O00625: Pirin

General Information

Protein names	- Pirin - 1.13.11.24 - Probable quercetin 2,3-dioxygenase PIR - Probable quercetinase
Gene names	PIR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00625

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGSSKKVTLS VLSREQSEGV GARVRRSIGR PELKNLDPFL LFDEFKGGRP GGFPDHPHRG
        70         80         90        100        110        120
FETVSYLLEG GSMAHEDFCG HTGKMNPGDL QWMTAGRGIL HAEMPCSEEP AHGLQLWVNL
       130        140        150        160        170        180
RSSEKMVEPQ YQELKSEEIP KPSKDGVTVA VISGEALGIK SKVYTRTPTL YLDFKLDPGA
       190        200        210        220        230        240
KHSQPIPKGW TSFIYTISGD VYIGPDDAQQ KIEPHHTAVL GEGDSVQVEN KDPKRSHFVL
       250        260        270        280        290
IAGEPLREPV IQHGPFVMNT NEEISQAILD FRNAKNGFER AKTWKSKIGN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00625-1-unknown	MGSSKK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00625-2-acetylation	GSSKKV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O00625-2-acetylation	GSSKKV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O00625-224-unknown	DSVQVE...	224		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18206
O00625-224-unknown	DSVQVE...	224		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16863

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VLGEGD	223	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18206
...VLGEGD	223	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16863
...SKIGN	290		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SKIGN	290	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SKIGN	290		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	223	GEGD.\|.DSVQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	223	GEGD.\|.DSVQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)