P30046: D-dopachrome decarboxylase

General Information

Protein names	- D-dopachrome decarboxylase - 4.1.1.84 - D-dopachrome tautomerase - Phenylpyruvate tautomerase II
Gene names	DDT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30046

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL
70 80 90 100 110
SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRILIRF FPLESWQIGK IGTVMTFL

Isoforms

- Isoform 2 of D-dopachrome decarboxylase

Sequence View

10 20 30 40 50 60
MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL
70 80 90 100 110
SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRILIRF FPLESWQIGK IGTVMTFL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P30046-2-unknown	MPFLEL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30046-2-unmodified	PFLELD...	2			other		CNRS/ISV	Large_scale_NTA_Human
P30046-2-Acetylation	PFLELD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30046-6-unknown	LDTNLP...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7410
P30046-7-unknown	DTNLPA...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19019
P30046-67-unknown	VVGTAE...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3759

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MPFLEL	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7410
...PFLELD	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19019
...ISSIGV	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3759
...VMTFL	118	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	5	FLEL.\|.LDTN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	6	LELD.\|.DTNL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	66	SIGV.\|.VVGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)