P07195: L-lactate dehydrogenase B chain

General Information

Protein names	- L-lactate dehydrogenase B chain - LDH-B - 1.1.1.27 - LDH heart subunit - LDH-H - Renal carcinoma antigen NY-REN-46
Gene names	LDHB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07195

7 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA LVDVLEDKLK
        70         80         90        100        110        120
GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF
       130        140        150        160        170        180
IIPQIVKYSP DCIIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG
       190        200        210        220        230        240
IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY
       250        260        270        280        290        300
EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG
       310        320        330
LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07195-2-unknown	MATLKE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07195-2-Acetylation	ATLKEK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07195-2-Acetylation	ATLKEK...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P07195-81-unknown	DKDYSV...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5432
P07195-81-unknown	DKDYSV...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18546
P07195-214-unknown	ELNPEM...	214		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7215
P07195-214-unknown	ELNPEM...	214		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5433
P07195-288-acetylation	VFLSLP...	288	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P07195-319-unknown	KSADTL...	319		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5434
P07195-320-	SADTLW...	320			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PKIVAD	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5432
...PKIVAD	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18546
...GVRQQE	102	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442680
...CIIIVV	136	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398015
...GVSLQE	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7215
...GVSLQE	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5433
...WKEVHK	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000379385
...VAQLKK	318	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5434
...DLKDL	334	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	80	IVAD.\|.DKDY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	80	IVAD.\|.DKDY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	213	SLQE.\|.ELNP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	213	SLQE.\|.ELNP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	318	QLKK.\|.KSAD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)