Q06033: Inter-alpha-trypsin inhibitor heavy chain H3
Protein names | - Inter-alpha-trypsin inhibitor heavy chain H3 - ITI heavy chain H3 - ITI-HC3 - Inter-alpha-inhibitor heavy chain 3 - Serum-derived hyaluronan-associated protein - SHAP |
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Gene names | ITIH3 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q06033 |
5
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAFAWWPCLI LALLSSLAAS GFPRSPFRLL GKRSLPEGVA NGIEVYSTKI NSKVTSRFAH
70 80 90 100 110 120
NVVTMRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT YPGNVKEKEV AKKQYEKAVS
130 140 150 160 170 180
QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV TFELTYEELL KRHKGKYEMY LKVQPKQLVK
190 200 210 220 230 240
HFEIEVDIFE PQGISMLDAE ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT
250 260 270 280 290 300
DSLLNGDFTI TYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNVAFVID ISGSMAGRKL
310 320 330 340 350 360
EQTKEALLRI LEDMQEEDYL NFILFSGDVS TWKEHLVQAT PENLQEARTF VKSMEDKGMT
370 380 390 400 410 420
NINDGLLRGI SMLNKAREEH RIPERSTSIV IMLTDGDANV GESRPEKIQE NVRNAIGGKF
430 440 450 460 470 480
PLYNLGFGNN LNYNFLENMA LENHGFARRI YEDSDADLQL QGFYEEVANP LLTGVEMEYP
490 500 510 520 530 540
ENAILDLTQN TYQHFYDGSE IVVAGRLVDE DMNSFKADVK GHGATNDLTF TEEVDMKEME
550 560 570 580 590 600
KALQERDYIF GNYIERLWAY LTIEQLLEKR KNAHGEEKEN LTARALDLSL KYHFVTPLTS
610 620 630 640 650 660
MVVTKPEDNE DERAIADKPG EDAEATPVSP AMSYLTSYQP PQNPYYYVDG DPHFIIQIPE
670 680 690 700 710 720
KDDALCFNID EAPGTVLRLI QDAVTGLTVN GQITGDKRGS PDSKTRKTYF GKLGIANAQM
730 740 750 760 770 780
DFQVEVTTEK ITLWNRAVPS TFSWLDTVTV TQDGLSMMIN RKNMVVSFGD GVTFVVVLHQ
790 800 810 820 830 840
VWKKHPVHRD FLGFYVVDSH RMSAQTHGLL GQFFQPFDFK VSDIRPGSDP TKPDATLVVK
850 860 870 880 890
NHQLIVTRGS QKDYRKDASI GTKVVCWFVH NNGEGLIDGV HTDYIVPNLF
Isoforms
- Isoform 2 of Inter-alpha-trypsin inhibitor heavy chain H3Sequence View
10 20 30 40 50 60
MAFAWWPCLI LALLSSLAAS GFPRSPFRLL GKRSLPEGVA NGIEVYSTKI NSKVTSRFAH
70 80 90 100 110 120
NVVTMRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT YPGNVKEKEV AKKQYEKAVS
130 140 150 160 170 180
QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV TFELTYEELL KRHKGKYEMY LKVQPKQLVK
190 200 210 220 230 240
HFEIEVDIFE PQGISMLDAE ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT
250 260 270 280 290 300
DSLLNGDFTI TYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNVAFVID ISGSMAGRKL
310 320 330 340 350 360
EQTKEALLRI LEDMQEEDYL NFILFSGDVS TWKEHLVQAT PENLQEARTF VKSMEDKGMT
370 380 390 400 410 420
NINDGLLRGI SMLNKAREEH RIPERSTSIV IMLTDGDANV GESRPEKIQE NVRNAIGGKF
430 440 450 460 470 480
PLYNLGFGNN LNYNFLENMA LENHGFARRI YEDSDADLQL QGFYEEVANP LLTGVEMEYP
490 500 510 520 530 540
ENAILDLTQN TYQHFYDGSE IVVAGRLVDE DMNSFKADVK GHGATNDLTF TEEVDMKEME
550 560 570 580 590 600
KALQERDYIF GNYIERLWAY LTIEQLLEKR KNAHGEEKEN LTARALDLSL KYHFVTPLTS
610 620 630 640 650 660
MVVTKPEDNE DERAIADKPG EDAEATPVSP AMSYLTSYQP PQNPYYYVDG DPHFIIQIPE
670 680 690 700 710 720
KDDALCFNID EAPGTVLRLI QDAVTGLTVN GQITGDKRGS PDSKTRKTYF GKLGIANAQM
730 740 750 760 770 780
DFQVEVTTEK ITLWNRAVPS TFSWLDTVTV TQDGLSMMIN RKNMVVSFGD GVTFVVVLHQ
790 800 810 820 830 840
VWKKHPVHRD FLGFYVVDSH RMSAQTHGLL GQFFQPFDFK VSDIRPGSDP TKPDATLVVK
850 860 870 880 890
NHQLIVTRGS QKDYRKDASI GTKVVCWFVH NNGEGLIDGV HTDYIVPNLF
Protein Neighborhood
Domains & Features
5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q06033-21-unknown | GFPRSP... | 21 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q06033-34-unknown | SLPEGV... | 34 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16377 | |||
Q06033-34-unknown | SLPEGV... | 34 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
Q06033-34-unknown | SLPEGV... | 34 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137576 | |||
Q06033-35-unknown | LPEGVA... | 35 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q06033-35-unknown | LPEGVA... | 35 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115222 | |||
Q06033-118-unknown | AVSQGK... | 118 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
Q06033-118-unknown | AVSQGK... | 118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180518 | |||
Q06033-527-unknown | DLTFTE... | 527 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19353 | |||
Q06033-527-unknown | DLTFTE... | 527 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17854 | |||
Q06033-527-unknown | DLTFTE... | 527 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153651 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LLGKRS | 33 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16377 | |||
...HGATND | 526 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19353 | |||
...HGATND | 526 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17854 | |||
...HGATND | 526 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137075 | |||
...YVDGDP | 651 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...YVDGDP | 651 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93183 | |||
...VPNLF | 890 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73817 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
KLK4_HUMAN | 33 | GKRS.|.SLPE | inferred from experiment | unknown | MEROPS | Nelson PS | Matsumura M et al.:Substrates of the prostate-spec... (S01.251) | 15389820, |
MEP1B_HUMAN | 526 | ATND.|.DLTF | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
MEP1A_HUMAN | 526 | ATND.|.DLTF | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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