Q15653: NF-kappa-B inhibitor beta

General Information

Protein names	- NF-kappa-B inhibitor beta - NF-kappa-BIB - I-kappa-B-beta - IkB-B - IkB-beta - IkappaBbeta - Thyroid receptor-interacting protein 9 - TR-interacting protein 9 - TRIP-9
Gene names	NFKBIB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15653

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGVACLGKA ADADEWCDSG LGSLGPDAAA PGGPGLGAEL GPGLSWAPLV FGYVTEDGDT
        70         80         90        100        110        120
ALHLAVIHQH EPFLDFLLGF SAGTEYMDLQ NDLGQTALHL AAILGETSTV EKLYAAGAGL
       130        140        150        160        170        180
CVAERRGHTA LHLACRVGAH ACARALLQPR PRRPREAPDT YLAQGPDRTP DTNHTPVALY
       190        200        210        220        230        240
PDSDLEKEEE ESEEDWKLQL EAENYEGHTP LHVAVIHKDV EMVRLLRDAG ADLDKPEPTC
       250        260        270        280        290        300
GRSPLHLAVE AQAADVLELL LRAGANPAAR MYGGRTPLGS AMLRPNPILA RLLRAHGAPE
       310        320        330        340        350
PEGEDEKSGP CSSSSDSDSG DEGDEYDDIV VHSSRSQTRL PPTPASKPLP DDPRPV

Isoforms

- Isoform 2 of NF-kappa-B inhibitor beta

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15653-1-unknown	MAGVAC...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15653-1-unknown	MAGVAC...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77670
Q15653-156-unknown	EAPDTY...	156	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19585
Q15653-156-unknown	EAPDTY...	156	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144991
Q15653-160-unknown	TYLAQG...	160	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164816
Q15653-160-	TYLAQG...	160		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q15653-160-	TYLAQG...	160		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15653-160-	TYLAQG...	160		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRRPRE	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19585
...PRRPRE	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128271
...DPRPV	356	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	155	RPRE.\|.EAPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)