Q13263: Transcription intermediary factor 1-beta

General Information

Protein names	- Transcription intermediary factor 1-beta - TIF1-beta - E3 SUMO-protein ligase TRIM28 - 2.3.2.27 - KRAB-associated protein 1 - KAP-1 - KRAB-interacting protein 1 - KRIP-1 - Nuclear corepressor KAP-1 - RING finger protein 96 - RING-type E3 ubiquitin transferase TIF1-beta {ECO:0000305} - Tripartite motif-containing protein 28
Gene names	TRIM28
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13263

61 N-termini

20 C-termini

26 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAASAAAASA AAASAASGSP GPGEGSAGGE KRSTAPSAAA SASASAAASS PAGGGAEALE
        70         80         90        100        110        120
LLEHCGVCRE RLRPEREPRL LPCLHSACSA CLGPAAPAAA NSSGDGGAAG DGTVVDCPVC
       130        140        150        160        170        180
KQQCFSKDIV ENYFMRDSGS KAATDAQDAN QCCTSCEDNA PATSYCVECS EPLCETCVEA
       190        200        210        220        230        240
HQRVKYTKDH TVRSTGPAKS RDGERTVYCN VHKHEPLVLF CESCDTLTCR DCQLNAHKDH
       250        260        270        280        290        300
QYQFLEDAVR NQRKLLASLV KRLGDKHATL QKSTKEVRSS IRQVSDVQKR VQVDVKMAIL
       310        320        330        340        350        360
QIMKELNKRG RVLVNDAQKV TEGQQERLER QHWTMTKIQK HQEHILRFAS WALESDNNTA
       370        380        390        400        410        420
LLLSKKLIYF QLHRALKMIV DPVEPHGEMK FQWDLNAWTK SAEAFGKIVA ERPGTNSTGP
       430        440        450        460        470        480
APMAPPRAPG PLSKQGSGSS QPMEVQEGYG FGSGDDPYSS AEPHVSGVKR SRSGEGEVSG
       490        500        510        520        530        540
LMRKVPRVSL ERLDLDLTAD SQPPVFKVFP GSTTEDYNLI VIERGAAAAA TGQPGTAPAG
       550        560        570        580        590        600
TPGAPPLAGM AIVKEEETEA AIGAPPTATE GPETKPVLMA LAEGPGAEGP RLASPSGSTS
       610        620        630        640        650        660
SGLEVVAPEG TSAPGGGPGT LDDSATICRV CQKPGDLVMC NQCEFCFHLD CHLPALQDVP
       670        680        690        700        710        720
GEEWSCSLCH VLPDLKEEDG SLSLDGADST GVVAKLSPAN QRKCERVLLA LFCHEPCRPL
       730        740        750        760        770        780
HQLATDSTFS LDQPGGTLDL TLIRARLQEK LSPPYSSPQE FAQDVGRMFK QFNKLTEDKA
       790        800        810        820        830
DVQSIIGLQR FFETRMNEAF GDTKFSAVLV EPPPMSLPGA GLSSQELSGG PGDGP

Isoforms

- Isoform 2 of Transcription intermediary factor 1-beta

Sequence View

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Evidence Codes:

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Protein Neighborhood

Domains & Features

61 N-termini - 20 C-termini - 26 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13263-2-unknown	MAASAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13263-1-unknown	MAASAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92163
Q13263-2-Acetylation	AASAAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13263-2-Acetylation	AASAAA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13263-2-Acetylation	AASAAA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q13263-2-Acetylation	AASAAA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13263-2-Acetylation	AASAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110641
Q13263-4-unknown	SAAAAS...	4		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172166
Q13263-4-	SAAAAS...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-7-unknown	AASAAA...	7			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13263-7-unknown	AASAAA...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162221
Q13263-7-	AASAAA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13263-7-	AASAAA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13263-7-	AASAAA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-7-	AASAAA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13263-7-	AASAAA...	7			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-9-unknown	SAAAAS...	9		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166357
Q13263-9-	SAAAAS...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13263-9-	SAAAAS...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-9-	SAAAAS...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13263-9-	SAAAAS...	9			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-11-unknown	AAASAA...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177550
Q13263-11-	AAASAA...	11			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-12-	AASAAS...	12			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-12-	AASAAS...	12			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-12-unknown	AASAAS...	12		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172164
Q13263-14-unknown	SAASGS...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173013
Q13263-14-	SAASGS...	14			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-14-	SAASGS...	14			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-16-unknown	ASGSPG...	16		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3981
Q13263-16-unknown	ASGSPG...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136593
Q13263-17-unknown	SGSPGP...	17		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6313
Q13263-17-unknown	SGSPGP...	17		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136652
Q13263-18-unknown	GSPGPG...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19413
Q13263-18-unknown	GSPGPG...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17887
Q13263-18-unknown	GSPGPG...	18		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136740
Q13263-19-unknown	SPGPGE...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7762
Q13263-19-unknown	SPGPGE...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3983
Q13263-19-unknown	SPGPGE...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6315
Q13263-19-unknown	SPGPGE...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17889
Q13263-19-unknown	SPGPGE...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136779
Q13263-50-unknown	SPAGGG...	50		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19415
Q13263-50-unknown	SPAGGG...	50		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17891
Q13263-50-unknown	SPAGGG...	50		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139213
Q13263-58-unknown	ALELLE...	58		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17893
Q13263-58-unknown	ALELLE...	58		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139778
Q13263-59-unknown	LELLEH...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19417
Q13263-59-unknown	LELLEH...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139853
Q13263-185-unknown	KYTKDH...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15393
Q13263-218-unknown	VLFCES...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14404
Q13263-218-unknown	VLFCES...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144116
Q13263-279-unknown	SSIRQV...	279		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177552
Q13263-279-	SSIRQV...	279			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-317-unknown	AQKVTE...	317		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12009
Q13263-317-unknown	AQKVTE...	317		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147933
Q13263-411-unknown	ERPGTN...	411		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6317
Q13263-411-unknown	ERPGTN...	411		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150510
Q13263-417-unknown	STGPAP...	417		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166354
Q13263-417-	STGPAP...	417			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13263-417-	STGPAP...	417			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13263-417-	STGPAP...	417			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-417-	STGPAP...	417			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13263-417-	STGPAP...	417			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q13263-417-	STGPAP...	417			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13263-417-	STGPAP...	417			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-450-unknown	GFGSGD...	450		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173017
Q13263-450-	GFGSGD...	450			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-460-unknown	SAEPHV...	460		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7764
Q13263-460-unknown	SAEPHV...	460		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6319
Q13263-460-unknown	SAEPHV...	460		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151572
Q13263-508-unknown	VFPGST...	508		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176497
Q13263-508-	VFPGST...	508			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q13263-508-	VFPGST...	508			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-532-unknown	GQPGTA...	532		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177548
Q13263-532-	GQPGTA...	532			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-551-	AIVKEE...	551			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-551-unknown	AIVKEE...	551		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170370
Q13263-560-	AAIGAP...	560			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13263-560-unknown	AAIGAP...	560		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174897
Q13263-579-unknown	MALAEG...	579		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174899
Q13263-579-	MALAEG...	579			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13263-579-	MALAEG...	579			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-580-unknown	ALAEGP...	580		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12011
Q13263-580-unknown	ALAEGP...	580			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13263-580-unknown	ALAEGP...	580		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153392
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13263-580-	ALAEGP...	580			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-581-unknown	LAEGPG...	581		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170372
Q13263-581-	LAEGPG...	581			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-581-	LAEGPG...	581			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-582-unknown	AEGPGA...	582		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173015
Q13263-582-	AEGPGA...	582			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-582-	AEGPGA...	582			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-675-unknown	LKEEDG...	675		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12013
Q13263-675-unknown	LKEEDG...	675		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154509
Q13263-686-unknown	GADSTG...	686			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13263-686-unknown	GADSTG...	686		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162223
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13263-686-	GADSTG...	686			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-689-unknown	STGVVA...	689		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2169
Q13263-689-unknown	STGVVA...	689		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154700
Q13263-689-	STGVVA...	689			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13263-689-	STGVVA...	689			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13263-689-	STGVVA...	689			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-727-	STFSLD...	727			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13263-727-	STFSLD...	727			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13263-727-	STFSLD...	727			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13263-727-	STFSLD...	727			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13263-727-unknown	STFSLD...	727		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12015
Q13263-727-unknown	STFSLD...	727		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155245
Q13263-728-unknown	TFSLDQ...	728		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177370
Q13263-728-	TFSLDQ...	728			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q13263-736-unknown	GTLDLT...	736		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12017
Q13263-736-unknown	GTLDLT...	736		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155371
Q13263-757-unknown	SPQEFA...	757		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7766
Q13263-757-unknown	SPQEFA...	757		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6321
Q13263-757-unknown	SPQEFA...	757		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155603
Q13263-778-unknown	DKADVQ...	778		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19419
Q13263-778-unknown	DKADVQ...	778		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155830

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AAASAA	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3981
...AASAAS	16	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6313
...ASAASG	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19413
...ASAASG	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17887
...SAASGS	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7762
...SAASGS	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3983
...SAASGS	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6315
...SAASGS	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17889
...SAAASS	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19415
...SAAASS	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17891
...SAAASS	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122288
...GGGAEA	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17893
...GGGAEA	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122877
...GGAEAL	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19417
...GGAEAL	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122953
...AHQRVK	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15393
...KHEPLV	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14404
...KHEPLV	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127367
...VLVNDA	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12009
...VLVNDA	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131294
...GKIVAE	410	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6317
...GKIVAE	410	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133906
...DDPYSS	459	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7764
...DDPYSS	459	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6319
...DDPYSS	459	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134977
...KPVLMA	579	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12011
...KPVLMA	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136816
...HVLPDL	674	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12013
...HVLPDL	674	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137931
...LDGADS	688	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2169
...LDGADS	688	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138125
...QLATDS	726	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12015
...QLATDS	726	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138676
...LDQPGG	735	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12017
...LDQPGG	735	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138806
...SPPYSS	756	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7766
...SPPYSS	756	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6321
...SPPYSS	756	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139044
...NKLTED	777	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19419
...NKLTED	777	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139282
...PGDGP	835	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PGDGP	835	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87781

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	15	ASAA.\|.ASGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	16	SAAS.\|.SGSP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	17	AASG.\|.GSPG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	17	AASG.\|.GSPG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	18	ASGS.\|.SPGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	18	ASGS.\|.SPGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	18	ASGS.\|.SPGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	18	ASGS.\|.SPGP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	49	AASS.\|.SPAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	49	AASS.\|.SPAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	57	GAEA.\|.ALEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	58	AEAL.\|.LELL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
HTRA2_HUMAN	184	QRVK.\|.KYTK	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	217	EPLV.\|.VLFC	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	316	VNDA.\|.AQKV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	410	IVAE.\|.ERPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	459	PYSS.\|.SAEP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	459	PYSS.\|.SAEP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	579	VLMA.\|.ALAE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	674	LPDL.\|.LKEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	688	GADS.\|.STGV	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> TIF1B_HUMAN @688
GRAB_HUMAN	726	ATDS.\|.STFS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	735	QPGG.\|.GTLD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	756	PYSS.\|.SPQE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	756	PYSS.\|.SPQE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	777	LTED.\|.DKAD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)