O00567: Nucleolar protein 56

General Information

Protein names	- Nucleolar protein 56 - Nucleolar protein 5A
Gene names	NOP56
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00567

17 N-termini

10 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVLLHVLFEH AVGYALLALK EVEEISLLQP QVEESVLNLG KFHSIVRLVA FCPFASSQVA
        70         80         90        100        110        120
LENANAVSEG VVHEDLRLLL ETHLPSKKKK VLLGVGDPKI GAAIQEELGY NCQTGGVIAE
       130        140        150        160        170        180
ILRGVRLHFH NLVKGLTDLS ACKAQLGLGH SYSRAKVKFN VNRVDNMIIQ SISLLDQLDK
       190        200        210        220        230        240
DINTFSMRVR EWYGYHFPEL VKIINDNATY CRLAQFIGNR RELNEDKLEK LEELTMDGAK
       250        260        270        280        290        300
AKAILDASRS SMGMDISAID LINIESFSSR VVSLSEYRQS LHTYLRSKMS QVAPSLSALI
       310        320        330        340        350        360
GEAVGARLIA HAGSLTNLAK YPASTVQILG AEKALFRALK TRGNTPKYGL IFHSTFIGRA
       370        380        390        400        410        420
AAKNKGRISR YLANKCSIAS RIDCFSEVPT SVFGEKLREQ VEERLSFYET GEIPRKNLDV
       430        440        450        460        470        480
MKEAMVQAEE AAAEITRKLE KQEKKRLKKE KKRLAALALA SSENSSSTPE ECEEMSEKPK
       490        500        510        520        530        540
KKKKQKPQEV PQENGMEDPS ISFSKPKKKK SFSKEELMSS DLEETAGSTS IPKRKKSTPK
       550        560        570        580        590
EETVNDPEEA GHRSGSKKKR KFSKEEPVSS GPEEAVGKSS SKKKKKFHKA SQED

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 10 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00567-1-unknown	MVLLHV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00567-62-unknown	ENANAV...	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13698
O00567-66-	AVSEGV...	66		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00567-66-	AVSEGV...	66		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00567-66-	AVSEGV...	66		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00567-91-	VLLGVG...	91		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00567-91-	VLLGVG...	91		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O00567-425-	MVQAEE...	425		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00567-426-unknown	VQAEEA...	426	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13699
O00567-429-unknown	EEAAAE...	429	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13700
O00567-430-unknown	EAAAEI...	430	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10662
O00567-446-unknown	RLKKEK...	446	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13701
O00567-465-unknown	SSSTPE...	465	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10663
O00567-495-	GMEDPS...	495		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00567-495-	GMEDPS...	495		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00567-495-	GMEDPS...	495		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O00567-498-unknown	DPSISF...	498	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18205
O00567-511-	SFSKEE...	511		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O00567-511-	SFSKEE...	511		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O00567-519-	SSDLEE...	519		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O00567-544-unknown	VNDPEE...	544	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13702
O00567-561-	KFSKEE...	561		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O00567-562-	FSKEEP...	562		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SQVALE	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13698
...SRSSMG	252	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388497
...MKEAMV	425	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13699
...AMVQAE	428	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13700
...MVQAEE	429	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10662
...KQEKKR	445	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13701
...ASSENS	464	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10663
...ENGMED	497	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18205
...PKEETV	543	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13702
...ASQED	594	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	61	VALE.\|.ENAN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	425	EAMV.\|.VQAE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	428	VQAE.\|.EEAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	429	QAEE.\|.EAAA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	445	EKKR.\|.RLKK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	464	SENS.\|.SSST	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	497	GMED.\|.DPSI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	543	EETV.\|.VNDP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)