P43487: Ran-specific GTPase-activating protein

General Information

Protein names	- Ran-specific GTPase-activating protein - Ran-binding protein 1 - RanBP1
Gene names	RANBP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P43487

20 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAKDTHED HDTSTENTDE SNHDPQFEPI VSLPEQEIKT LEEDEEELFK MRAKLFRFAS
        70         80         90        100        110        120
ENDLPEWKER GTGDVKLLKH KEKGAIRLLM RRDKTLKICA NHYITPMMEL KPNAGSDRAW
       130        140        150        160        170        180
VWNTHADFAD ECPKPELLAI RFLNAENAQK FKTKFEECRK EIEEREKKAG SGKNDHAEKV
       190        200
AEKLEALSVK EETKEDAEEK Q

Isoforms

- Isoform 2 of Ran-specific GTPase-activating protein

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

20 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P43487-2-unknown	MAAAKD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P43487-2-	AAAKDT...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43487-2-Acetylation	AAAKDT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P43487-2-Acetylation	AAAKDT...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P43487-3-	AAKDTH...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43487-13-	TSTENT...	13			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43487-13-	TSTENT...	13			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43487-20-	ESNHDP...	20			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43487-21-	SNHDPQ...	21			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43487-23-	HDPQFE...	23			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43487-23-	HDPQFE...	23			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43487-30-unknown	IVSLPE...	30			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P43487-30-	IVSLPE...	30			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P43487-30-	IVSLPE...	30			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43487-30-	IVSLPE...	30			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43487-51-unknown	MRAKLF...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404126
P43487-51-unknown	MRAKLF...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000400940
P43487-51-unknown	MRAKLF...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404298
P43487-51-unknown	MRAKLF...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413502
P43487-58-	FASEND...	58			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P43487-58-	FASEND...	58			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43487-58-	FASEND...	58			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43487-58-	FASEND...	58			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P43487-107-unknown	MMELKP...	107			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P43487-107-	MMELKP...	107			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P43487-107-	MMELKP...	107			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43487-123-unknown	NTHADF...	123		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7468
P43487-123-unknown	NTHADF...	123		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5875
P43487-124-unknown	THADFA...	124		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5876
P43487-130-unknown	DECPKP...	130		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19107
P43487-130-unknown	DECPKP...	130		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17649
P43487-133-	PKPELL...	133			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P43487-180-	VAEKLE...	180			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P43487-188-	SVKEET...	188			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43487-188-	SVKEET...	188			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GAIRLL	88	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404724
...CANHYI	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404126
...CANHYI	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400940
...RAWVWN	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7468
...RAWVWN	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5875
...AWVWNT	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5876
...HADFAD	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19107
...HADFAD	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17649
...ETKEDA	196	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413502
...AEEKQ	201	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	122	WVWN.\|.NTHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	122	WVWN.\|.NTHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	123	VWNT.\|.THAD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	129	DFAD.\|.DECP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	129	DFAD.\|.DECP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)