P50897: Palmitoyl-protein thioesterase 1

General Information

Protein names	- Palmitoyl-protein thioesterase 1 - PPT-1 - 3.1.2.22 - Palmitoyl-protein hydrolase 1
Gene names	PPT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P50897

3 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASPGCLWLL AVALLPWTCA SRALQHLDPP APLPLVIWHG MGDSCCNPLS MGAIKKMVEK
        70         80         90        100        110        120
KIPGIYVLSL EIGKTLMEDV ENSFFLNVNS QVTTVCQALA KDPKLQQGYN AMGFSQGGQF
       130        140        150        160        170        180
LRAVAQRCPS PPMINLISVG GQHQGVFGLP RCPGESSHIC DFIRKTLNAG AYSKVVQERL
       190        200        210        220        230        240
VQAEYWHDPI KEDVYRNHSI FLADINQERG INESYKKNLM ALKKFVMVKF LNDSIVDPVD
       250        260        270        280        290        300
SEWFGFYRSG QAKETIPLQE TSLYTQDRLG LKEMDNAGQL VFLATEGDHL QLSEEWFYAH

IIPFLG

Isoforms

- Isoform 2 of Palmitoyl-protein thioesterase 1

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P50897-1-unknown	MASPGC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86039
P50897-28-unknown	DPPAPL...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P50897-28-unknown	DPPAPL...	28	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P50897-188-unknown	DPIKED...	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17688
P50897-188-unknown	DPIKED...	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19169
P50897-188-unknown	DPIKED...	188	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141547

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AEYWHD	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17688
...AEYWHD	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19169
...AEYWHD	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124724
...IPFLG	306	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IPFLG	306	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81657

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	187	YWHD.\|.DPIK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	187	YWHD.\|.DPIK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)