Q96I25: Splicing factor 45

General Information

Protein names	- Splicing factor 45 - 45 kDa-splicing factor - RNA-binding motif protein 17
Gene names	RBM17
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96I25

8 N-termini

9 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLYDDLGVE TSDSKTEGWS KNFKLLQSQL QVKKAALTQA KSQRTKQSTV LAPVIDLKRG
        70         80         90        100        110        120
GSSDDRQIVD TPPHVAAGLK DPVPSGFSAG EVLIPLADEY DPMFPNDYEK VVKRQREERQ
       130        140        150        160        170        180
RQRELERQKE IEEREKRRKD RHEASGFARR PDPDSDEDED YERERRKRSM GGAAIAPPTS
       190        200        210        220        230        240
LVEKDKELPR DFPYEEDSRP RSQSSKAAIP PPVYEEQDRP RSPTGPSNSF LANMGGTVAH
       250        260        270        280        290        300
KIMQKYGFRE GQGLGKHEQG LSTALSVEKT SKRGGKIIVG DATEKDASKK SDSNPLTEIL
       310        320        330        340        350        360
KCPTKVVLLR NMVGAGEVDE DLEVETKEEC EKYGKVGKCV IFEIPGAPDD EAVRIFLEFE
       370        380        390        400
RVESAIKAVV DLNGRYFGGR VVKACFYNLD KFRVLDLAEQ V

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 9 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96I25-2-unknown	MSLYDD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96I25-2-Acetylation	SLYDDL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96I25-2-Acetylation	SLYDDL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q96I25-22-unknown	NFKLLQ...	22			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96I25-71-unknown	TPPHVA...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19738
Q96I25-175-unknown	IAPPTS...	175		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18077
Q96I25-242-	IMQKYG...	242			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q96I25-282-unknown	ATEKDA...	282		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13072
Q96I25-322-unknown	LEVETK...	322		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13073

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RQIVDT	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19738
...MGGAAI	174	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18077
...AIPPPV	212	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000402303
...DRPRSP	222	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408214
...EKTSKR	272	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000395448
...IIVGDA	281	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13072
...EVDEDL	321	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13073
...LAEQV	401	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LAEQV	401		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LAEQV	401		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LAEQV	401		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LAEQV	401		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	70	IVDT.\|.TPPH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	174	GAAI.\|.IAPP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	281	VGDA.\|.ATEK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	321	DEDL.\|.LEVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)