O14929: Histone acetyltransferase type B catalytic subunit

General Information

Protein names	- Histone acetyltransferase type B catalytic subunit - 2.3.1.48 {ECO:0000269\|PubMed:11585814, ECO:0000269\|PubMed:22615379, ECO:0000269\|PubMed:9427644} - Histone acetyltransferase 1
Gene names	HAT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14929

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT FFPEYTHQLF
        70         80         90        100        110        120
GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD CVEADDVEGK IRQIIPPGFC
       130        140        150        160        170        180
TNTNDFLSLL EKEVDFKPFG TLLHTYSVLS PTGGENFTFQ IYKADMTCRG FREYHERLQT
       190        200        210        220        230        240
FLMWFIETAS FIDVDDERWH YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ
       250        260        270        280        290        300
MLILTPFQGQ GHGAQLLETV HRYYTEFPTV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF
       310        320        330        340        350        360
SREKLMQGFN EDMAIEAQQK FKINKQHARR VYEILRLLVT DMSDAEQYRS YRLDIKRRLI
       370        380        390        400        410
SPYKKKQRDL AKMRKCLRPE ELTNQMNQIE ISMQHEQLEE SFQELVEDYR RVIERLAQE

Isoforms

- Isoform B of Histone acetyltransferase type B catalytic subunit

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
O14929-2-unknown	MAGFGA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14929-2-Acetylation	AGFGAM...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14929-2-Acetylation	AGFGAM...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O14929-74-unknown	ILLYYI...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18213
O14929-86-unknown	MFRVEY...	86		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76742
O14929-266-unknown	EFPTVL...	266		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5118
O14929-266-unknown	EFPTVL...	266		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145952

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YKGLKI	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18213
...HRYYTE	265	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5118
...HRYYTE	265	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129249
...RLAQE	419	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RLAQE	419	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72360

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	73	GLKI.\|.ILLY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	265	YYTE.\|.EFPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)