P05455: Lupus La protein

General Information

Protein names	- Lupus La protein - La autoantigen - La ribonucleoprotein - Sjoegren syndrome type B antigen - SS-B
Gene names	SSB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05455

9 N-termini

10 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE IMIKFNRLNR
        70         80         90        100        110        120
LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV TDEYKNDVKN RSVYIKGFPT
       130        140        150        160        170        180
DATLDDIKEW LEDKGQVLNI QMRRTLHKAF KGSIFVVFDS IESAKKFVET PGQKYKETDL
       190        200        210        220        230        240
LILFKDDYFA KKNEERKQNK VEAKLRAKQE QEAKQKLEED AEMKSLEEKI GCLLKFSGDL
       250        260        270        280        290        300
DDQTCREDLH ILFSNHGEIK WIDFVRGAKE GIILFKEKAK EALGKAKDAN NGNLQLRNKE
       310        320        330        340        350        360
VTWEVLEGEV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQPGS GKGKVQFQGK
       370        380        390        400
KTKFASDDEH DEHDENGATG PVKRAREETD KEEPASKQQK TENGAGDQ

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 10 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05455-1-unknown	MAENGD...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05455-52-unknown	MIKFNR...	52	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396890
P05455-79-unknown	LMEISE...	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17119
P05455-221-unknown	AEMKSL...	221	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11048
P05455-254-unknown	SNHGEI...	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18483
P05455-345-unknown	AAQPGS...	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13916
P05455-365-unknown	ASDDEH...	365	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13664
P05455-372-unknown	EHDENG...	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1564
P05455-375-unknown	ENGATG...	375	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1565

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KSKAEL	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17119
...FVETPG	171	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396890
...LLILFK	184	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397029
...KLEEDA	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11048
...LHILFS	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18483
...GKGNKA	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13916
...KKTKFA	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13664
...DDEHDE	371	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1564
...HDEHDE	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1565
...GAGDQ	408	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	78	KAEL.\|.LMEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	220	EEDA.\|.AEMK	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,
MEP1B_HUMAN	253	ILFS.\|.SNHG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	344	GNKA.\|.AAQP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAH_HUMAN	364	TKFA.\|.ASDD	inferred from experiment	unknown	MEROPS	Andrade F	Romero V et al.:Cleavage of La protein by granz... (S01.147)	19039329,
CASP3_HUMAN	371	EHDE.\|.EHDE	inferred from experiment	unknown	MEROPS	Liu R	Ju W et al.:Proteome-wide identification of... (C14.003)	17728405,
CASP3_HUMAN	374	EHDE.\|.ENGA	inferred from experiment	unknown	MEROPS	Liu R	Ju W et al.:Proteome-wide identification of... (C14.003)	17728405,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)