O43143: Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15

General Information

Protein names	- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 - 3.6.4.13 {ECO:0000269\|PubMed:19432882} - ATP-dependent RNA helicase #46 - DEAH box protein 15
Gene names	DHX15
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43143

4 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSKRHRLDLG EDYPSGKKRA GTDGKDRDRD RDREDRSKDR DRERDRGDRE REREKEKEKE
        70         80         90        100        110        120
LRASTNAMLI SAGLPPLKAS HSAHSTHSAH STHSTHSAHS THAGHAGHTS LPQCINPFTN
       130        140        150        160        170        180
LPHTPRYYDI LKKRLQLPVW EYKDRFTDIL VRHQSFVLVG ETGSGKTTQI PQWCVEYMRS
       190        200        210        220        230        240
LPGPKRGVAC TQPRRVAAMS VAQRVADEMD VMLGQEVGYS IRFEDCSSAK TILKYMTDGM
       250        260        270        280        290        300
LLREAMNDPL LERYGVIILD EAHERTLATD ILMGVLKEVV RQRSDLKVIV MSATLDAGKF
       310        320        330        340        350        360
QIYFDNCPLL TIPGRTHPVE IFYTPEPERD YLEAAIRTVI QIHMCEEEEG DLLLFLTGQE
       370        380        390        400        410        420
EIDEACKRIK REVDDLGPEV GDIKIIPLYS TLPPQQQQRI FEPPPPKKQN GAIGRKVVVS
       430        440        450        460        470        480
TNIAETSLTI DGVVFVIDPG FAKQKVYNPR IRVESLLVTA ISKASAQQRA GRAGRTRPGK
       490        500        510        520        530        540
CFRLYTEKAY KTEMQDNTYP EILRSNLGSV VLQLKKLGID DLVHFDFMDP PAPETLMRAL
       550        560        570        580        590        600
ELLNYLAALN DDGDLTELGS MMAEFPLDPQ LAKMVIASCD YNCSNEVLSI TAMLSVPQCF
       610        620        630        640        650        660
VRPTEAKKAA DEAKMRFAHI DGDHLTLLNV YHAFKQNHES VQWCYDNFIN YRSLMSADNV
       670        680        690        700        710        720
RQQLSRIMDR FNLPRRSTDF TSRDYYINIR KALVTGYFMQ VAHLERTGHY LTVKDNQVVQ
       730        740        750        760        770        780
LHPSTVLDHK PEWVLYNEFV LTTKNYIRTC TDIKPEWLVK IAPQYYDMSN FPQCEAKRQL
       790
DRIIAKLQSK EYSQY

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O43143-1-unknown	MSKRHR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43143-7-unknown	LDLGED...	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18224
O43143-7-unknown	LDLGED...	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16874
O43143-8-unknown	DLGEDY...	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13733
O43143-752-unknown	DIKPEW...	752	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16875

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SKRHRL	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18224
...SKRHRL	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16874
...KRHRLD	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13733
...IRTCTD	751	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16875
...EYSQY	795	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EYSQY	795		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EYSQY	795		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EYSQY	795		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EYSQY	795		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	6	RHRL.\|.LDLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	6	RHRL.\|.LDLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	7	HRLD.\|.DLGE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	751	TCTD.\|.DIKP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)