P40925: Malate dehydrogenase, cytoplasmic
Protein names | - Malate dehydrogenase, cytoplasmic - 1.1.1.37 - Cytosolic malate dehydrogenase - Diiodophenylpyruvate reductase - 1.1.1.96 |
---|---|
Gene names | MDH1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P40925 |
15
N-termini
10
C-termini
9
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSEPIRVLVT GAAGQIAYSL LYSIGNGSVF GKDQPIILVL LDITPMMGVL DGVLMELQDC
70 80 90 100 110 120
ALPLLKDVIA TDKEDVAFKD LDVAILVGSM PRREGMERKD LLKANVKIFK SQGAALDKYA
130 140 150 160 170 180
KKSVKVIVVG NPANTNCLTA SKSAPSIPKE NFSCLTRLDH NRAKAQIALK LGVTANDVKN
190 200 210 220 230 240
VIIWGNHSST QYPDVNHAKV KLQGKEVGVY EALKDDSWLK GEFVTTVQQR GAAVIKARKL
250 260 270 280 290 300
SSAMSAAKAI CDHVRDIWFG TPEGEFVSMG VISDGNSYGV PDDLLYSFPV VIKNKTWKFV
310 320 330
EGLPINDFSR EKMDLTAKEL TEEKESAFEF LSSA
Isoforms
- Isoform 2 of Malate dehydrogenase, cytoplasmic - Isoform 3 of Malate dehydrogenase, cytoplasmicSequence View
10 20 30 40 50 60
MSEPIRVLVT GAAGQIAYSL LYSIGNGSVF GKDQPIILVL LDITPMMGVL DGVLMELQDC
70 80 90 100 110 120
ALPLLKDVIA TDKEDVAFKD LDVAILVGSM PRREGMERKD LLKANVKIFK SQGAALDKYA
130 140 150 160 170 180
KKSVKVIVVG NPANTNCLTA SKSAPSIPKE NFSCLTRLDH NRAKAQIALK LGVTANDVKN
190 200 210 220 230 240
VIIWGNHSST QYPDVNHAKV KLQGKEVGVY EALKDDSWLK GEFVTTVQQR GAAVIKARKL
250 260 270 280 290 300
SSAMSAAKAI CDHVRDIWFG TPEGEFVSMG VISDGNSYGV PDDLLYSFPV VIKNKTWKFV
310 320 330
EGLPINDFSR EKMDLTAKEL TEEKESAFEF LSSA
10 20 30 40 50 60
MSEPIRVLVT GAAGQIAYSL LYSIGNGSVF GKDQPIILVL LDITPMMGVL DGVLMELQDC
70 80 90 100 110 120
ALPLLKDVIA TDKEDVAFKD LDVAILVGSM PRREGMERKD LLKANVKIFK SQGAALDKYA
130 140 150 160 170 180
KKSVKVIVVG NPANTNCLTA SKSAPSIPKE NFSCLTRLDH NRAKAQIALK LGVTANDVKN
190 200 210 220 230 240
VIIWGNHSST QYPDVNHAKV KLQGKEVGVY EALKDDSWLK GEFVTTVQQR GAAVIKARKL
250 260 270 280 290 300
SSAMSAAKAI CDHVRDIWFG TPEGEFVSMG VISDGNSYGV PDDLLYSFPV VIKNKTWKFV
310 320 330
EGLPINDFSR EKMDLTAKEL TEEKESAFEF LSSA
Protein Neighborhood
Domains & Features
15 N-termini - 10 C-termini - 9 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P40925-2-unknown | MSEPIR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P40925-2-unknown | MSEPIR... | 1 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P40925-2-Acetylation | SEPIRV... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P40925-2-Acetylation | SEPIRV... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110286 | ||
P40925-70-unknown | ATDKED... | 70 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7459 | |||
P40925-70-unknown | ATDKED... | 70 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141699 | |||
P40925-82-unknown | DVAILV... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19096 | |||
P40925-82-unknown | DVAILV... | 82 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142409 | |||
P40925-90-unknown | MPRREG... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt80715 | |||
P40925-90-unknown | MPRREG... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt100154 | |||
P40925-140-unknown | ASKSAP... | 140 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5854 | |||
P40925-140-unknown | ASKSAP... | 140 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139291 | |||
P40925-140-unknown | ASKSAP... | 140 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145082 | |||
P40925-185-unknown | GNHSST... | 185 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7461 | |||
P40925-185-unknown | GNHSST... | 185 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142159 | |||
P40925-185-unknown | GNHSST... | 185 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146642 | |||
P40925-186-unknown | NHSSTQ... | 186 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3793 | |||
P40925-186-unknown | NHSSTQ... | 186 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5857 | |||
P40925-186-unknown | NHSSTQ... | 186 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142258 | |||
P40925-186-unknown | NHSSTQ... | 186 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146683 | |||
P40925-187- | HSSTQY... | 187 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P40925-187-unknown | HSSTQY... | 187 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172822 | |||
P40925-187-unknown | HSSTQY... | 187 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172821 | |||
P40925-188-unknown | SSTQYP... | 188 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5860 | |||
P40925-188-unknown | SSTQYP... | 188 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142379 | |||
P40925-188-unknown | SSTQYP... | 188 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146774 | |||
P40925-188-unknown | SSTQYP... | 188 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P40925-188-unknown | SSTQYP... | 188 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P40925-189-unknown | STQYPD... | 189 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5863 | |||
P40925-189-unknown | STQYPD... | 189 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142427 | |||
P40925-189-unknown | STQYPD... | 189 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146813 | |||
P40925-191-unknown | QYPDVN... | 191 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5866 | |||
P40925-191-unknown | QYPDVN... | 191 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142513 | |||
P40925-191-unknown | QYPDVN... | 191 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146930 | |||
P40925-277-unknown | SYGVPD... | 277 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171849 | |||
P40925-277-unknown | SYGVPD... | 277 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171848 | |||
P40925-277- | SYGVPD... | 277 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LKDVIA | 69 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7459 | |||
...LKDVIA | 69 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124881 | |||
...AFKDLD | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19096 | |||
...AFKDLD | 81 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125602 | |||
...TNCLTA | 139 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5854 | |||
...TNCLTA | 139 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122366 | |||
...TNCLTA | 139 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128363 | |||
...NVIIWG | 184 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7461 | |||
...NVIIWG | 184 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125346 | |||
...NVIIWG | 184 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129951 | |||
...VIIWGN | 185 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3793 | |||
...VIIWGN | 185 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5857 | |||
...VIIWGN | 185 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125447 | |||
...VIIWGN | 185 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129993 | |||
...IWGNHS | 187 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5860 | |||
...IWGNHS | 187 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125571 | |||
...IWGNHS | 187 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130085 | |||
...WGNHSS | 188 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5863 | |||
...WGNHSS | 188 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125621 | |||
...WGNHSS | 188 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130136 | |||
...NHSSTQ | 190 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5866 | |||
...NHSSTQ | 190 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125708 | |||
...NHSSTQ | 190 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130261 | |||
...FLSSA | 334 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...FLSSA | 334 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt76333 | |||
...FLSSA | 334 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt76334 | |||
...FLSSA | 334 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...FLSSA | 334 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
...FLSSA | 334 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...FLSSA | 334 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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