O43278: Kunitz-type protease inhibitor 1

General Information

Protein names	- Kunitz-type protease inhibitor 1 - Hepatocyte growth factor activator inhibitor type 1 - HAI-1
Gene names	SPINT1
Organism	Homo sapiens
Protease Family
Protease ID	I02.007
Chromosome location
UniProt ID	O43278

4 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPARTMARA RLAPAGIPAV ALWLLCTLGL QGTQAGPPPA PPGLPAGADC LNSFTAGVPG
        70         80         90        100        110        120
FVLDTNASVS NGATFLESPT VRRGWDCVRA CCTTQNCNLA LVELQPDRGE DAIAACFLIN
       130        140        150        160        170        180
CLYEQNFVCK FAPREGFINY LTREVYRSYR QLRTQGFGGS GIPKAWAGID LKVQPQEPLV
       190        200        210        220        230        240
LKDVENTDWR LLRGDTDVRV ERKDPNQVEL WGLKEGTYLF QLTVTSSDHP EDTANVTVTV
       250        260        270        280        290        300
LSTKQTEDYC LASNKVGRCR GSFPRWYYDP TEQICKSFVY GGCLGNKNNY LREEECILAC
       310        320        330        340        350        360
RGVQGGPLRG SSGAQATFPQ GPSMERRHPV CSGTCQPTQF RCSNGCCIDS FLECDDTPNC
       370        380        390        400        410        420
PDASDEAACE KYTSGFDELQ RIHFPSDKGH CVDLPDTGLC KESIPRWYYN PFSEHCARFT
       430        440        450        460        470        480
YGGCYGNKNN FEEEQQCLES CRGISKKDVF GLRREIPIPS TGSVEMAVAV FLVICIVVVV
       490        500        510        520
AILGYCFFKN QRKDFHGHHH HPPPTPASST VSTTEDTEHL VYNHTTRPL

Isoforms

- Isoform 2 of Kunitz-type protease inhibitor 1

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O43278-1-unknown	MAPART...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90472
O43278-36-unknown	GPPPAP...	36	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43278-36-unknown	GPPPAP...	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115293
O43278-328-unknown	HPVCSG...	328	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16876
O43278-328-unknown	HPVCSG...	328	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199000
O43278-384-unknown	FPSDKG...	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18227
O43278-384-unknown	FPSDKG...	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16877
O43278-384-unknown	FPSDKG...	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151366

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SMERRH	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16876
...LQRIHF	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18227
...LQRIHF	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16877
...LQRIHF	383	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134768
...TTRPL	529	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TTRPL	529	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86090

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	327	ERRH.\|.HPVC	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	383	RIHF.\|.FPSD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	383	RIHF.\|.FPSD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)