P08133: Annexin A6

General Information

Protein names	- Annexin A6 - 67 kDa calelectrin - Annexin VI - Annexin-6 - Calphobindin-II - CPB-II - Chromobindin-20 - Lipocortin VI - Protein III - p68 - p70
Gene names	ANXA6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08133

14 N-termini

10 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR SNRQRQEVCQ
        70         80         90        100        110        120
SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE IKDAISGIGT DEKCLIEILA
       130        140        150        160        170        180
SRTNEQMHQL VAAYKDAYER DLEADIIGDT SGHFQKMLVV LLQGTREEDD VVSEDLVQQD
       190        200        210        220        230        240
VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK
       250        260        270        280        290        300
LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
       310        320        330        340        350        360
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR VELKGTVRPA
       370        380        390        400        410        420
NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ IRQTFKSHFG RDLMTDLKSE
       430        440        450        460        470        480
ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKALIE ILATRTNAEI RAINEAYKED
       490        500        510        520        530        540
YHKSLEDALS SDTSGHFRRI LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK
       550        560        570        580        590        600
TSLETRFMTI LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK
       610        620        630        640        650        660
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD
       670
FLKALLALCG GED

Isoforms

- Isoform 2 of Annexin A6

Sequence View

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Protein Neighborhood

Domains & Features

14 N-termini - 10 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08133-2-unknown	MAKPAQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08133-2-Acetylation	AKPAQG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08133-2-Acetylation	AKPAQG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P08133-2-Acetylation	AKPAQG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P08133-2-Acetylation	AKPAQG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P08133-33-unknown	MKGFGS...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67108
P08133-125-unknown	EQMHQL...	125		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18594
P08133-125-unknown	EQMHQL...	125		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142030
P08133-149-unknown	DTSGHF...	149		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7245
P08133-149-unknown	DTSGHF...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143319
P08133-378-	GLGTDE...	378			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08133-378-	GLGTDE...	378			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08133-378-	GLGTDE...	378			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P08133-378-unknown	GLGTDE...	378		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168056
P08133-385-unknown	TIIDII...	385		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17218
P08133-385-unknown	TIIDII...	385		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151004
P08133-491-unknown	SDTSGH...	491		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7247
P08133-491-unknown	SDTSGH...	491		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5491
P08133-491-unknown	SDTSGH...	491		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152896
P08133-504-unknown	LATGHR...	504		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3536
P08133-504-unknown	LATGHR...	504		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153106
P08133-505-unknown	ATGHRE...	505		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3538
P08133-505-unknown	ATGHRE...	505		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153113
P08133-506-unknown	TGHREE...	506		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5493
P08133-506-unknown	TGHREE...	506		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153117
P08133-507-unknown	GHREEG...	507		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5495
P08133-507-unknown	GHREEG...	507		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153136
P08133-651-unknown	QAIEGD...	651		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7249
P08133-651-unknown	QAIEGD...	651		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5497
P08133-651-unknown	QAIEGD...	651		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154896

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASRTNE	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18594
...ASRTNE	124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125211
...ADIIGD	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7245
...ADIIGD	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126550
...GTDEDT	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17218
...GTDEDT	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134407
...EDALSS	490	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7247
...EDALSS	490	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5491
...EDALSS	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136321
...RILISL	503	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3536
...RILISL	503	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136531
...ILISLA	504	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3538
...ILISLA	504	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136538
...LISLAT	505	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5493
...LISLAT	505	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136542
...ISLATG	506	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5495
...ISLATG	506	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136561
...DKSLHQ	650	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7249
...DKSLHQ	650	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5497
...DKSLHQ	650	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138323
...CGGED	673	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CGGED	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62726

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	124	RTNE.\|.EQMH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	148	IIGD.\|.DTSG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	384	DEDT.\|.TIID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	490	ALSS.\|.SDTS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	490	ALSS.\|.SDTS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	503	LISL.\|.LATG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	504	ISLA.\|.ATGH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	505	SLAT.\|.TGHR	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	506	LATG.\|.GHRE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	650	SLHQ.\|.QAIE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	650	SLHQ.\|.QAIE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)