P53675: Clathrin heavy chain 2

General Information

Protein names	- Clathrin heavy chain 2 - Clathrin heavy chain on chromosome 22 - CLH-22
Gene names	CLTCL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P53675

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQILPVRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV TIIDMSDPMA
        70         80         90        100        110        120
PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMAEEVIF WKWVSVNTVA
       130        140        150        160        170        180
LVTETAVYHW SMEGDSQPMK MFDRHTSLVG CQVIHYRTDE YQKWLLLVGI SAQQNRVVGA
       190        200        210        220        230        240
MQLYSVDRKV SQPIEGHAAA FAEFKMEGNA KPATLFCFAV RNPTGGKLHI IEVGQPAAGN
       250        260        270        280        290        300
QPFVKKAVDV FFPPEAQNDF PVAMQIGAKH GVIYLITKYG YLHLYDLESG VCICMNRISA
       310        320        330        340        350        360
DTIFVTAPHK PTSGIIGVNK KGQVLSVCVE EDNIVNYATN VLQNPDLGLR LAVRSNLAGA
       370        380        390        400        410        420
EKLFVRKFNT LFAQGSYAEA AKVAASAPKG ILRTRETVQK FQSIPAQSGQ ASPLLQYFGI
       430        440        450        460        470        480
LLDQGQLNKL ESLELCHLVL QQGRKQLLEK WLKEDKLECS EELGDLVKTT DPMLALSVYL
       490        500        510        520        530        540
RANVPSKVIQ CFAETGQFQK IVLYAKKVGY TPDWIFLLRG VMKISPEQGL QFSRMLVQDE
       550        560        570        580        590        600
EPLANISQIV DIFMENSLIQ QCTSFLLDAL KNNRPAEGLL QTWLLEMNLV HAPQVADAIL
       610        620        630        640        650        660
GNKMFTHYDR AHIAQLCEKA GLLQQALEHY TDLYDIKRAV VHTHLLNPEW LVNFFGSLSV
       670        680        690        700        710        720
EDSVECLHAM LSANIRQNLQ LCVQVASKYH EQLGTQALVE LFESFKSYKG LFYFLGSIVN
       730        740        750        760        770        780
FSQDPDVHLK YIQAACKTGQ IKEVERICRE SSCYNPERVK NFLKEAKLTD QLPLIIVCDR
       790        800        810        820        830        840
FGFVHDLVLY LYRNNLQRYI EIYVQKVNPS RTPAVIGGLL DVDCSEEVIK HLIMAVRGQF
       850        860        870        880        890        900
STDELVAEVE KRNRLKLLLP WLESQIQEGC EEPATHNALA KIYIDSNNSP ECFLRENAYY
       910        920        930        940        950        960
DSSVVGRYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVCR KDPELWAHVL
       970        980        990       1000       1010       1020
EETNPSRRQL IDQVVQTALS ETRDPEEISV TVKAFMTADL PNELIELLEK IVLDNSVFSE
      1030       1040       1050       1060       1070       1080
HRNLQNLLIL TAIKADRTRV MEYISRLDNY DALDIASIAV SSALYEEAFT VFHKFDMNAS
      1090       1100       1110       1120       1130       1140
AIQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAQAQLQKDL VKEAINSYIR GDDPSSYLEV
      1150       1160       1170       1180       1190       1200
VQSASRSNNW EDLVKFLQMA RKKGRESYIE TELIFALAKT SRVSELEDFI NGPNNAHIQQ
      1210       1220       1230       1240       1250       1260
VGDRCYEEGM YEAAKLLYSN VSNFARLAST LVHLGEYQAA VDNSRKASST RTWKEVCFAC
      1270       1280       1290       1300       1310       1320
MDGQEFRFAQ LCGLHIVIHA DELEELMCYY QDRGYFEELI LLLEAALGLE RAHMGMFTEL
      1330       1340       1350       1360       1370       1380
AILYSKFKPQ KMLEHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAVLTMMS
      1390       1400       1410       1420       1430       1440
HPTEAWKEGQ FKDIITKVAN VELCYRALQF YLDYKPLLIN DLLLVLSPRL DHTWTVSFFS
      1450       1460       1470       1480       1490       1500
KAGQLPLVKP YLRSVQSHNN KSVNEALNHL LTEEEDYQGL RASIDAYDNF DNISLAQQLE
      1510       1520       1530       1540       1550       1560
KHQLMEFRCI AAYLYKGNNW WAQSVELCKK DHLYKDAMQH AAESRDAELA QKLLQWFLEE
      1570       1580       1590       1600       1610       1620
GKRECFAACL FTCYDLLRPD MVLELAWRHN LVDLAMPYFI QVMREYLSKV DKLDALESLR
      1630       1640
KQEEHVTEPA PLVFDFDGHE

Isoforms

- Isoform 2 of Clathrin heavy chain 2

Sequence View

        10         20         30         40         50         60
MAQILPVRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV TIIDMSDPMA
        70         80         90        100        110        120
PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMAEEVIF WKWVSVNTVA
       130        140        150        160        170        180
LVTETAVYHW SMEGDSQPMK MFDRHTSLVG CQVIHYRTDE YQKWLLLVGI SAQQNRVVGA
       190        200        210        220        230        240
MQLYSVDRKV SQPIEGHAAA FAEFKMEGNA KPATLFCFAV RNPTGGKLHI IEVGQPAAGN
       250        260        270        280        290        300
QPFVKKAVDV FFPPEAQNDF PVAMQIGAKH GVIYLITKYG YLHLYDLESG VCICMNRISA
       310        320        330        340        350        360
DTIFVTAPHK PTSGIIGVNK KGQVLSVCVE EDNIVNYATN VLQNPDLGLR LAVRSNLAGA
       370        380        390        400        410        420
EKLFVRKFNT LFAQGSYAEA AKVAASAPKG ILRTRETVQK FQSIPAQSGQ ASPLLQYFGI
       430        440        450        460        470        480
LLDQGQLNKL ESLELCHLVL QQGRKQLLEK WLKEDKLECS EELGDLVKTT DPMLALSVYL
       490        500        510        520        530        540
RANVPSKVIQ CFAETGQFQK IVLYAKKVGY TPDWIFLLRG VMKISPEQGL QFSRMLVQDE
       550        560        570        580        590        600
EPLANISQIV DIFMENSLIQ QCTSFLLDAL KNNRPAEGLL QTWLLEMNLV HAPQVADAIL
       610        620        630        640        650        660
GNKMFTHYDR AHIAQLCEKA GLLQQALEHY TDLYDIKRAV VHTHLLNPEW LVNFFGSLSV
       670        680        690        700        710        720
EDSVECLHAM LSANIRQNLQ LCVQVASKYH EQLGTQALVE LFESFKSYKG LFYFLGSIVN
       730        740        750        760        770        780
FSQDPDVHLK YIQAACKTGQ IKEVERICRE SSCYNPERVK NFLKEAKLTD QLPLIIVCDR
       790        800        810        820        830        840
FGFVHDLVLY LYRNNLQRYI EIYVQKVNPS RTPAVIGGLL DVDCSEEVIK HLIMAVRGQF
       850        860        870        880        890        900
STDELVAEVE KRNRLKLLLP WLESQIQEGC EEPATHNALA KIYIDSNNSP ECFLRENAYY
       910        920        930        940        950        960
DSSVVGRYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVCR KDPELWAHVL
       970        980        990       1000       1010       1020
EETNPSRRQL IDQVVQTALS ETRDPEEISV TVKAFMTADL PNELIELLEK IVLDNSVFSE
      1030       1040       1050       1060       1070       1080
HRNLQNLLIL TAIKADRTRV MEYISRLDNY DALDIASIAV SSALYEEAFT VFHKFDMNAS
      1090       1100       1110       1120       1130       1140
AIQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAQAQLQKDL VKEAINSYIR GDDPSSYLEV
      1150       1160       1170       1180       1190       1200
VQSASRSNNW EDLVKFLQMA RKKGRESYIE TELIFALAKT SRVSELEDFI NGPNNAHIQQ
      1210       1220       1230       1240       1250       1260
VGDRCYEEGM YEAAKLLYSN VSNFARLAST LVHLGEYQAA VDNSRKASST RTWKEVCFAC
      1270       1280       1290       1300       1310       1320
MDGQEFRFAQ LCGLHIVIHA DELEELMCYY QDRGYFEELI LLLEAALGLE RAHMGMFTEL
      1330       1340       1350       1360       1370       1380
AILYSKFKPQ KMLEHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAVLTMMS
      1390       1400       1410       1420       1430       1440
HPTEAWKEGQ FKDIITKVAN VELCYRALQF YLDYKPLLIN DLLLVLSPRL DHTWTVSFFS
      1450       1460       1470       1480       1490       1500
KAGQLPLVKP YLRSVQSHNN KSVNEALNHL LTEEEDYQGL RASIDAYDNF DNISLAQQLE
      1510       1520       1530       1540       1550       1560
KHQLMEFRCI AAYLYKGNNW WAQSVELCKK DHLYKDAMQH AAESRDAELA QKLLQWFLEE
      1570       1580       1590       1600       1610       1620
GKRECFAACL FTCYDLLRPD MVLELAWRHN LVDLAMPYFI QVMREYLSKV DKLDALESLR
      1630       1640
KQEEHVTEPA PLVFDFDGHE

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P53675-1-unknown	MAQILP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53675-1-unknown	MAQILP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70958
P53675-507-	KVGYTP...	507		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P53675-507-	KVGYTP...	507		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P53675-507-unknown	KVGYTP...	507	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164634
P53675-841-unknown	STDELV...	841	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17724
P53675-841-unknown	STDELV...	841	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156653
P53675-872-unknown	EPATHN...	872	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19199
P53675-872-unknown	EPATHN...	872	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156755
P53675-1088-unknown	HIGNLD...	1088	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3860
P53675-1088-unknown	HIGNLD...	1088	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157344

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VRGQFS	840	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17724
...VRGQFS	840	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140138
...QEGCEE	871	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19199
...QEGCEE	871	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140245
...QVLIEH	1087	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3860
...QVLIEH	1087	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140843
...FDGHE	1640	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FDGHE	1640	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66576

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	840	GQFS.\|.STDE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	871	GCEE.\|.EPAT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	1087	LIEH.\|.HIGN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

TopFIND

P53675: Clathrin heavy chain 2

General Information

6

N-termini

4

C-termini

3

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates