Q13561: Dynactin subunit 2

General Information

Protein names	- Dynactin subunit 2 - 50 kDa dynein-associated polypeptide - Dynactin complex 50 kDa subunit - DCTN-50 - p50 dynamitin
Gene names	DCTN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13561

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Dynactin subunit 2 - Isoform 3 of Dynactin subunit 2

Sequence View

        10         20         30         40         50         60
MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP NAAYDKFKDK
        70         80         90        100        110        120
RVGTKGLDFS DRIGKTKRTG YESGEYEMLG EGLGVKETPQ QKYQRLLHEV QELTTEVEKI
       130        140        150        160        170        180
KTTVKESATE EKLTPVLLAK QLAALKQQLV ASHLEKLLGP DAAINLTDPD GALAKRLLLQ
       190        200        210        220        230        240
LEATKNSKGG SGGKTTGTPP DSSLVTYELH SRPEQDKFSQ AAKVAELEKR LTELETAVRC
       250        260        270        280        290        300
DQDAQNPLSA GLQGACLMET VELLQAKVSA LDLAVLDQVE ARLQSVLGKV NEIAKHKASV
       310        320        330        340        350        360
EDADTQSKVH QLYETIQRWS PIASTLPELV QRLVTIKQLH EQAMQFGQLL THLDTTQQMI
       370        380        390        400
ANSLKDNTTL LTQVQTTMRE NLATVEGNFA SIDERMKKLG K         10         20         30         40         50         60
MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP NAAYDKFKDK
        70         80         90        100        110        120
RVGTKGLDFS DRIGKTKRTG YESGEYEMLG EGLGVKETPQ QKYQRLLHEV QELTTEVEKI
       130        140        150        160        170        180
KTTVKESATE EKLTPVLLAK QLAALKQQLV ASHLEKLLGP DAAINLTDPD GALAKRLLLQ
       190        200        210        220        230        240
LEATKNSKGG SGGKTTGTPP DSSLVTYELH SRPEQDKFSQ AAKVAELEKR LTELETAVRC
       250        260        270        280        290        300
DQDAQNPLSA GLQGACLMET VELLQAKVSA LDLAVLDQVE ARLQSVLGKV NEIAKHKASV
       310        320        330        340        350        360
EDADTQSKVH QLYETIQRWS PIASTLPELV QRLVTIKQLH EQAMQFGQLL THLDTTQQMI
       370        380        390        400
ANSLKDNTTL LTQVQTTMRE NLATVEGNFA SIDERMKKLG K

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13561-1-unknown	MADPKY...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72487
Q13561-1-unknown	MADPKY...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72488
Q13561-2-unknown	MADPKY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13561-2-Acetylation	ADPKYA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13561-2-Acetylation	ADPKYA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13561-2-Acetylation	ADPKYA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13561-2-Acetylation	ADPKYA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110643
Q13561-2-Acetylation	ADPKYA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110644
Q13561-36-unknown	EELTST...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19465
Q13561-36-unknown	EELTST...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17912
Q13561-36-unknown	EELTST...	36		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195778
Q13561-36-unknown	EELTST...	36		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195779
Q13561-109-unknown	EVQELT...	109		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6344
Q13561-109-unknown	EVQELT...	109		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143026
Q13561-109-unknown	EVQELT...	109		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143196
Q13561-162-unknown	AAINLT...	162		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12094
Q13561-162-unknown	AAINLT...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145296
Q13561-162-unknown	AAINLT...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145408

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...AEFDAE	35	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19465
...AEFDAE	35	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17912
...AEFDAE	35	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt153776
...AEFDAE	35	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt153777
...QRLLHE	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6344
...QRLLHE	108	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt126243
...QRLLHE	108	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt126422
...LLGPDA	161	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12094
...LLGPDA	161	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128587
...LLGPDA	161	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128701
...KKLGK	401		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KKLGK	401		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KKLGK	401	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KKLGK	401	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68106
...KKLGK	401	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68105
...KKLGK	401		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KKLGK	401		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	35	FDAE.\|.EELT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	35	FDAE.\|.EELT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	108	LLHE.\|.EVQE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	161	GPDA.\|.AAIN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)