Q96IZ0: PRKC apoptosis WT1 regulator protein

General Information

Protein names	- PRKC apoptosis WT1 regulator protein - Prostate apoptosis response 4 protein - Par-4
Gene names	PAWR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96IZ0

5 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATGGYRTSS GLGGSTTDFL EEWKAKREKM RAKQNPPGPA PPGGGSSDAA GKPPAGALGT
        70         80         90        100        110        120
PAAAAANELN NNLPGGAPAA PAVPGPGGVN CAVGSAMLTR AAPGPRRSED EPPAASASAA
       130        140        150        160        170        180
PPPQRDEEEP DGVPEKGKSS GPSARKGKGQ IEKRKLREKR RSTGVVNIPA AECLDEYEDD
       190        200        210        220        230        240
EAGQKERKRE DAITQQNTIQ NEAVNLLDPG SSYLLQEPPR TVSGRYKSTT SVSEEDVSSR
       250        260        270        280        290        300
YSRTDRSGFP RYNRDANVSG TLVSSSTLEK KIEDLEKEVV RERQENLRLV RLMQDKEEMI
       310        320        330        340
GKLKEEIDLL NRDLDDIEDE NEQLKQENKT LLKVVGQLTR

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96IZ0-1-unknown	MATGGY...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96IZ0-10-unknown	SGLGGS...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19739
Q96IZ0-10-unknown	SGLGGS...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18078
Q96IZ0-132-unknown	GVPEKG...	132	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2294
Q96IZ0-132-	GVPEKG...	132		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96IZ0-132-	GVPEKG...	132		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96IZ0-270-unknown	KKIEDL...	270	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447507

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GYRTSS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19739
...GYRTSS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18078
...GTPAAA	63	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449928
...NNLPGG	75	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447454
...EEEPDG	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2294
...GQLTR	340	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	9	RTSS.\|.SGLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	9	RTSS.\|.SGLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	131	EPDG.\|.GVPE	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> PAWR_HUMAN @131

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)