O00487: 26S proteasome non-ATPase regulatory subunit 14

General Information

Protein names	- 26S proteasome non-ATPase regulatory subunit 14 - 3.4.19.- - 26S proteasome regulatory subunit RPN11 - 26S proteasome-associated PAD1 homolog 1
Gene names	PSMD14
Organism	Homo sapiens
Protease Family
Protease ID	M67.001
Chromosome location
UniProt ID	O00487

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDRLLRLGGG MPGLGQGPPT DAPAVDTAEQ VYISSLALLK MLKHGRAGVP MEVMGLMLGE
        70         80         90        100        110        120
FVDDYTVRVI DVFAMPQSGT GVSVEAVDPV FQAKMLDMLK QTGRPEMVVG WYHSHPGFGC
       130        140        150        160        170        180
WLSGVDINTQ QSFEALSERA VAVVVDPIQS VKGKVVIDAF RLINANMMVL GHEPRQTTSN
       190        200        210        220        230        240
LGHLNKPSIQ ALIHGLNRHY YSITINYRKN ELEQKMLLNL HKKSWMEGLT LQDYSEHCKH
       250        260        270        280        290        300
NESVVKEMLE LAKNYNKAVE EEDKMTPEQL AIKNVGKQDP KRHLEEHVDV LMTSNIVQCL
       310
AAMLDTVVFK

Isoforms

Sequence View

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Evidence Codes:

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00487-1-unknown	MDRLLR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00487-167-	MMVLGH...	167		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00487-263-unknown	DKMTPE...	263	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18203

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TGVSVE	84	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399311
...AVEEED	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18203
...TVVFK	310	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	262	EEED.\|.DKMT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)