P55327: Tumor protein D52

General Information

Protein names	- Tumor protein D52 - Protein N8
Gene names	TPD52
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P55327

27 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tumor protein D52 - Isoform 3 of Tumor protein D52 - Isoform 4 of Tumor protein D52 - Isoform 5 of Tumor protein D52 - Isoform 6 of Tumor protein D52 - Isoform 7 of Tumor protein D52 - Isoform 8 of Tumor protein D52

Sequence View

        10         20         30         40         50         60
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED
        70         80         90        100        110        120
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK
       130        140        150        160        170        180
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK
       190        200        210        220
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL         10         20         30         40         50         60
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED
        70         80         90        100        110        120
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK
       130        140        150        160        170        180
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK
       190        200        210        220
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL         10         20         30         40         50         60
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED
        70         80         90        100        110        120
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK
       130        140        150        160        170        180
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK
       190        200        210        220
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL         10         20         30         40         50         60
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED
        70         80         90        100        110        120
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK
       130        140        150        160        170        180
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK
       190        200        210        220
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL         10         20         30         40         50         60
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED
        70         80         90        100        110        120
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK
       130        140        150        160        170        180
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK
       190        200        210        220
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL         10         20         30         40         50         60
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED
        70         80         90        100        110        120
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK
       130        140        150        160        170        180
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK
       190        200        210        220
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL         10         20         30         40         50         60
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED
        70         80         90        100        110        120
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK
       130        140        150        160        170        180
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK
       190        200        210        220
VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

27 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P55327-1-unknown	MDCREM...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55327-1-unknown	MDCREM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92823
P55327-1-unknown	MDCREM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92824
P55327-1-unknown	MDCREM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92825
P55327-1-unknown	MDCREM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92826
P55327-88-unknown	EEIQTL...	88	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19214
P55327-88-unknown	EEIQTL...	88	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138947
P55327-88-unknown	EEIQTL...	88	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138948
P55327-88-unknown	EEIQTL...	88	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141687
P55327-88-unknown	EEIQTL...	88	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141690
P55327-88-unknown	EEIQTL...	88	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141692
P55327-88-unknown	EEIQTL...	88	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141693
P55327-88-unknown	EEIQTL...	88	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143039
P55327-98-unknown	AAKEKH...	98		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P55327-98-unknown	AAKEKH...	98	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162245
P55327-98-unknown	AAKEKH...	98	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162247
P55327-98-unknown	AAKEKH...	98	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162241
P55327-98-unknown	AAKEKH...	98	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162242
P55327-98-unknown	AAKEKH...	98	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162243
P55327-98-unknown	AAKEKH...	98	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162244
P55327-98-unknown	AAKEKH...	98	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162246
P55327-126-unknown	GWQDVT...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164273
P55327-126-unknown	GWQDVT...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164275
P55327-126-unknown	GWQDVT...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164270
P55327-126-unknown	GWQDVT...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164271
P55327-126-unknown	GWQDVT...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164272
P55327-126-unknown	GWQDVT...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164274
P55327-126-	GWQDVT...	126		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P55327-138-unknown	KTSETL...	138	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164266
P55327-138-unknown	KTSETL...	138	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164268
P55327-138-unknown	KTSETL...	138	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164263
P55327-138-unknown	KTSETL...	138	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164264
P55327-138-unknown	KTSETL...	138	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164265
P55327-138-unknown	KTSETL...	138	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164267
P55327-138-	KTSETL...	138		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P55327-138-	KTSETL...	138		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P55327-138-	KTSETL...	138		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P55327-139-unknown	TSETLS...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164259
P55327-139-unknown	TSETLS...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164261
P55327-139-unknown	TSETLS...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164256
P55327-139-unknown	TSETLS...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164257
P55327-139-unknown	TSETLS...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164258
P55327-139-unknown	TSETLS...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164260
P55327-139-	TSETLS...	139		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P55327-139-	TSETLS...	139		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P55327-159-	SVITKK...	159		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P55327-159-unknown	SVITKK...	159	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167469
P55327-159-unknown	SVITKK...	159	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167468
P55327-164-	KLEDVK...	164		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P55327-164-unknown	KLEDVK...	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165441
P55327-164-unknown	KLEDVK...	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165440
P55327-170-unknown	NSPTFK...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165448
P55327-170-unknown	NSPTFK...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165446
P55327-170-unknown	NSPTFK...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165443
P55327-170-unknown	NSPTFK...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165445
P55327-170-unknown	NSPTFK...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165444
P55327-170-unknown	NSPTFK...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165447
P55327-170-	NSPTFK...	170		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P55327-170-	NSPTFK...	170		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P55327-176-	SFEEKV...	176		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P55327-176-unknown	SFEEKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165455
P55327-176-unknown	SFEEKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165453
P55327-176-unknown	SFEEKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165450
P55327-176-unknown	SFEEKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165452
P55327-176-unknown	SFEEKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165451
P55327-176-unknown	SFEEKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165454
P55327-186-	SKVGGT...	186		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P55327-186-unknown	SKVGGT...	186	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165438
P55327-186-unknown	SKVGGT...	186	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165436
P55327-186-unknown	SKVGGT...	186	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165433
P55327-186-unknown	SKVGGT...	186	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165435
P55327-186-unknown	SKVGGT...	186	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165434
P55327-186-unknown	SKVGGT...	186	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165437
P55327-190-	GTKPAG...	190		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P55327-190-unknown	GTKPAG...	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167466
P55327-190-unknown	GTKPAG...	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167464
P55327-190-unknown	GTKPAG...	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167461
P55327-190-unknown	GTKPAG...	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167463
P55327-190-unknown	GTKPAG...	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167462
P55327-190-unknown	GTKPAG...	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167465
P55327-204-	SAANAS...	204		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55327-204-	SAANAS...	204		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P55327-204-unknown	SAANAS...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175231
P55327-204-unknown	SAANAS...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175229
P55327-204-unknown	SAANAS...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175226
P55327-204-unknown	SAANAS...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175228
P55327-204-unknown	SAANAS...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175227
P55327-204-unknown	SAANAS...	204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175230
P55327-208-	ASATTT...	208		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55327-208-unknown	ASATTT...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175238
P55327-208-unknown	ASATTT...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175236
P55327-208-unknown	ASATTT...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175233
P55327-208-unknown	ASATTT...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175235
P55327-208-unknown	ASATTT...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175234
P55327-208-unknown	ASATTT...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175237
P55327-209-	SATTTE...	209		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55327-209-unknown	SATTTE...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175245
P55327-209-unknown	SATTTE...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175243
P55327-209-unknown	SATTTE...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175240
P55327-209-unknown	SATTTE...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175242
P55327-209-unknown	SATTTE...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175241
P55327-209-unknown	SATTTE...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175244

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LAKVEE	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19214
...LAKVEE	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122014
...LAKVEE	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122015
...LAKVEE	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124869
...LAKVEE	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124872
...LAKVEE	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124874
...LAKVEE	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124875
...LAKVEE	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126258
...TQESL	224	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TQESL	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88438
...TQESL	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88440
...TQESL	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88443
...TQESL	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88441
...TQESL	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88442
...TQESL	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88439

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	87	KVEE.\|.EEIQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)