Q8NBP7: Proprotein convertase subtilisin/kexin type 9

General Information

Protein names	- Proprotein convertase subtilisin/kexin type 9 - 3.4.21.- - Neural apoptosis-regulated convertase 1 - NARC-1 - Proprotein convertase 9 - PC9 - Subtilisin/kexin-like protease PC9
Gene names	PCSK9
Organism	Homo sapiens
Protease Family	S08.039
Protease ID	S08.039
Chromosome location
UniProt ID	Q8NBP7

9 N-termini

9 C-termini

9 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MGTVSSRRSW WPLPLLLLLL LLLGPAGARA QEDEDGDYEE LVLALRSEED GLAEAPEHGT
        70         80         90        100        110        120
TATFHRCAKD PWRLPGTYVV VLKEETHLSQ SERTARRLQA QAARRGYLTK ILHVFHGLLP
       130        140        150        160        170        180
GFLVKMSGDL LELALKLPHV DYIEEDSSVF AQSIPWNLER ITPPRYRADE YQPPDGGSLV
       190        200        210        220        230        240
EVYLLDTSIQ SDHREIEGRV MVTDFENVPE EDGTRFHRQA SKCDSHGTHL AGVVSGRDAG
       250        260        270        280        290        300
VAKGASMRSL RVLNCQGKGT VSGTLIGLEF IRKSQLVQPV GPLVVLLPLA GGYSRVLNAA
       310        320        330        340        350        360
CQRLARAGVV LVTAAGNFRD DACLYSPASA PEVITVGATN AQDQPVTLGT LGTNFGRCVD
       370        380        390        400        410        420
LFAPGEDIIG ASSDCSTCFV SQSGTSQAAA HVAGIAAMML SAEPELTLAE LRQRLIHFSA
       430        440        450        460        470        480
KDVINEAWFP EDQRVLTPNL VAALPPSTHG AGWQLFCRTV WSAHSGPTRM ATAVARCAPD
       490        500        510        520        530        540
EELLSCSSFS RSGKRRGERM EAQGGKLVCR AHNAFGGEGV YAIARCCLLP QANCSVHTAP
       550        560        570        580        590        600
PAEASMGTRV HCHQQGHVLT GCSSHWEVED LGTHKPPVLR PRGQPNQCVG HREASIHASC
       610        620        630        640        650        660
CHAPGLECKV KEHGIPAPQE QVTVACEEGW TLTGCSALPG TSHVLGAYAV DNTCVVRSRD
       670        680        690
VSTTGSTSEG AVTAVAICCR SRHLAQASQE LQ

Isoforms

- Isoform 2 of Proprotein convertase subtilisin/kexin type 9

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 9 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
Q8NBP7-49-unknown	EDGLAE...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19694
Q8NBP7-50-unknown	DGLAEA...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19695
Q8NBP7-54-unknown	EAPEHG...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19696
Q8NBP7-83-unknown	KEETHL...	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27382
Q8NBP7-153-unknown	SIPWNL...	153	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8NBP7-153-unknown	SIPWNL...	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27383
Q8NBP7-153-unknown	SIPWNL...	153		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
Q8NBP7-219-unknown	QASKCD...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9812
Q8NBP7-219-unknown	QASKCD...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27068
Q8NBP7-219-unknown	QASKCD...	219	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139168
Q8NBP7-419-unknown	SAKDVI...	419	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19697
Q8NBP7-444-unknown	LPPSTH...	444	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18036
Q8NBP7-583-unknown	GQPNQC...	583		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALRSEE	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19694
...LRSEED	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19695
...EDGLAE	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19696
...YVVVLK	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27382
...SVFAQS	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27383
...TRFHRQ	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9812
...TRFHRQ	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27068
...TRFHRQ	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122242
...RLIHFS	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19697
...NLVAAL	443	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18036
...SQELQ	692	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	48	RSEE.\|.EDGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	49	SEED.\|.DGLA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	53	GLAE.\|.EAPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
PCSK9_HUMAN	82	VVLK.\|.KEET	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:The secretory proprotein conver... (S08.039)	12552133,
PCSK9_HUMAN	152	FAQS.\|.SIPW	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:NARC-1/PCSK9 and its natural mu... (S08.039)	15358785,
FURIN_HUMAN	218	FHRQ.\|.QASK	inferred from experiment	unknown	MEROPS	Seidah NG	Mayer G et al.:The regulated cell surface zymo... (S08.071)	18039650,
PCSK5_HUMAN	218	FHRQ.\|.QASK	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:The proprotein convertase (PC) ... (S08.076)	16912035,
MEP1B_HUMAN	418	IHFS.\|.SAKD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	443	VAAL.\|.LPPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK9_HUMAN	82	VVLK.\|.KEET	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:The secretory proprotein conver... (S08.039)	12552133,
PCSK9_HUMAN	152	FAQS.\|.SIPW	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:NARC-1/PCSK9 and its natural mu... (S08.039)	15358785,