P04075: Fructose-bisphosphate aldolase A

General Information

Protein names	- Fructose-bisphosphate aldolase A - 4.1.2.13 - Lung cancer antigen NY-LU-1 - Muscle-type aldolase
Gene names	ALDOA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04075

24 N-termini

12 C-termini

24 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE NTEENRRFYR
        70         80         90        100        110        120
QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS KGGVVGIKVD KGVVPLAGTN
       130        140        150        160        170        180
GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKIGEHTPS ALAIMENANV LARYASICQQ
       190        200        210        220        230        240
NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC
       250        260        270        280        290        300
TQKFSHEEIA MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF
       310        320        330        340        350        360
SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG AAASESLFVS

NHAY

Isoforms

- Isoform 2 of Fructose-bisphosphate aldolase A

Sequence View

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Evidence Codes:

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Protein Neighborhood

Domains & Features

24 N-termini - 12 C-termini - 24 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04075-2-unmodified	PYQYPA...	2			other		CNRS/ISV	Large_scale_NTA_Human
P04075-2-unknown	PYQYPA...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04075-2-unknown	PYQYPA...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P04075-2-unknown	PYQYPA...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P04075-2-unknown	PYQYPA...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111599
P04075-5-unknown	YPALTP...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7181
P04075-5-unknown	YPALTP...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3363
P04075-5-unknown	YPALTP...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18420
P04075-5-unknown	YPALTP...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5368
P04075-5-unknown	YPALTP...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194653
P04075-19-acetylation	IAHRIV...	19	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04075-19-acetylation	IAHRIV...	19	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181412
P04075-23-acetylation	IVAPGK...	23	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04075-23-acetylation	IVAPGK...	23	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181414
P04075-32-unknown	AADEST...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7182
P04075-32-unknown	AADEST...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5369
P04075-32-unknown	AADEST...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141610
P04075-33-unknown	ADESTG...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7184
P04075-33-unknown	ADESTG...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5371
P04075-33-unknown	ADESTG...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141657
P04075-34-unknown	DESTGS...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17079
P04075-34-unknown	DESTGS...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18421
P04075-34-unknown	DESTGS...	34		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141734
P04075-44-unknown	LQSIGT...	44		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181416
P04075-44-	LQSIGT...	44			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04075-46-unknown	SIGTEN...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7186
P04075-46-unknown	SIGTEN...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3364
P04075-46-unknown	SIGTEN...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5373
P04075-46-unknown	SIGTEN...	46		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142385
P04075-47-unknown	IGTENT...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17081
P04075-47-unknown	IGTENT...	47		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142461
P04075-90-unknown	DGRPFP...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17083
P04075-90-unknown	DGRPFP...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18423
P04075-90-unknown	DGRPFP...	90		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144501
P04075-119-unknown	TNGETT...	119		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3366
P04075-119-unknown	TNGETT...	119		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145621
P04075-121-	GETTTQ...	121			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P04075-121-	GETTTQ...	121			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04075-121-	GETTTQ...	121			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P04075-121-	GETTTQ...	121			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P04075-121-	GETTTQ...	121			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P04075-121-unknown	GETTTQ...	121		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166821
P04075-176-	SICQQN...	176			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04075-176-unknown	SICQQN...	176		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170573
P04075-182-	GIVPIV...	182			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P04075-182-	GIVPIV...	182			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04075-182-	GIVPIV...	182			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P04075-182-	GIVPIV...	182			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P04075-182-	GIVPIV...	182			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P04075-182-unknown	GIVPIV...	182		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166819
P04075-230-unknown	KPNMVT...	230		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7188
P04075-230-unknown	KPNMVT...	230		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5375
P04075-230-unknown	KPNMVT...	230		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149439
P04075-234-unknown	VTPGHA...	234		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5377
P04075-234-unknown	VTPGHA...	234		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7190
P04075-234-unknown	VTPGHA...	234		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3368
P04075-234-unknown	VTPGHA...	234		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149542
P04075-272-unknown	SGGQSE...	272		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5379
P04075-272-unknown	SGGQSE...	272		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150440
P04075-279-unknown	EASINL...	279		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18425
P04075-279-unknown	EASINL...	279		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150592

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKGILA	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7182
...GKGILA	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5369
...GKGILA	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124788
...KGILAA	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7184
...KGILAA	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5371
...KGILAA	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124837
...GILAAD	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17079
...GILAAD	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18421
...GILAAD	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124916
...AKRLQS	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7186
...AKRLQS	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3364
...AKRLQS	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5373
...AKRLQS	45	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125577
...KRLQSI	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17081
...KRLQSI	46	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125655
...YQKADD	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17083
...YQKADD	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18423
...YQKADD	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127766
...VPLAGT	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3366
...VPLAGT	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128920
...EGTLLK	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7188
...EGTLLK	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5375
...EGTLLK	229	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132824
...LKPNMV	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5377
...LKPNMV	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7190
...LKPNMV	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3368
...LKPNMV	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132926
...GITFLS	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5379
...GITFLS	271	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133836
...GQSEEE	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18425
...GQSEEE	278	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133989
...SNHAY	364	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SNHAY	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62334

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	4	PYQY.\|.YPAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	4	PYQY.\|.YPAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	4	PYQY.\|.YPAL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	4	PYQY.\|.YPAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	31	GILA.\|.AADE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	31	GILA.\|.AADE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	32	ILAA.\|.ADES	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	32	ILAA.\|.ADES	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	33	LAAD.\|.DEST	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	33	LAAD.\|.DEST	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	45	RLQS.\|.SIGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	45	RLQS.\|.SIGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	45	RLQS.\|.SIGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	46	LQSI.\|.IGTE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	89	KADD.\|.DGRP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	89	KADD.\|.DGRP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	118	LAGT.\|.TNGE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	229	TLLK.\|.KPNM	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	229	TLLK.\|.KPNM	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	233	PNMV.\|.VTPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	233	PNMV.\|.VTPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	233	PNMV.\|.VTPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	271	TFLS.\|.SGGQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	278	SEEE.\|.EASI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)