P60660: Myosin light polypeptide 6

General Information

Protein names	- Myosin light polypeptide 6 - 17 kDa myosin light chain - LC17 - Myosin light chain 3 - MLC-3 - Myosin light chain alkali 3 - Myosin light chain A3 - Smooth muscle and nonmuscle myosin light chain alkali 6
Gene names	MYL6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P60660

7 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEM
        70         80         90        100        110        120
NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG NGTVMGAEIR HVLVTLGEKM
       130        140        150
TEEEVEMLVA GHEDSNGCIN YEAFVRHILS G

Isoforms

- Isoform Smooth muscle of Myosin light polypeptide 6

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P60660-1-unknown	MCDFTE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81973
P60660-2-unknown	MCDFTE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P60660-2-Acetylation	CDFTED...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P60660-2-Acetylation	CDFTED...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P60660-2-Acetylation	CDFTED...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P60660-2-Acetylation	CDFTED...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P60660-2-Acetylation	CDFTED...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110410
P60660-11-unknown	EFKEAF...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19230
P60660-11-unknown	EFKEAF...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194897
P60660-51-	VLGNPK...	51			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P60660-51-unknown	VLGNPK...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169480
P60660-68-unknown	EHFLPM...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19231
P60660-68-unknown	EHFLPM...	68		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140484

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDQTAE	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19230
...KVLDFE	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19231
...KVLDFE	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123611
...HILSG	151	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	10	QTAE.\|.EFKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	67	LDFE.\|.EHFL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)