P63104: 14-3-3 protein zeta/delta

General Information

Protein names	- 14-3-3 protein zeta/delta - Protein kinase C inhibitor protein 1 - KCIP-1
Gene names	YWHAZ
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P63104

15 N-termini

8 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR
        70         80         90        100        110        120
VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QAESKVFYLK
       130        140        150        160        170        180
MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE
       190        200        210        220        230        240
ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG

EGGEN

Isoforms

- Isoform 2 of 14-3-3 protein zeta/delta

Sequence View

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Protein Neighborhood

Domains & Features

15 N-termini - 8 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63104-1-Acetylation	MDKNEL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63104-1-Acetylation	MDKNEL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P63104-1-Acetylation	MDKNEL...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P63104-1-Acetylation	MDKNEL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P63104-1-Acetylation	MDKNEL...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P63104-2-unknown	DKNELV...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P63104-28-	SVTEQG...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P63104-28-	SVTEQG...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63104-28-	SVTEQG...	28			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P63104-28-	SVTEQG...	28			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P63104-28-	SVTEQG...	28			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P63104-28-	SVTEQG...	28			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P63104-28-	SVTEQG...	28			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P63104-31-unknown	EQGAEL...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6145
P63104-145-unknown	SQQAYQ...	145		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166824
P63104-145-	SQQAYQ...	145			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P63104-145-	SQQAYQ...	145			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63104-145-	SQQAYQ...	145			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P63104-145-	SQQAYQ...	145			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P63104-145-	SQQAYQ...	145			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P63104-148-	AYQEAF...	148			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63104-148-unknown	AYQEAF...	148		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173178
P63104-149-unknown	YQEAFE...	149		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19274
P63104-149-unknown	YQEAFE...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140881
P63104-151-unknown	EAFEIS...	151		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6146
P63104-151-unknown	EAFEIS...	151		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141004
P63104-199-unknown	AIAELD...	199		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170453
P63104-199-	AIAELD...	199			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63104-199-	AIAELD...	199			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P63104-205-unknown	TLSEES...	205		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2610
P63104-205-unknown	TLSEES...	205		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143886
P63104-208-unknown	EESYKD...	208		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19276
P63104-208-unknown	EESYKD...	208		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143999
P63104-236-unknown	EAEAGE...	236		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2612
P63104-236-unknown	EAEAGE...	236		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145176

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MKSVTE	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6145
...QSQQAY	148	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19274
...QSQQAY	148	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124022
...QQAYQE	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6146
...QQAYQE	150	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124154
...IAELDT	204	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2610
...IAELDT	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127130
...LDTLSE	207	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19276
...LDTLSE	207	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127242
...DTQGDE	235	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2612
...DTQGDE	235	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128464
...EGGEN	245	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EGGEN	245	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt61341
...EGGEN	245		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EGGEN	245		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	30	SVTE.\|.EQGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	148	QQAY.\|.YQEA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	150	AYQE.\|.EAFE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP6_HUMAN	204	ELDT.\|.TLSE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
MEP1B_HUMAN	207	TLSE.\|.EESY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP6_HUMAN	235	QGDE.\|.EAEA	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)