P46777: 60S ribosomal protein L5

General Information

Protein names	- 60S ribosomal protein L5 - Large ribosomal subunit protein uL18 {ECO:0000303\|PubMed:24524803}
Gene names	RPL5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P46777

22 N-termini

12 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGFVKVVKNK AYFKRYQVKF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI
        70         80         90        100        110        120
ICQIAYARIE GDMIVCAAYA HELPKYGVKV GLTNYAAAYC TGLLLARRLL NRFGMDKIYE
       130        140        150        160        170        180
GQVEVTGDEY NVESIDGQPG AFTCYLDAGL ARTTTGNKVF GALKGAVDGG LSIPHSTKRF
       190        200        210        220        230        240
PGYDSESKEF NAEVHRKHIM GQNVADYMRY LMEEDEDAYK KQFSQYIKNS VTPDMMEEMY
       250        260        270        280        290
KKAHAAIREN PVYEKKPKKE VKKKRWNRPK MSLAQKKDRV AQKKASFLRA QERAAES

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

22 N-termini - 12 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P46777-2-unknown	MGFVKV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46777-2-unknown	MGFVKV...	1			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P46777-2-unknown	MGFVKV...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P46777-2-unknown	MGFVKV...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P46777-2-unknown	MGFVKV...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P46777-2-	GFVKVV...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46777-2-	GFVKVV...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P46777-2-	GFVKVV...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P46777-2-Acetylation	GFVKVV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46777-18-unknown	VKFRRR...	18		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P46777-24-unknown	REGKTD...	24		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P46777-36-	LVIQDK...	36			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P46777-41-unknown	KNKYNT...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11538
P46777-42-unknown	NKYNTP...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10089
P46777-49-unknown	YRMIVR...	49		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P46777-51-unknown	MIVRVT...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000359338
P46777-77-unknown	AAYAHE...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7475
P46777-129-unknown	EYNVES...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11539
P46777-159-unknown	VFGALK...	159		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10090
P46777-165-unknown	GAVDGG...	165		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5887
P46777-169-	GGLSIP...	169			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P46777-169-	GGLSIP...	169			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46777-169-	GGLSIP...	169			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P46777-184-unknown	DSESKE...	184		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19122
P46777-184-unknown	DSESKE...	184		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17663
P46777-200-	MGQNVA...	200			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P46777-200-	MGQNVA...	200			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P46777-200-unknown	MGQNVA...	200			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P46777-213-unknown	EEDEDA...	213		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7476
P46777-214-unknown	EDEDAY...	214		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7477
P46777-230-	SVTPDM...	230			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P46777-289-unknown	RAQERA...	289		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14135

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LVIQDK	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11538
...VIQDKN	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10089
...DMIVCA	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7475
...EVTGDE	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11539
...TTGNKV	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10090
...FGALKG	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5887
...STKRFP	180	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000359338
...RFPGYD	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19122
...RFPGYD	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17663
...MRYLME	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7476
...RYLMEE	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7477
...KASFLR	288	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14135
...RAAES	297	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	40	IQDK.\|.KNKY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	41	QDKN.\|.NKYN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATS_HUMAN	76	IVCA.\|.AAYA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	128	TGDE.\|.EYNV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	158	GNKV.\|.VFGA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	164	ALKG.\|.GAVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	183	PGYD.\|.DSES	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	183	PGYD.\|.DSES	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	212	YLME.\|.EEDE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	213	LMEE.\|.EDED	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	288	SFLR.\|.RAQE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)