Q14978: Nucleolar and coiled-body phosphoprotein 1 {ECO:0000305}

General Information

Protein names	- Nucleolar and coiled-body phosphoprotein 1 {ECO:0000305} - 140 kDa nucleolar phosphoprotein {ECO:0000303\|PubMed:10567578} - Nopp140 {ECO:0000303\|PubMed:10567578} - Hepatitis C virus NS5A-transactivated protein 13 - HCV NS5A-transactivated protein 13 - Nucleolar 130 kDa protein {ECO:0000303\|PubMed:7657714} - Nucleolar phosphoprotein p130 {ECO:0000303\|PubMed:7657714}
Gene names	NOLC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14978

26 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Beta of Nucleolar and coiled-body phosphoprotein 1 - Isoform 3 of Nucleolar and coiled-body phosphoprotein 1

Sequence View

        10         20         30         40         50         60
MADAGIRRVV PSDLYPLVLG FLRDNQLSEV ANKFAKATGA TQQDANASSL LDIYSFWLKS
        70         80         90        100        110        120
AKVPERKLQA NGPVAKKAKK KASSSDSEDS SEEEEEVQGP PAKKAAVPAK RVGLPPGKAA
       130        140        150        160        170        180
AKASESSSSE ESSDDDDEED QKKQPVQKGV KPQAKAAKAP PKKAKSSDSD SDSSSEDEPP
       190        200        210        220        230        240
KNQKPKITPV TVKAQTKAPP KPARAAPKIA NGKAASSSSS SSSSSSSDDS EEEKAAATPK
       250        260        270        280        290        300
KTVPKKQVVA KAPVKAATTP TRKSSSSEDS SSDEEEEQKK PMKNKPGPYS SVPPPSAPPP
       310        320        330        340        350        360
KKSLGTQPPK KAVEKQQPVE SSEDSSDESD SSSEEEKKPP TKAVVSKATT KPPPAKKAAE
       370        380        390        400        410        420
SSSDSSDSDS SEDDEAPSKP AGTTKNSSNK PAVTTKSPAV KPAAAPKQPV GGGQKLLTRK
       430        440        450        460        470        480
ADSSSSEEES SSSEEEKTKK MVATTKPKAT AKAALSLPAK QAPQGSRDSS SDSDSSSSEE
       490        500        510        520        530        540
EEEKTSKSAV KKKPQKVAGG AAPSKPASAK KGKAESSNSS SSDDSSEEEE EKLKGKGSPR
       550        560        570        580        590        600
PQAPKANGTS ALTAQNGKAA KNSEEEEEEK KKAAVVVSKS GSLKKRKQNE AAKEAETPQA
       610        620        630        640        650        660
KKIKLQTPNT FPKRKKGEKR ASSPFRRVRE EEIEVDSRVA DNSFDAKRGA AGDWGERANQ
       670        680        690
VLKFTKGKSF RHEKTKKKRG SYRGGSISVQ VNSIKFDSE         10         20         30         40         50         60
MADAGIRRVV PSDLYPLVLG FLRDNQLSEV ANKFAKATGA TQQDANASSL LDIYSFWLKS
        70         80         90        100        110        120
AKVPERKLQA NGPVAKKAKK KASSSDSEDS SEEEEEVQGP PAKKAAVPAK RVGLPPGKAA
       130        140        150        160        170        180
AKASESSSSE ESSDDDDEED QKKQPVQKGV KPQAKAAKAP PKKAKSSDSD SDSSSEDEPP
       190        200        210        220        230        240
KNQKPKITPV TVKAQTKAPP KPARAAPKIA NGKAASSSSS SSSSSSSDDS EEEKAAATPK
       250        260        270        280        290        300
KTVPKKQVVA KAPVKAATTP TRKSSSSEDS SSDEEEEQKK PMKNKPGPYS SVPPPSAPPP
       310        320        330        340        350        360
KKSLGTQPPK KAVEKQQPVE SSEDSSDESD SSSEEEKKPP TKAVVSKATT KPPPAKKAAE
       370        380        390        400        410        420
SSSDSSDSDS SEDDEAPSKP AGTTKNSSNK PAVTTKSPAV KPAAAPKQPV GGGQKLLTRK
       430        440        450        460        470        480
ADSSSSEEES SSSEEEKTKK MVATTKPKAT AKAALSLPAK QAPQGSRDSS SDSDSSSSEE
       490        500        510        520        530        540
EEEKTSKSAV KKKPQKVAGG AAPSKPASAK KGKAESSNSS SSDDSSEEEE EKLKGKGSPR
       550        560        570        580        590        600
PQAPKANGTS ALTAQNGKAA KNSEEEEEEK KKAAVVVSKS GSLKKRKQNE AAKEAETPQA
       610        620        630        640        650        660
KKIKLQTPNT FPKRKKGEKR ASSPFRRVRE EEIEVDSRVA DNSFDAKRGA AGDWGERANQ
       670        680        690
VLKFTKGKSF RHEKTKKKRG SYRGGSISVQ VNSIKFDSE

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

26 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14978-1-unknown	MADAGI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14978-1-unknown	MADAGI...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83032
Q14978-1-unknown	MADAGI...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83033
Q14978-139-unknown	EDQKKQ...	139	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19536
Q14978-139-unknown	EDQKKQ...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144248
Q14978-139-unknown	EDQKKQ...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144297
Q14978-197-	KAPPKP...	197		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14978-197-unknown	KAPPKP...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178528
Q14978-197-unknown	KAPPKP...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178527
Q14978-290-	SSVPPP...	290		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14978-290-unknown	SSVPPP...	290		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14978-290-unknown	SSVPPP...	290	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159988
Q14978-290-unknown	SSVPPP...	290	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159989
Q14978-303-unknown	SLGTQP...	303	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172274
Q14978-303-unknown	SLGTQP...	303	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172275
Q14978-303-	SLGTQP...	303		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14978-375-unknown	EAPSKP...	375	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19539
Q14978-375-unknown	EAPSKP...	375	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151535
Q14978-375-unknown	EAPSKP...	375	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151736
Q14978-387-unknown	SSNKPA...	387	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171439
Q14978-387-unknown	SSNKPA...	387	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171440
Q14978-387-	SSNKPA...	387		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14978-392-unknown	AVTTKS...	392	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172271
Q14978-392-unknown	AVTTKS...	392	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172272
Q14978-392-	AVTTKS...	392		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14978-393-unknown	VTTKSP...	393	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172277
Q14978-393-unknown	VTTKSP...	393	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172278
Q14978-393-	VTTKSP...	393		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14978-399-unknown	AVKPAA...	399	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172268
Q14978-399-unknown	AVKPAA...	399	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172269
Q14978-399-	AVKPAA...	399		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14978-453-	AALSLP...	453		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q14978-453-unknown	AALSLP...	453	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164957
Q14978-453-unknown	AALSLP...	453	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164958
Q14978-456-unknown	SLPAKQ...	456	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14511
Q14978-456-unknown	SLPAKQ...	456	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152874
Q14978-456-unknown	SLPAKQ...	456	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153017
Q14978-497-unknown	VAGGAA...	497	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174484
Q14978-497-unknown	VAGGAA...	497	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174485
Q14978-497-	VAGGAA...	497		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14978-497-	VAGGAA...	497		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q14978-500-unknown	GAAPSK...	500	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6413
Q14978-500-unknown	GAAPSK...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153417
Q14978-500-unknown	GAAPSK...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153534
Q14978-580-unknown	SGSLKK...	580	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10300
Q14978-580-unknown	SGSLKK...	580	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154338
Q14978-580-unknown	SGSLKK...	580	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154458
Q14978-630-unknown	EEEIEV...	630	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10303
Q14978-630-unknown	EEEIEV...	630	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155064
Q14978-630-unknown	EEEIEV...	630	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155201
Q14978-648-unknown	RGAAGD...	648	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12298
Q14978-648-unknown	RGAAGD...	648	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155288
Q14978-648-unknown	RGAAGD...	648	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155404

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDDDEE	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19536
...DDDDEE	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127503
...DDDDEE	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127556
...SSEDDE	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19539
...SSEDDE	374	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134940
...SSEDDE	374	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135141
...AKAALS	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14511
...AKAALS	455	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136299
...AKAALS	455	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136443
...QKVAGG	499	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6413
...QKVAGG	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136840
...QKVAGG	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136956
...VVVSKS	579	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10300
...VVVSKS	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137759
...VVVSKS	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137879
...FRRVRE	629	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10303
...FRRVRE	629	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138491
...FRRVRE	629	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138632
...SFDAKR	647	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12298
...SFDAKR	647	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138721
...SFDAKR	647	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138839
...KFDSE	699	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KFDSE	699	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78651
...KFDSE	699	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78650

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	138	DDEE.\|.EDQK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	374	EDDE.\|.EAPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	455	AALS.\|.SLPA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	499	VAGG.\|.GAAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	579	VSKS.\|.SGSL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	629	RVRE.\|.EEEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	647	DAKR.\|.RGAA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)