P00505: Aspartate aminotransferase, mitochondrial

General Information

Protein names	- Aspartate aminotransferase, mitochondrial - mAspAT - 2.6.1.1 {ECO:0000269\|PubMed:26902786} - 2.6.1.7 - Fatty acid-binding protein - FABP-1 - Glutamate oxaloacetate transaminase 2 - Kynurenine aminotransferase 4 - Kynurenine aminotransferase IV - Kynurenine--oxoglutarate transaminase 4 - Kynurenine--oxoglutarate transaminase IV - Plasma membrane-associated fatty acid-binding protein - FABPpm - Transaminase A
Gene names	GOT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00505

14 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA FKRDTNSKKM
        70         80         90        100        110        120
NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG GLAEFCKASA ELALGENSEV
       130        140        150        160        170        180
LKSGRFVTVQ TISGTGALRI GASFLQRFFK FSRDVFLPKP TWGNHTPIFR DAGMQLQGYR
       190        200        210        220        230        240
YYDPKTCGFD FTGAVEDISK IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA
       250        260        270        280        290        300
FFDMAYQGFA SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE
       310        320        330        340        350        360
AKRVESQLKI LIRPMYSNPP LNGARIAAAI LNTPDLRKQW LQEVKVMADR IIGMRTQLVS
       370        380        390        400        410        420
NLKKEGSTHN WQHITDQIGM FCFTGLKPEQ VERLIKEFSI YMTKDGRISV AGVTSSNVGY
       430
LAHAIHQVTK

Isoforms

- Isoform 2 of Aspartate aminotransferase, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

14 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P00505-1-unknown	MALLHS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65906
P00505-16-unknown	AFHPGL...	16		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P00505-16-unknown	AFHPGL...	16		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P00505-16-unknown	AFHPGL...	16	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159391
P00505-16-	AFHPGL...	16		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P00505-16-	AFHPGL...	16		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P00505-16-	AFHPGL...	16		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P00505-16-	AFHPGL...	16		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P00505-30-	SSWWTH...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P00505-30-	SSWWTH...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P00505-30-	SSWWTH...	30		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P00505-30-	SSWWTH...	30		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P00505-30-	SSWWTH...	30		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P00505-30-unknown	SSWWTH...	30	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00505-30-unknown	SSWWTH...	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt114749
P00505-39-unknown	GPPDPI...	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16986
P00505-39-unknown	GPPDPI...	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18343
P00505-39-unknown	GPPDPI...	39	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138255
P00505-97-unknown	LPIGGL...	97	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18345
P00505-97-unknown	LPIGGL...	97	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00505-97-unknown	LPIGGL...	97	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P00505-112-unknown	LALGEN...	112	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3314
P00505-191-unknown	FTGAVE...	191	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7100
P00505-191-unknown	FTGAVE...	191	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3315
P00505-191-unknown	FTGAVE...	191	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144650
P00505-212-unknown	CAHNPT...	212	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3317
P00505-212-unknown	CAHNPT...	212	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145513
P00505-213-unknown	AHNPTG...	213	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173542
P00505-213-	AHNPTG...	213		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P00505-213-	AHNPTG...	213		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P00505-248-unknown	GFASGD...	248	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5313
P00505-248-unknown	GFASGD...	248	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146728
P00505-385-unknown	GLKPEQ...	385	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5315
P00505-385-unknown	GLKPEQ...	385	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150786

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...THVEMG	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16986
...THVEMG	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18343
...THVEMG	38	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121286
...LDKEYL	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18345
...KASAEL	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3314
...TCGFDF	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7100
...TCGFDF	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3315
...TCGFDF	190	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127917
...LLLHAC	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3317
...LLLHAC	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128810
...DMAYQG	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5313
...DMAYQG	247	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130039
...MFCFTG	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5315
...MFCFTG	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134188
...HQVTK	430	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HQVTK	430	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61524

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	38	VEMG.\|.GPPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	38	VEMG.\|.GPPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	96	KEYL.\|.LPIG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	111	SAEL.\|.LALG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	190	GFDF.\|.FTGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	190	GFDF.\|.FTGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	211	LHAC.\|.CAHN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	247	AYQG.\|.GFAS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	384	CFTG.\|.GLKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)