protein
Gene names	PSMD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P55036

9 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV
        70         80         90        100        110        120
LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN
       130        140        150        160        170        180
EKDLVKLAKR LKKEKVNVDI INFGEEEVNT EKLTAFVNTL NGKDGTGSHL VTVPPGPSLA
       190        200        210        220        230        240
DALISSPILA GEGGAMLGLG ASDFEFGVDP SADPELALAL RVSMEEQRQR QEEEARRAAA
       250        260        270        280        290        300
ASAAEAGIAT TGTEDSDDAL LKMTISQQEF GRTGLPDLSS MTEEEQIAYA MQMSLQGAEF
       310        320        330        340        350        360
GQAESADIDA SSAMDTSEPA KEEDDYDVMQ DPEFLQSVLE NLPGVDPNNE AIRNAMGSLA
       370
SQATKDGKKD KKEEDKK

Isoforms

- Isoform Rpn10E of 26S proteasome non-ATPase regulatory subunit 4

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P55036-1-unknown	MVLEST...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55036-1-unknown	MVLEST...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86393
P55036-2-	VLESTM...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P55036-2-	VLESTM...	2		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P55036-2-	VLESTM...	2		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55036-2-unknown	VLESTM...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P55036-2-unknown	VLESTM...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P55036-2-unknown	VLESTM...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162348
P55036-31-unknown	DAVNIV...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19208
P55036-31-unknown	DAVNIV...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17737
P55036-31-unknown	DAVNIV...	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137582
P55036-112-	FVGSPV...	112		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55036-112-	FVGSPV...	112		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P55036-112-unknown	FVGSPV...	112	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3865
P55036-112-unknown	FVGSPV...	112	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143042
P55036-115-unknown	SPVEDN...	115	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7577
P55036-115-unknown	SPVEDN...	115	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143244
P55036-207-	GVDPSA...	207		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55036-207-unknown	GVDPSA...	207	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175421

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LQAQQD	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19208
...LQAQQD	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17737
...LQAQQD	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120571
...MRIIAF	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3865
...MRIIAF	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt126261
...IAFVGS	114	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7577
...IAFVGS	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt126472
...EEDKK	377	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EEDKK	377		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EEDKK	377		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EEDKK	377		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EEDKK	377		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	30	AQQD.\|.DAVN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	30	AQQD.\|.DAVN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	111	IIAF.\|.FVGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	114	FVGS.\|.SPVE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)