Q10713: Mitochondrial-processing peptidase subunit alpha

General Information

Protein names	- Mitochondrial-processing peptidase subunit alpha - Alpha-MPP - P-55
Gene names	PMPCA
Organism	Homo sapiens
Protease Family
Protease ID	M16.P01
Chromosome location
UniProt ID	Q10713

6 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAVVLAATR LLRGSGSWGC SRLRFGPPAY RRFSSGGAYP NIPLSSPLPG VPKPVFATVD
        70         80         90        100        110        120
GQEKFETKVT TLDNGLRVAS QNKFGQFCTV GILINSGSRY EAKYLSGIAH FLEKLAFSST
       130        140        150        160        170        180
ARFDSKDEIL LTLEKHGGIC DCQTSRDTTM YAVSADSKGL DTVVALLADV VLQPRLTDEE
       190        200        210        220        230        240
VEMTRMAVQF ELEDLNLRPD PEPLLTEMIH EAAYRENTVG LHRFCPTENV AKINREVLHS
       250        260        270        280        290        300
YLRNYYTPDR MVLAGVGVEH EHLVDCARKY LLGVQPAWGS AEAVDIDRSV AQYTGGIAKL
       310        320        330        340        350        360
ERDMSNVSLG PTPIPELTHI MVGLESCSFL EEDFIPFAVL NMMMGGGGSF SAGGPGKGMF
       370        380        390        400        410        420
SRLYLNVLNR HHWMYNATSY HHSYEDTGLL CIHASADPRQ VREMVEIITK EFILMGGTVD
       430        440        450        460        470        480
TVELERAKTQ LTSMLMMNLE SRPVIFEDVG RQVLATRSRK LPHELCTLIR NVKPEDVKRV
       490        500        510        520
ASKMLRGKPA VAALGDLTDL PTYEHIQTAL SSKDGRLPRT YRLFR

Isoforms

- Isoform 2 of Mitochondrial-processing peptidase subunit alpha

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q10713-34-unknown	SSGGAY...	34	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q10713-34-	SSGGAY...	34		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q10713-46-unknown	SPLPGV...	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6253
Q10713-293-unknown	YTGGIA...	293	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408393
Q10713-293-unknown	YTGGIA...	293	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130535
Q10713-346-unknown	GGGSFS...	346	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3970
Q10713-346-unknown	GGGSFS...	346	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147174
Q10713-504-unknown	EHIQTA...	504	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19385
Q10713-504-unknown	EHIQTA...	504	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151463

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NIPLSS	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6253
...CQTSRD	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000360785
...NMMMGG	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3970
...NMMMGG	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130512
...DLPTYE	503	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19385
...DLPTYE	503	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134868
...YRLFR	525	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YRLFR	525	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77101

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	45	PLSS.\|.SPLP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	345	MMGG.\|.GGGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	503	PTYE.\|.EHIQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)