Q14257: Reticulocalbin-2

General Information

Protein names	- Reticulocalbin-2 - Calcium-binding protein ERC-55 - E6-binding protein - E6BP
Gene names	RCN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14257

5 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQED VDEYVKLGHE
        70         80         90        100        110        120
EQQKRLQAII KKIDLDSDGF LTESELSSWI QMSFKHYAMQ EAKQQFVEYD KNSDDTVTWD
       130        140        150        160        170        180
EYNIQMYDRV IDFDENTALD DAEEESFRKL HLKDKKRFEK ANQDSGPGLS LEEFIAFEHP
       190        200        210        220        230        240
EEVDYMTEFV IQEALEEHDK NGDGFVSLEE FLGDYRWDPT ANEDPEWILV EKDRFVNDYD
       250        260        270        280        290        300
KDNDGRLDPQ ELLPWVVPNN QGIAQEEALH LIDEMDLNGD KKLSEEEILE NPDLFLTSEA
       310
TDYGRQLHDD YFYHDEL

Isoforms

- Isoform 2 of Reticulocalbin-2

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14257-23-unknown	GKAEEL...	23	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14257-23-unknown	GKAEEL...	23	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q14257-23-unknown	GKAEEL...	23		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14257-23-unknown	GKAEEL...	23		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14257-23-	GKAEEL...	23		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14257-46-	GVQEDV...	46		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14257-46-	GVQEDV...	46		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14257-46-	GVQEDV...	46		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14257-50-unknown	DVDEYV...	50	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17938
Q14257-50-unknown	DVDEYV...	50	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19514
Q14257-204-	GFVSLE...	204		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGVQED	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17938
...LGVQED	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19514
...YHDEL	317	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	49	VQED.\|.DVDE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	49	VQED.\|.DVDE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)