P07476: Involucrin

General Information

Protein names	- Involucrin
Gene names	IVL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07476

5 N-termini

4 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE LPVEVPSKQE
        70         80         90        100        110        120
EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK AENPEQQLKQ EKTQRDQQLN
       130        140        150        160        170        180
KQLEEEKKLL DQQLDQELVK RDEQLGMKKE QLLELPEQQE GHLKHLEQQE GQLKHPEQQE
       190        200        210        220        230        240
GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE
       250        260        270        280        290        300
GQLELSEQQE GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE
       310        320        330        340        350        360
KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE GQLEHLEHQE
       370        380        390        400        410        420
GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE GQLKHLVQQE GQLEQQERQV
       430        440        450        460        470        480
EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV
       490        500        510        520        530        540
KHLEKQEAQL ELPEQQVGQP KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL
       550        560        570        580
EQPVFAPAPG QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P07476-1-unknown	MSQQHT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07476-96-unknown	EEYQKA...	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17161
P07476-96-unknown	EEYQKA...	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18547
P07476-97-unknown	EYQKAE...	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18548
P07476-103-unknown	NPEQQL...	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17162
P07476-103-unknown	NPEQQL...	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18549
P07476-147-unknown	MKKEQL...	147	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000376435

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HWEQHE	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17161
...HWEQHE	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18547
...WEQHEE	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18548
...YQKAEN	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17162
...YQKAEN	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18549
...PPKHK	585	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	95	EQHE.\|.EEYQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	95	EQHE.\|.EEYQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	96	QHEE.\|.EYQK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	102	KAEN.\|.NPEQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	102	KAEN.\|.NPEQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)