P05787: Keratin, type II cytoskeletal 8

General Information

Protein names	- Keratin, type II cytoskeletal 8 - Cytokeratin-8 - CK-8 - Keratin-8 - K8 - Type-II keratin Kb8
Gene names	KRT8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05787

11 N-termini

12 C-termini

13 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSIRVTQKSY KVSTSGPRAF SSRSYTSGPG SRISSSSFSR VGSSNFRGGL GGGYGGASGM
        70         80         90        100        110        120
GGITAVTVNQ SLLSPLVLEV DPNIQAVRTQ EKEQIKTLNN KFASFIDKVR FLEQQNKMLE
       130        140        150        160        170        180
TKWSLLQQQK TARSNMDNMF ESYINNLRRQ LETLGQEKLK LEAELGNMQG LVEDFKNKYE
       190        200        210        220        230        240
DEINKRTEME NEFVLIKKDV DEAYMNKVEL ESRLEGLTDE INFLRQLYEE EIRELQSQIS
       250        260        270        280        290        300
DTSVVLSMDN SRSLDMDSII AEVKAQYEDI ANRSRAEAES MYQIKYEELQ SLAGKHGDDL
       310        320        330        340        350        360
RRTKTEISEM NRNISRLQAE IEGLKGQRAS LEAAIADAEQ RGELAIKDAN AKLSELEAAL
       370        380        390        400        410        420
QRAKQDMARQ LREYQELMNV KLALDIEIAT YRKLLEGEES RLESGMQNMS IHTKTTSGYA
       430        440        450        460        470        480
GGLSSAYGGL TSPGLSYSLG SSFGSGAGSS SFSRTSSSRA VVVKKIETRD GKLVSESSDV

LPK

Isoforms

- Isoform 2 of Keratin, type II cytoskeletal 8

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 12 C-termini - 13 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05787-1-unknown	MSIRVT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05787-1-unknown	MSIRVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101525
P05787-77-unknown	VLEVDP...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13917
P05787-77-unknown	VLEVDP...	77	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142644
P05787-174-unknown	DFKNKY...	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18486
P05787-174-unknown	DFKNKY...	174	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146625
P05787-257-unknown	DSIIAE...	257	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18488
P05787-257-unknown	DSIIAE...	257	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149463
P05787-258-unknown	SIIAEV...	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11052
P05787-258-unknown	SIIAEV...	258	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149481
P05787-276-unknown	AEAESM...	276	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17121
P05787-276-unknown	AEAESM...	276	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149993
P05787-278-unknown	AESMYQ...	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18490
P05787-278-unknown	AESMYQ...	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17123
P05787-278-unknown	AESMYQ...	278	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150025
P05787-287-unknown	EELQSL...	287	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18492
P05787-287-unknown	EELQSL...	287	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17125
P05787-287-unknown	EELQSL...	287	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150219
P05787-319-unknown	AEIEGL...	319	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18494
P05787-319-unknown	AEIEGL...	319	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17127
P05787-319-unknown	AEIEGL...	319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150885
P05787-342-unknown	GELAIK...	342	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18496
P05787-342-unknown	GELAIK...	342	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151408
P05787-348-unknown	DANAKL...	348	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18498
P05787-348-unknown	DANAKL...	348	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151533

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LLSPLV	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13917
...LLSPLV	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125842
...QGLVED	173	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18486
...QGLVED	173	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129933
...RSLDMD	256	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18488
...RSLDMD	256	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132848
...SLDMDS	257	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11052
...SLDMDS	257	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132865
...ANRSRA	275	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17121
...ANRSRA	275	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133385
...RSRAEA	277	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18490
...RSRAEA	277	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17123
...RSRAEA	277	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133417
...YQIKYE	286	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18492
...YQIKYE	286	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17125
...YQIKYE	286	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133613
...ISRLQA	318	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18494
...ISRLQA	318	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17127
...ISRLQA	318	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134287
...DAEQRG	341	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18496
...DAEQRG	341	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134810
...ELAIKD	347	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18498
...ELAIKD	347	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134938
...DVLPK	483	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DVLPK	483	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt74101
...DVLPK	483		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DVLPK	483		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DVLPK	483		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DVLPK	483		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	76	SPLV.\|.VLEV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	173	LVED.\|.DFKN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	256	LDMD.\|.DSII	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	257	DMDS.\|.SIIA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1A_HUMAN	275	RSRA.\|.AEAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	277	RAEA.\|.AESM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	277	RAEA.\|.AESM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	286	IKYE.\|.EELQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	286	IKYE.\|.EELQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	318	RLQA.\|.AEIE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	318	RLQA.\|.AEIE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	341	EQRG.\|.GELA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	347	AIKD.\|.DANA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)