Q7Z7K6: Centromere protein V

General Information

Protein names	- Centromere protein V - CENP-V - Nuclear protein p30 - Proline-rich protein 6
Gene names	CENPV
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7Z7K6

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Centromere protein V - Isoform 3 of Centromere protein V

Sequence View

        10         20         30         40         50         60
MRRSRSSAAA KLRGQKRSGA SGASAAPAAS AAAALAPSAT RTRRSASQAG SKSQAVEKPP
        70         80         90        100        110        120
SEKPRLRRSS PRAQEEGPGE PPPPELALLP PPPPPPPTPA TPTSSASNLD LGEQRERWET
       130        140        150        160        170        180
FQKRQKLTSE GAAKLLLDTF EYQGLVKHTG GCHCGAVRFE VWASADLHIF DCNCSICKKK
       190        200        210        220        230        240
QNRHFIVPAS RFKLLKGAEH ITTYTFNTHK AQHTFCKRCG VQSFYTPRSN PGGFGIAPHC
       250        260        270
LDEGTVRSMV TEEFNGSDWE KAMKEHKTIK NMSKE         10         20         30         40         50         60
MRRSRSSAAA KLRGQKRSGA SGASAAPAAS AAAALAPSAT RTRRSASQAG SKSQAVEKPP
        70         80         90        100        110        120
SEKPRLRRSS PRAQEEGPGE PPPPELALLP PPPPPPPTPA TPTSSASNLD LGEQRERWET
       130        140        150        160        170        180
FQKRQKLTSE GAAKLLLDTF EYQGLVKHTG GCHCGAVRFE VWASADLHIF DCNCSICKKK
       190        200        210        220        230        240
QNRHFIVPAS RFKLLKGAEH ITTYTFNTHK AQHTFCKRCG VQSFYTPRSN PGGFGIAPHC
       250        260        270
LDEGTVRSMV TEEFNGSDWE KAMKEHKTIK NMSKE

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q7Z7K6-1-unknown	MRRSRS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q7Z7K6-1-unknown	MRRSRS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70327
Q7Z7K6-26-unknown	APAASA...	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19663
Q7Z7K6-26-unknown	APAASA...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195404
Q7Z7K6-56-unknown	VEKPPS...	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18013
Q7Z7K6-56-unknown	VEKPPS...	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139380

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SGASAA	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19663
...SKSQAV	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18013
...SKSQAV	55	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122461
...NMSKE	275	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NMSKE	275	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65944
...NMSKE	275	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65945

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	25	ASAA.\|.APAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	55	SQAV.\|.VEKP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)