P09651: Heterogeneous nuclear ribonucleoprotein A1

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein A1 - hnRNP A1 - Helix-destabilizing protein - Single-strand RNA-binding protein - hnRNP core protein A1 - Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
Gene names	HNRNPA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P09651

37 N-termini

16 C-termini

16 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform A1-A of Heterogeneous nuclear ribonucleoprotein A1 - Isoform 2 of Heterogeneous nuclear ribonucleoprotein A1

Sequence View

        10         20         30         40         50         60
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
        70         80         90        100        110        120
TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH
       130        140        150        160        170        180
LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA
       190        200        210        220        230        240
LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS
       250        260        270        280        290        300
GDGYNGFGND GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG
       310        320        330        340        350        360
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK PRNQGGYGGS
       370
SSSSSYGSGR RF         10         20         30         40         50         60
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
        70         80         90        100        110        120
TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH
       130        140        150        160        170        180
LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA
       190        200        210        220        230        240
LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS
       250        260        270        280        290        300
GDGYNGFGND GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG
       310        320        330        340        350        360
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK PRNQGGYGGS
       370
SSSSSYGSGR RF

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

37 N-termini - 16 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P09651-1-Acetylation	MSKSES...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09651-1-Acetylation	MSKSES...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P09651-1-Acetylation	MSKSES...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P09651-1-Acetylation	MSKSES...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100179
P09651-1-Acetylation	MSKSES...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100180
P09651-1-unknown	MSKSES...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88048
P09651-1-unknown	MSKSES...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88049
P09651-2-Acetylation	SKSESP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09651-2-Acetylation	SKSESP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P09651-2-Acetylation	SKSESP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P09651-2-Acetylation	SKSESP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09651-2-Acetylation	SKSESP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110592
P09651-2-Acetylation	SKSESP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110593
P09651-4-unknown	SESPKE...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9955
P09651-4-unknown	SESPKE...	4			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P09651-4-unknown	SESPKE...	4		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162019
P09651-4-unknown	SESPKE...	4		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162020
P09651-4-	SESPKE...	4			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P09651-4-	SESPKE...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09651-4-	SESPKE...	4			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P09651-4-	SESPKE...	4			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P09651-7-unknown	PKEPEQ...	7		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P09651-7-unknown	PKEPEQ...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194749
P09651-7-unknown	PKEPEQ...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194750
P09651-18-unknown	IGGLSF...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5515
P09651-18-unknown	IGGLSF...	18		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136726
P09651-18-unknown	IGGLSF...	18		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136727
P09651-20-unknown	GLSFET...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7261
P09651-20-unknown	GLSFET...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136844
P09651-20-unknown	GLSFET...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136845
P09651-22-	SFETTD...	22			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09651-22-unknown	SFETTD...	22		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171404
P09651-22-unknown	SFETTD...	22		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171405
P09651-56-unknown	GFGFVT...	56		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173279
P09651-56-unknown	GFGFVT...	56		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173280
P09651-56-	GFGFVT...	56			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09651-59-unknown	FVTYAT...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173282
P09651-59-unknown	FVTYAT...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173283
P09651-59-	FVTYAT...	59			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09651-67-unknown	EVDAAM...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18620
P09651-67-unknown	EVDAAM...	67		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140456
P09651-67-unknown	EVDAAM...	67		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140457
P09651-70-unknown	AAMNAR...	70		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166609
P09651-70-unknown	AAMNAR...	70		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166610
P09651-70-	AAMNAR...	70			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P09651-70-	AAMNAR...	70			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09651-70-	AAMNAR...	70			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P09651-126-unknown	EQYGKI...	126		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18623
P09651-126-unknown	EQYGKI...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143746
P09651-126-unknown	EQYGKI...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143747
P09651-147-	GFAFVT...	147			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09651-147-	GFAFVT...	147			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P09651-147-unknown	GFAFVT...	147		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171407
P09651-147-unknown	GFAFVT...	147		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171408
P09651-150-unknown	FVTFDD...	150		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3548
P09651-150-unknown	FVTFDD...	150		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144755
P09651-150-unknown	FVTFDD...	150		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144756
P09651-151-unknown	VTFDDH...	151		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5518
P09651-151-unknown	VTFDDH...	151		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144784
P09651-151-unknown	VTFDDH...	151		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144785
P09651-157-unknown	DSVDKI...	157		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18626
P09651-157-unknown	DSVDKI...	157		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145050
P09651-157-unknown	DSVDKI...	157		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145051
P09651-188-unknown	SASSSQ...	188		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13947
P09651-188-unknown	SASSSQ...	188		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146181
P09651-197-unknown	SGSGNF...	197		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11153
P09651-197-unknown	SGSGNF...	197		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146497
P09651-289-unknown	SYNNGG...	289		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1620
P09651-308-unknown	GGGSYN...	308		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7264
P09651-308-unknown	GGGSYN...	308		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198897
P09651-308-unknown	GGGSYN...	308		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198898
P09651-311-	SYNDFG...	311			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P09651-311-unknown	SYNDFG...	311		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166602
P09651-311-unknown	SYNDFG...	311		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166603
P09651-314-unknown	DFGNYN...	314		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18629
P09651-314-unknown	DFGNYN...	314		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148898
P09651-314-unknown	DFGNYN...	314		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198562
P09651-315-unknown	FGNYNN...	315		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1621
P09651-315-unknown	FGNYNN...	315		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148918
P09651-315-unknown	FGNYNN...	315		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198571
P09651-319-unknown	NNQSSN...	319		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11155
P09651-319-unknown	NNQSSN...	319		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147145
P09651-319-unknown	NNQSSN...	319		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149052
P09651-322-unknown	SSNFGP...	322		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166606
P09651-322-unknown	SSNFGP...	322		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166607
P09651-322-	SSNFGP...	322			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P09651-337-	SSGPYG...	337			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P09651-337-	SSGPYG...	337			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P09651-337-	SSGPYG...	337			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P09651-337-	SSGPYG...	337			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P09651-337-	SSGPYG...	337			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P09651-337-	SSGPYG...	337			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P09651-337-unknown	SSGPYG...	337			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P09651-337-unknown	SSGPYG...	337		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162022
P09651-337-unknown	SSGPYG...	337		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162023
P09651-353-unknown	NQGGYG...	353		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9956
P09651-353-unknown	NQGGYG...	353		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148370
P09651-353-unknown	NQGGYG...	353		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149907

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRKLFI	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5515
...KLFIGG	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7261
...YATVEE	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18620
...YATVEE	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123583
...YATVEE	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123584
...LRDYFE	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18623
...LRDYFE	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126989
...LRDYFE	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126990
...KRGFAF	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3548
...KRGFAF	149	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128030
...KRGFAF	149	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128031
...RGFAFV	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5518
...RGFAFV	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128059
...RGFAFV	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128060
...TFDDHD	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18626
...TFDDHD	156	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128329
...TFDDHD	156	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128330
...KQEMAS	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13947
...KQEMAS	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129483
...KQEMAS	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129484
...SQRGRS	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11153
...SQRGRS	196	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129805
...SQRGRS	196	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155567
...SGSYDS	288	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1620
...GSNFGG	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7264
...GGSYND	313	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18629
...GSYNDF	314	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1621
...DFGNYN	318	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11155
...FAKPRN	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9956
...FAKPRN	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131742
...FAKPRN	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133299
...SGRRF	372	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SGRRF	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83667
...SGRRF	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83666

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	3	MSKS.\|.SESP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	17	KLFI.\|.IGGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	19	FIGG.\|.GLSF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	66	TVEE.\|.EVDA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	125	DYFE.\|.EQYG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	149	GFAF.\|.FVTF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	150	FAFV.\|.VTFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	156	DDHD.\|.DSVD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	187	EMAS.\|.SASS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	196	RGRS.\|.SGSG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	288	SYDS.\|.SYNN	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CATS_HUMAN	307	NFGG.\|.GGGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	313	SYND.\|.DFGN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	314	YNDF.\|.FGNY	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
GRAB_HUMAN	318	GNYN.\|.NNQS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	352	KPRN.\|.NQGG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)