Q04760: Lactoylglutathione lyase

General Information

Protein names	- Lactoylglutathione lyase - 4.4.1.5 - Aldoketomutase - Glyoxalase I - Glx I - Ketone-aldehyde mutase - Methylglyoxalase - S-D-lactoylglutathione methylglyoxal lyase
Gene names	GLO1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q04760

9 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK
        70         80         90        100        110        120
CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS
       130        140        150        160        170        180
DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM

ATLM

Isoforms

- Isoform 2 of Lactoylglutathione lyase

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q04760-1-unknown	MAEPQP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79549
Q04760-2-unknown	MAEPQP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q04760-2-unknown	MAEPQP...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q04760-2-Acetylation	AEPQPP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q04760-2-Acetylation	AEPQPP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q04760-2-Acetylation	AEPQPP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q04760-2-Acetylation	AEPQPP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q04760-2-Acetylation	AEPQPP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111647
Q04760-15-	AALSCC...	15			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q04760-15-acetylation	AALSCC...	15	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q04760-15-acetylation	AALSCC...	15	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183012
Q04760-15-unknown	AALSCC...	15		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183010
Q04760-19-unknown	CCSDAD...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7729
Q04760-19-unknown	CCSDAD...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136769
Q04760-24-unknown	DPSTKD...	24		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19349
Q04760-24-unknown	DPSTKD...	24		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17852
Q04760-24-unknown	DPSTKD...	24		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137141
Q04760-103-unknown	HNWGTE...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7731

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAALSC	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7729
...CCSDAD	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19349
...CCSDAD	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17852
...CCSDAD	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120033
...TLELTH	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7731
...TLELTH	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154403
...MATLM	184	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MATLM	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75167

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	18	ALSC.\|.CCSD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	23	SDAD.\|.DPST	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	23	SDAD.\|.DPST	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	102	ELTH.\|.HNWG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)