Q15056: Eukaryotic translation initiation factor 4H
Protein names | - Eukaryotic translation initiation factor 4H - eIF-4H - Williams-Beuren syndrome chromosomal region 1 protein |
---|---|
Gene names | EIF4H |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q15056 |
22
N-termini
9
C-termini
8
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA
70 80 90 100 110 120
IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK
130 140 150 160 170 180
QDKGGFGFRK GGPDDRGMGS SRESRGGWDS RDDFNSGFRD DFLGGRGGSR PGDRRTGPPM
190 200 210 220 230 240
GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE
EVVQKEQE
Isoforms
- Isoform Short of Eukaryotic translation initiation factor 4HSequence View
10 20 30 40 50 60
MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA
70 80 90 100 110 120
IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK
130 140 150 160 170 180
QDKGGFGFRK GGPDDRGMGS SRESRGGWDS RDDFNSGFRD DFLGGRGGSR PGDRRTGPPM
190 200 210 220 230 240
GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE
EVVQKEQE
Protein Neighborhood
Domains & Features
22 N-termini - 9 C-termini - 8 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q15056-1-unknown | MADFDT... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt77567 | |||
Q15056-2-unknown | MADFDT... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q15056-2-Acetylation | ADFDTY... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q15056-2-Acetylation | ADFDTY... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q15056-2-Acetylation | ADFDTY... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
Q15056-2-Acetylation | ADFDTY... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q15056-2-Acetylation | ADFDTY... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111484 | ||
Q15056-53-unknown | TVQGDI... | 53 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6439 | |||
Q15056-53-unknown | TVQGDI... | 53 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139371 | |||
Q15056-54-unknown | VQGDID... | 54 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4065 | |||
Q15056-54-unknown | VQGDID... | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139485 | |||
Q15056-57-unknown | DIDAIF... | 57 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17955 | |||
Q15056-57-unknown | DIDAIF... | 57 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19547 | |||
Q15056-57-unknown | DIDAIF... | 57 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139655 | |||
Q15056-86-unknown | YVEFDE... | 86 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6441 | |||
Q15056-86-unknown | YVEFDE... | 86 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141622 | |||
Q15056-94-unknown | SLKEAL... | 94 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2210 | |||
Q15056-94-unknown | SLKEAL... | 94 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142086 | |||
Q15056-94- | SLKEAL... | 94 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q15056-94- | SLKEAL... | 94 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q15056-94- | SLKEAL... | 94 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q15056-94- | SLKEAL... | 94 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q15056-98-unknown | ALTYDG... | 98 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175938 | |||
Q15056-98- | ALTYDG... | 98 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q15056-100- | TYDGAL... | 100 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q15056-100-unknown | TYDGAL... | 100 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14523 | |||
Q15056-100-unknown | TYDGAL... | 100 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q15056-100-unknown | TYDGAL... | 100 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142414 | |||
Q15056-121- | QDKGGF... | 121 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q15056-121- | QDKGGF... | 121 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q15056-195- | MDFREP... | 195 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q15056-195-unknown | MDFREP... | 195 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170963 | |||
Q15056-224- | QVANPN... | 224 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q15056-224-unknown | QVANPN... | 224 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166788 | |||
Q15056-225- | VANPNS... | 225 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q15056-225- | VANPNS... | 225 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q15056-225-unknown | VANPNS... | 225 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166785 | |||
Q15056-230-unknown | SAIFGG... | 230 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14525 | |||
Q15056-230-unknown | SAIFGG... | 230 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146961 | |||
Q15056-230- | SAIFGG... | 230 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...NLPFNT | 52 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6439 | |||
...NLPFNT | 52 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122451 | |||
...LPFNTV | 53 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4065 | |||
...LPFNTV | 53 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122575 | |||
...NTVQGD | 56 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17955 | |||
...NTVQGD | 56 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19547 | |||
...NTVQGD | 56 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122750 | |||
...FKGFCY | 85 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6441 | |||
...FKGFCY | 85 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124801 | |||
...FDEVDS | 93 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2210 | |||
...FDEVDS | 93 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125271 | |||
...LKEALT | 99 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14523 | |||
...LKEALT | 99 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125607 | |||
...VANPNS | 229 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14525 | |||
...VANPNS | 229 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130293 | |||
...QKEQE | 248 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...QKEQE | 248 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
...QKEQE | 248 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...QKEQE | 248 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73185 | |||
...QKEQE | 248 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...QKEQE | 248 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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