Q9BWD1: Acetyl-CoA acetyltransferase, cytosolic

General Information

Protein names	- Acetyl-CoA acetyltransferase, cytosolic - 2.3.1.9 {ECO:0000255\|PROSITE-ProRule:PRU10020, ECO:0000269\|PubMed:7911016} - Acetyl-CoA transferase-like protein - Cytosolic acetoacetyl-CoA thiolase
Gene names	ACAT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BWD1

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNAGSDPVVI VSAARTIIGS FNGALAAVPV QDLGSTVIKE VLKRATVAPE DVSEVIFGHV
        70         80         90        100        110        120
LAAGCGQNPV RQASVGAGIP YSVPAWSCQM ICGSGLKAVC LAVQSIGIGD SSIVVAGGME
       130        140        150        160        170        180
NMSKAPHLAY LRTGVKIGEM PLTDSILCDG LTDAFHNCHM GITAENVAKK WQVSREDQDK
       190        200        210        220        230        240
VAVLSQNRTE NAQKAGHFDK EIVPVLVSTR KGLIEVKTDE FPRHGSNIEA MSKLKPYFLT
       250        260        270        280        290        300
DGTGTVTPAN ASGINDGAAA VVLMKKSEAD KRGLTPLARI VSWSQVGVEP SIMGIGPIPA
       310        320        330        340        350        360
IKQAVTKAGW SLEDVDIFEI NEAFAAVSAA IVKELGLNPE KVNIEGGAIA LGHPLGASGC
       370        380        390
RILVTLLHTL ERMGRSRGVA ALCIGGGMGI AMCVQRE

Isoforms

- Isoform 2 of Acetyl-CoA acetyltransferase, cytosolic

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BWD1-1-acetylation,unknown	MNAGSD...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BWD1-1-Acetylation	MNAGSD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BWD1-1-Acetylation	MNAGSD...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9BWD1-1-Acetylation	MNAGSD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BWD1-1-Acetylation	MNAGSD...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9BWD1-3-	AGSDPV...	3			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9BWD1-5-	SDPVVI...	5			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9BWD1-62-unknown	AAGCGQ...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4240
Q9BWD1-256-unknown	DGAAAV...	256		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19779

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FGHVLA	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4240
...ASGIND	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19779
...CVQRE	397	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	61	HVLA.\|.AAGC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	255	GIND.\|.DGAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)