P52597: Heterogeneous nuclear ribonucleoprotein F

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein F - hnRNP F - Nucleolin-like protein mcs94-1 - Heterogeneous nuclear ribonucleoprotein F, N-terminally processed
Gene names	HNRNPF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52597

21 N-termini

7 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMLGPEGGEG FVVKLRGLPW SCSVEDVQNF LSDCTIHDGA AGVHFIYTRE GRQSGEAFVE
        70         80         90        100        110        120
LGSEDDVKMA LKKDRESMGH RYIEVFKSHR TEMDWVLKHS GPNSADSAND GFVRLRGLPF
       130        140        150        160        170        180
GCTKEEIVQF FSGLEIVPNG ITLPVDPEGK ITGEAFVQFA SQELAEKALG KHKERIGHRY
       190        200        210        220        230        240
IEVFKSSQEE VRSYSDPPLK FMSVQRPGPY DRPGTARRYI GIVKQAGLER MRPGAYSTGY
       250        260        270        280        290        300
GGYEEYSGLS DGYGFTTDLF GRDLSYCLSG MYDHRYGDSE FTVQSTTGHC VHMRGLPYKA
       310        320        330        340        350        360
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHEE AVAAMSKDRA NMQHRYIELF
       370        380        390        400        410
LNSTTGASNG AYSSQVMQGM GVSAAQATYS GLESQSVSGC YGAGYSGQNS MGGYD

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

21 N-termini - 7 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52597-1-Acetylation	MMLGPE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52597-1-Acetylation	MMLGPE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P52597-1-Acetylation	MMLGPE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P52597-1-	MMLGPE...	1			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52597-2-	MLGPEG...	2			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P52597-2-Acetylation	MLGPEG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52597-2-Acetylation	MLGPEG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P52597-2-Acetylation	MLGPEG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P52597-2-Acetylation	MLGPEG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P52597-2-Acetylation	MLGPEG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P52597-2-unknown	MLGPEG...	2			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52597-2-unknown	MLGPEG...	2			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52597-4-unknown	GPEGGE...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7548
P52597-32-unknown	SDCTIH...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6002
P52597-39-	GAAGVH...	39			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52597-104-	SADSAN...	104			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52597-104-	SADSAN...	104			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52597-104-	SADSAN...	104			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52597-104-	SADSAN...	104			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52597-104-	SADSAN...	104			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52597-107-	SANDGF...	107			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52597-140-	GITLPV...	140			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52597-140-	GITLPV...	140			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52597-140-	GITLPV...	140			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52597-155-unknown	AFVQFA...	155		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11657
P52597-193-	SYSDPP...	193			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52597-193-	SYSDPP...	193			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52597-206-unknown	RPGPYD...	206		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6003
P52597-206-unknown	RPGPYD...	206		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7549
P52597-219-	YIGIVK...	219			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P52597-252-unknown	GYGFTT...	252		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1235
P52597-252-	GYGFTT...	252			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P52597-252-	GYGFTT...	252			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52597-252-	GYGFTT...	252			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52597-252-	GYGFTT...	252			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52597-254-unknown	GFTTDL...	254			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52597-255-unknown	FTTDLF...	255		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3845
P52597-285-unknown	STTGHC...	285		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19188
P52597-308-	FFSPLN...	308			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VQNFLS	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6002
...KITGEA	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11657
...FMSVQR	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6003
...FMSVQR	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7549
...SGLSDG	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1235
...SDGYGF	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3845
...EFTVQS	284	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19188
...MGGYD	415	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	3	MMLG.\|.GPEG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	31	NFLS.\|.SDCT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	154	TGEA.\|.AFVQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	205	SVQR.\|.RPGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	205	SVQR.\|.RPGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP1_HUMAN	251	LSDG.\|.GYGF	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CATB_HUMAN	254	GYGF.\|.FTTD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	284	TVQS.\|.STTG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)