P14618: Pyruvate kinase PKM

General Information

Protein names	- Pyruvate kinase PKM - 2.7.1.40 - Cytosolic thyroid hormone-binding protein - CTHBP - Opa-interacting protein 3 - OIP-3 - Pyruvate kinase 2/3 - Pyruvate kinase muscle isozyme - Thyroid hormone-binding protein 1 - THBP1 - Tumor M2-PK - p58
Gene names	PKM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P14618

48 N-termini

19 C-termini

32 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform M1 of Pyruvate kinase PKM - Isoform 3 of Pyruvate kinase PKM

Sequence View

        10         20         30         40         50         60
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVET
        70         80         90        100        110        120
LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS DPILYRPVAV ALDTKGPEIR
       130        140        150        160        170        180
TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL
       190        200        210        220        230        240
ISLQVKQKGA DFLVTEVENG GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV
       250        260        270        280        290        300
FASFIRKASD VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE
       310        320        330        340        350        360
IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN AVLDGADCIM
       370        380        390        400        410        420
LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR LAPITSDPTE ATAVGAVEAS
       430        440        450        460        470        480
FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI IAVTRNPQTA RQAHLYRGIF PVLCKDPVQE
       490        500        510        520        530
AWAEDVDLRV NFAMNVGKAR GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P         10         20         30         40         50         60
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVET
        70         80         90        100        110        120
LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS DPILYRPVAV ALDTKGPEIR
       130        140        150        160        170        180
TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL
       190        200        210        220        230        240
ISLQVKQKGA DFLVTEVENG GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV
       250        260        270        280        290        300
FASFIRKASD VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE
       310        320        330        340        350        360
IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN AVLDGADCIM
       370        380        390        400        410        420
LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR LAPITSDPTE ATAVGAVEAS
       430        440        450        460        470        480
FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI IAVTRNPQTA RQAHLYRGIF PVLCKDPVQE
       490        500        510        520        530
AWAEDVDLRV NFAMNVGKAR GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

48 N-termini - 19 C-termini - 32 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P14618-2-unknown	MSKPHS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14618-1-unknown	MSKPHS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79222
P14618-2-Acetylation	SKPHSE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14618-2-Acetylation	SKPHSE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110670
P14618-6-unknown	SEAGTA...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18732
P14618-6-unknown	SEAGTA...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17337
P14618-6-unknown	SEAGTA...	6		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194727
P14618-7-unknown	EAGTAF...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18733
P14618-7-unknown	EAGTAF...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17338
P14618-7-unknown	EAGTAF...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194763
P14618-20-unknown	AAMADT...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17339
P14618-20-unknown	AAMADT...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136877
P14618-21-unknown	AMADTF...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18734
P14618-21-unknown	AMADTF...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17341
P14618-21-unknown	AMADTF...	21		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136903
P14618-23-unknown	ADTFLE...	23		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18736
P14618-23-unknown	ADTFLE...	23		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17343
P14618-23-unknown	ADTFLE...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137059
P14618-24-unknown	DTFLEH...	24		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18738
P14618-24-unknown	DTFLEH...	24		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17345
P14618-24-unknown	DTFLEH...	24		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137111
P14618-34-unknown	DIDSPP...	34		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P14618-34-unknown	DIDSPP...	34		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195730
P14618-77-unknown	SHGTHE...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18740
P14618-77-unknown	SHGTHE...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17347
P14618-77-unknown	SHGTHE...	77		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141096
P14618-77-	SHGTHE...	77			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P14618-77-	SHGTHE...	77			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14618-78-unknown	HGTHEY...	78		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5601
P14618-78-unknown	HGTHEY...	78		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141208
P14618-78-unknown	HGTHEY...	78		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14618-78-unknown	HGTHEY...	78		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P14618-79-unknown	GTHEYH...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18742
P14618-79-unknown	GTHEYH...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7328
P14618-79-unknown	GTHEYH...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17349
P14618-79-unknown	GTHEYH...	79		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141233
P14618-82-unknown	EYHAET...	82		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18744
P14618-82-unknown	EYHAET...	82		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17351
P14618-82-unknown	EYHAET...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141409
P14618-93-unknown	TATESF...	93		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177762
P14618-93-unknown	TATESF...	93		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177763
P14618-93-	TATESF...	93			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14618-97-	SFASDP...	97			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-97-unknown	SFASDP...	97		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170543
P14618-97-unknown	SFASDP...	97		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170544
P14618-100-unknown	SDPILY...	100		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18746
P14618-100-unknown	SDPILY...	100		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17353
P14618-100-unknown	SDPILY...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141557
P14618-100-unknown	SDPILY...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142396
P14618-109-	AVALDT...	109			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-109-unknown	AVALDT...	109		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173104
P14618-109-unknown	AVALDT...	109		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173105
P14618-110-unknown	VALDTK...	110		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172615
P14618-110-unknown	VALDTK...	110		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172616
P14618-110-	VALDTK...	110			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-110-	VALDTK...	110			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P14618-110-	VALDTK...	110			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14618-111-unknown	ALDTKG...	111		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173110
P14618-111-unknown	ALDTKG...	111		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173111
P14618-111-	ALDTKG...	111			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-126-	GSGTAE...	126			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-126-unknown	GSGTAE...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173107
P14618-126-unknown	GSGTAE...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173108
P14618-142-unknown	ITLDNA...	142		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P14618-142-unknown	ITLDNA...	142		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197556
P14618-142-unknown	ITLDNA...	142		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197557
P14618-185-unknown	VKQKGA...	185		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P14618-185-unknown	VKQKGA...	185		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197927
P14618-185-unknown	VKQKGA...	185		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197928
P14618-196-unknown	EVENGG...	196		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7330
P14618-196-unknown	EVENGG...	196		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5603
P14618-196-unknown	EVENGG...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145938
P14618-196-unknown	EVENGG...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146474
P14618-208-unknown	GVNLPG...	208		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167834
P14618-208-unknown	GVNLPG...	208		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167835
P14618-208-	GVNLPG...	208			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P14618-208-	GVNLPG...	208			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-208-	GVNLPG...	208			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14618-208-	GVNLPG...	208			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P14618-208-	GVNLPG...	208			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P14618-208-	GVNLPG...	208			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14618-211-unknown	LPGAAV...	211		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3648
P14618-211-unknown	LPGAAV...	211		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7333
P14618-211-unknown	LPGAAV...	211		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5606
P14618-211-unknown	LPGAAV...	211		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146459
P14618-211-unknown	LPGAAV...	211		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146988
P14618-213-	GAAVDL...	213			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-213-unknown	GAAVDL...	213		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170540
P14618-213-unknown	GAAVDL...	213		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170541
P14618-214-	AAVDLP...	214			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-214-unknown	AAVDLP...	214		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5609
P14618-214-unknown	AAVDLP...	214		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146556
P14618-214-unknown	AAVDLP...	214		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147152
P14618-215-	AVDLPA...	215			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-215-	AVDLPA...	215			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P14618-215-unknown	AVDLPA...	215		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173100
P14618-215-unknown	AVDLPA...	215		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173101
P14618-220-	AVSEKD...	220			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-220-unknown	AVSEKD...	220		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170546
P14618-220-unknown	AVSEKD...	220		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170547
P14618-237-unknown	VDMVFA...	237		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11217
P14618-237-unknown	VDMVFA...	237		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147452
P14618-237-unknown	VDMVFA...	237		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147979
P14618-360-	MLSGET...	360			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14618-360-unknown	MLSGET...	360		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173097
P14618-360-unknown	MLSGET...	360		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173098
P14618-362-unknown	SGETAK...	362		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13974
P14618-362-unknown	SGETAK...	362		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150892
P14618-362-unknown	SGETAK...	362		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151242
P14618-407-unknown	DPTEAT...	407		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18749
P14618-407-unknown	DPTEAT...	407		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17356
P14618-407-unknown	DPTEAT...	407		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151868
P14618-480-unknown	EAWAED...	480		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7336
P14618-480-unknown	EAWAED...	480		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152981
P14618-480-unknown	EAWAED...	480		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153186

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MSKPHS	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18732
...MSKPHS	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17337
...SKPHSE	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18733
...SKPHSE	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17338
...TQQLHA	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17339
...QQLHAA	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18734
...QQLHAA	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17341
...LHAAMA	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18736
...LHAAMA	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17343
...LHAAMA	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119913
...HAAMAD	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18738
...HAAMAD	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17345
...HAAMAD	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119994
...ARLNFS	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18740
...ARLNFS	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17347
...ARLNFS	76	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124249
...RLNFSH	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5601
...RLNFSH	77	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124369
...LNFSHG	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18742
...LNFSHG	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7328
...LNFSHG	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17349
...LNFSHG	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124394
...SHGTHE	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18744
...SHGTHE	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17351
...SHGTHE	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124580
...TESFAS	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18746
...TESFAS	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17353
...TESFAS	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125588
...DFLVTE	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7330
...DFLVTE	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5603
...DFLVTE	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129235
...DFLVTE	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129782
...KKGVNL	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3648
...KKGVNL	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7333
...KKGVNL	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5606
...KKGVNL	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129765
...KKGVNL	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130321
...VNLPGA	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5609
...VNLPGA	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129862
...VNLPGA	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130487
...GVEQDV	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11217
...GVEQDV	236	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130802
...GVEQDV	236	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131341
...DCIMLS	361	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13974
...DCIMLS	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134294
...DCIMLS	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134644
...APITSD	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18749
...APITSD	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17356
...APITSD	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135273
...KDPVQE	479	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7336
...KDPVQE	479	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136407
...KDPVQE	479	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136612
...VVPVP	531	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VVPVP	531	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74841
...VVPVP	531	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74840

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	5	KPHS.\|.SEAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	5	KPHS.\|.SEAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	6	PHSE.\|.EAGT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	6	PHSE.\|.EAGT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	19	QLHA.\|.AAMA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	20	LHAA.\|.AMAD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	20	LHAA.\|.AMAD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	22	AAMA.\|.ADTF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	22	AAMA.\|.ADTF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	23	AMAD.\|.DTFL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	23	AMAD.\|.DTFL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	76	LNFS.\|.SHGT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	76	LNFS.\|.SHGT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	77	NFSH.\|.HGTH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	78	FSHG.\|.GTHE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	78	FSHG.\|.GTHE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	78	FSHG.\|.GTHE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	81	GTHE.\|.EYHA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	81	GTHE.\|.EYHA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	99	SFAS.\|.SDPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	99	SFAS.\|.SDPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	195	LVTE.\|.EVEN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	195	LVTE.\|.EVEN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	210	GVNL.\|.LPGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	210	GVNL.\|.LPGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	210	GVNL.\|.LPGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	213	LPGA.\|.AAVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	236	EQDV.\|.VDMV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	361	IMLS.\|.SGET	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	406	ITSD.\|.DPTE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	406	ITSD.\|.DPTE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	479	PVQE.\|.EAWA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)