TopFIND 4.0

P20718: Granzyme H

General Information

Protein names
- Granzyme H
- 3.4.21.-
- CCP-X
- Cathepsin G-like 2
- CTSGL2
- Cytotoxic T-lymphocyte proteinase
- Cytotoxic serine protease C
- CSP-C
Gene names GZMH
Organism Homo sapiens
Protease Family S01.147
Protease ID S01.147
Chromosome location
UniProt ID P20718

2

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MQPFLLLLAF LLTPGAGTEE IIGGHEAKPH SRPYMAFVQF LQEKSRKRCG GILVRKDFVL 
        70         80         90        100        110        120 
TAAHCQGSSI NVTLGAHNIK EQERTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKW 
       130        140        150        160        170        180 
TTAVRPLRLP SSKAQVKPGQ LCSVAGWGYV SMSTLATTLQ EVLLTVQKDC QCERLFHGNY 
       190        200        210        220        230        240 
SRATEICVGD PKKTQTGFKG DSGGPLVCKD VAQGILSYGN KKGTPPGVYI KVSHFLPWIK 
   
RTMKRL

Isoforms

- Isoform 2 of Granzyme H - Isoform 3 of Granzyme H

Sequence View

        10         20         30         40         50         60 
MQPFLLLLAF LLTPGAGTEE IIGGHEAKPH SRPYMAFVQF LQEKSRKRCG GILVRKDFVL 
        70         80         90        100        110        120 
TAAHCQGSSI NVTLGAHNIK EQERTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKW 
       130        140        150        160        170        180 
TTAVRPLRLP SSKAQVKPGQ LCSVAGWGYV SMSTLATTLQ EVLLTVQKDC QCERLFHGNY 
       190        200        210        220        230        240 
SRATEICVGD PKKTQTGFKG DSGGPLVCKD VAQGILSYGN KKGTPPGVYI KVSHFLPWIK 
   
RTMKRL         10         20         30         40         50         60 
MQPFLLLLAF LLTPGAGTEE IIGGHEAKPH SRPYMAFVQF LQEKSRKRCG GILVRKDFVL 
        70         80         90        100        110        120 
TAAHCQGSSI NVTLGAHNIK EQERTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKW 
       130        140        150        160        170        180 
TTAVRPLRLP SSKAQVKPGQ LCSVAGWGYV SMSTLATTLQ EVLLTVQKDC QCERLFHGNY 
       190        200        210        220        230        240 
SRATEICVGD PKKTQTGFKG DSGGPLVCKD VAQGILSYGN KKGTPPGVYI KVSHFLPWIK 
   
RTMKRL



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates