Q06033: Inter-alpha-trypsin inhibitor heavy chain H3

General Information

Protein names	- Inter-alpha-trypsin inhibitor heavy chain H3 - ITI heavy chain H3 - ITI-HC3 - Inter-alpha-inhibitor heavy chain 3 - Serum-derived hyaluronan-associated protein - SHAP
Gene names	ITIH3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q06033

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAFAWWPCLI LALLSSLAAS GFPRSPFRLL GKRSLPEGVA NGIEVYSTKI NSKVTSRFAH
        70         80         90        100        110        120
NVVTMRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT YPGNVKEKEV AKKQYEKAVS
       130        140        150        160        170        180
QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV TFELTYEELL KRHKGKYEMY LKVQPKQLVK
       190        200        210        220        230        240
HFEIEVDIFE PQGISMLDAE ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT
       250        260        270        280        290        300
DSLLNGDFTI TYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNVAFVID ISGSMAGRKL
       310        320        330        340        350        360
EQTKEALLRI LEDMQEEDYL NFILFSGDVS TWKEHLVQAT PENLQEARTF VKSMEDKGMT
       370        380        390        400        410        420
NINDGLLRGI SMLNKAREEH RIPERSTSIV IMLTDGDANV GESRPEKIQE NVRNAIGGKF
       430        440        450        460        470        480
PLYNLGFGNN LNYNFLENMA LENHGFARRI YEDSDADLQL QGFYEEVANP LLTGVEMEYP
       490        500        510        520        530        540
ENAILDLTQN TYQHFYDGSE IVVAGRLVDE DMNSFKADVK GHGATNDLTF TEEVDMKEME
       550        560        570        580        590        600
KALQERDYIF GNYIERLWAY LTIEQLLEKR KNAHGEEKEN LTARALDLSL KYHFVTPLTS
       610        620        630        640        650        660
MVVTKPEDNE DERAIADKPG EDAEATPVSP AMSYLTSYQP PQNPYYYVDG DPHFIIQIPE
       670        680        690        700        710        720
KDDALCFNID EAPGTVLRLI QDAVTGLTVN GQITGDKRGS PDSKTRKTYF GKLGIANAQM
       730        740        750        760        770        780
DFQVEVTTEK ITLWNRAVPS TFSWLDTVTV TQDGLSMMIN RKNMVVSFGD GVTFVVVLHQ
       790        800        810        820        830        840
VWKKHPVHRD FLGFYVVDSH RMSAQTHGLL GQFFQPFDFK VSDIRPGSDP TKPDATLVVK
       850        860        870        880        890
NHQLIVTRGS QKDYRKDASI GTKVVCWFVH NNGEGLIDGV HTDYIVPNLF

Isoforms

- Isoform 2 of Inter-alpha-trypsin inhibitor heavy chain H3

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
Q06033-21-unknown	GFPRSP...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q06033-34-unknown	SLPEGV...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16377
Q06033-34-unknown	SLPEGV...	34		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
Q06033-34-unknown	SLPEGV...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137576
Q06033-35-unknown	LPEGVA...	35	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q06033-35-unknown	LPEGVA...	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115222
Q06033-118-unknown	AVSQGK...	118		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
Q06033-118-unknown	AVSQGK...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180518
Q06033-527-unknown	DLTFTE...	527	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19353
Q06033-527-unknown	DLTFTE...	527	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17854
Q06033-527-unknown	DLTFTE...	527	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153651

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LLGKRS	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16377
...HGATND	526	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19353
...HGATND	526	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17854
...HGATND	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137075
...YVDGDP	651	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YVDGDP	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93183
...VPNLF	890	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73817

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	33	GKRS.\|.SLPE	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
MEP1B_HUMAN	526	ATND.\|.DLTF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	526	ATND.\|.DLTF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)