Q9NQG5: Regulation of nuclear pre-mRNA domain-containing protein 1B

General Information

Protein names	- Regulation of nuclear pre-mRNA domain-containing protein 1B - Cell cycle-related and expression-elevated protein in tumor
Gene names	RPRD1B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NQG5

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSFSESALE KKLSELSNSQ QSVQTLSLWL IHHRKHAGPI VSVWHRELRK AKSNRKLTFL
        70         80         90        100        110        120
YLANDVIQNS KRKGPEFTRE FESVLVDAFS HVAREADEGC KKPLERLLNI WQERSVYGGE
       130        140        150        160        170        180
FIQQLKLSME DSKSPPPKAT EEKKSLKRTF QQIQEEEDDD YPGSYSPQDP SAGPLLTEEL
       190        200        210        220        230        240
IKALQDLENA ASGDATVRQK IASLPQEVQD VSLLEKITDK EAAERLSKTV DEACLLLAEY
       250        260        270        280        290        300
NGRLAAELED RRQLARMLVE YTQNQKDVLS EKEKKLEEYK QKLARVTQVR KELKSHIQSL
       310        320
PDLSLLPNVT GGLAPLPSAG DLFSTD

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NQG5-2-unknown	MSSFSE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQG5-2-Acetylation	SSFSES...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQG5-2-Acetylation	SSFSES...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9NQG5-126-unknown	KLSMED...	126		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13383
Q9NQG5-163-	GSYSPQ...	163			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9NQG5-210-unknown	DVSLLE...	210		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19814
Q9NQG5-210-unknown	DVSLLE...	210		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18138

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FIQQLK	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13383
...PQEVQD	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19814
...PQEVQD	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18138
...GGLAPL	315	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416420
...LFSTD	326	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	125	QQLK.\|.KLSM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	209	EVQD.\|.DVSL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	209	EVQD.\|.DVSL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)