Q01581: Hydroxymethylglutaryl-CoA synthase, cytoplasmic {ECO:0000305}

General Information

Protein names	- Hydroxymethylglutaryl-CoA synthase, cytoplasmic {ECO:0000305} - HMG-CoA synthase {ECO:0000303\|PubMed:20346956} - 2.3.3.10 - 3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene names	HMGCS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01581

4 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGSLPLNAE ACWPKDVGIV ALEIYFPSQY VDQAELEKYD GVDAGKYTIG LGQAKMGFCT
        70         80         90        100        110        120
DREDINSLCM TVVQNLMERN NLSYDCIGRL EVGTETIIDK SKSVKTNLMQ LFEESGNTDI
       130        140        150        160        170        180
EGIDTTNACY GGTAAVFNAV NWIESSSWDG RYALVVAGDI AVYATGNARP TGGVGAVALL
       190        200        210        220        230        240
IGPNAPLIFE RGLRGTHMQH AYDFYKPDML SEYPIVDGKL SIQCYLSALD RCYSVYCKKI
       250        260        270        280        290        300
HAQWQKEGND KDFTLNDFGF MIFHSPYCKL VQKSLARMLL NDFLNDQNRD KNSIYSGLEA
       310        320        330        340        350        360
FGDVKLEDTY FDRDVEKAFM KASSELFSQK TKASLLVSNQ NGNMYTSSVY GSLASVLAQY
       370        380        390        400        410        420
SPQQLAGKRI GVFSYGSGLA ATLYSLKVTQ DATPGSALDK ITASLCDLKS RLDSRTGVAP
       430        440        450        460        470        480
DVFAENMKLR EDTHHLVNYI PQGSIDSLFE GTWYLVRVDE KHRRTYARRP TPNDDTLDEG
       490        500        510        520
VGLVHSNIAT EHIPSPAKKV PRLPATAAEP EAAVISNGEH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01581-1-unknown	MPGSLP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01581-44-	AGKYTI...	44		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q01581-422-unknown	VFAENM...	422	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11874
Q01581-486-unknown	SNIATE...	486	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19314

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EVGTET	95	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000427339
...GVAPDV	421	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11874
...VGLVHS	485	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19314
...SNGEH	520	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SNGEH	520		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SNGEH	520		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SNGEH	520		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SNGEH	520		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	421	APDV.\|.VFAE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	485	LVHS.\|.SNIA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)