P31942: Heterogeneous nuclear ribonucleoprotein H3

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein H3 - hnRNP H3 - Heterogeneous nuclear ribonucleoprotein 2H9 - hnRNP 2H9
Gene names	HNRNPH3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P31942

26 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Heterogeneous nuclear ribonucleoprotein H3 - Isoform 3 of Heterogeneous nuclear ribonucleoprotein H3 - Isoform 4 of Heterogeneous nuclear ribonucleoprotein H3 - Isoform 5 of Heterogeneous nuclear ribonucleoprotein H3 - Isoform 6 of Heterogeneous nuclear ribonucleoprotein H3

Sequence View

        10         20         30         40         50         60
MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM DYQGRSTGEA
        70         80         90        100        110        120
FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY DPPRRLLGQR PGPYDRPIGG
       130        140        150        160        170        180
RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG
       190        200        210        220        230        240
YGGAGDASSG FHGGHFVHMR GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE
       250        260        270        280        290        300
FVTHEDAVAA MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG
       310        320        330        340
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY         10         20         30         40         50         60
MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM DYQGRSTGEA
        70         80         90        100        110        120
FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY DPPRRLLGQR PGPYDRPIGG
       130        140        150        160        170        180
RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG
       190        200        210        220        230        240
YGGAGDASSG FHGGHFVHMR GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE
       250        260        270        280        290        300
FVTHEDAVAA MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG
       310        320        330        340
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY         10         20         30         40         50         60
MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM DYQGRSTGEA
        70         80         90        100        110        120
FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY DPPRRLLGQR PGPYDRPIGG
       130        140        150        160        170        180
RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG
       190        200        210        220        230        240
YGGAGDASSG FHGGHFVHMR GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE
       250        260        270        280        290        300
FVTHEDAVAA MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG
       310        320        330        340
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY         10         20         30         40         50         60
MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM DYQGRSTGEA
        70         80         90        100        110        120
FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY DPPRRLLGQR PGPYDRPIGG
       130        140        150        160        170        180
RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG
       190        200        210        220        230        240
YGGAGDASSG FHGGHFVHMR GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE
       250        260        270        280        290        300
FVTHEDAVAA MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG
       310        320        330        340
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY         10         20         30         40         50         60
MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM DYQGRSTGEA
        70         80         90        100        110        120
FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY DPPRRLLGQR PGPYDRPIGG
       130        140        150        160        170        180
RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG
       190        200        210        220        230        240
YGGAGDASSG FHGGHFVHMR GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE
       250        260        270        280        290        300
FVTHEDAVAA MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG
       310        320        330        340
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

26 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P31942-1-unknown	MDWVMK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77144
P31942-1-Acetylation	MDWVMK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31942-1-Acetylation	MDWVMK...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P31942-1-Acetylation	MDWVMK...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31942-1-Acetylation	MDWVMK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101277
P31942-50-unknown	MDYQGR...	50		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77145
P31942-50-unknown	MDYQGR...	50		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100946
P31942-65-unknown	ASKEIA...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177892
P31942-65-unknown	ASKEIA...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177893
P31942-65-	ASKEIA...	65			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31942-132-unknown	MYDRMR...	132		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77146
P31942-132-unknown	MYDRMR...	132		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77147
P31942-132-unknown	MYDRMR...	132		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101001
P31942-145-	GGYGGF...	145			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31942-145-	GGYGGF...	145			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31942-145-	GGYGGF...	145			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31942-145-unknown	GGYGGF...	145		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170130
P31942-145-unknown	GGYGGF...	145		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170131
P31942-145-unknown	GGYGGF...	145		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170132
P31942-148-	GGFDDY...	148			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31942-148-unknown	GGFDDY...	148		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174903
P31942-148-unknown	GGFDDY...	148		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174904
P31942-148-unknown	GGFDDY...	148		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174905
P31942-148-unknown	GGFDDY...	148		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174906
P31942-148-unknown	GGFDDY...	148		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174907
P31942-149-	GFDDYG...	149			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31942-149-unknown	GFDDYG...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174909
P31942-149-unknown	GFDDYG...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174910
P31942-149-unknown	GFDDYG...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174911
P31942-149-unknown	GFDDYG...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174912
P31942-149-unknown	GFDDYG...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174913
P31942-158-	NYGYGN...	158			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31942-158-unknown	NYGYGN...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172672
P31942-158-unknown	NYGYGN...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172673
P31942-158-unknown	NYGYGN...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172674
P31942-158-unknown	NYGYGN...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172675
P31942-158-unknown	NYGYGN...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172676
P31942-160-	GYGNDG...	160			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P31942-160-	GYGNDG...	160			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P31942-160-	GYGNDG...	160			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31942-160-	GYGNDG...	160			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31942-160-unknown	GYGNDG...	160			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P31942-160-unknown	GYGNDG...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161639
P31942-160-unknown	GYGNDG...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161640
P31942-160-unknown	GYGNDG...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161641
P31942-160-unknown	GYGNDG...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161642
P31942-160-unknown	GYGNDG...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161643
P31942-183-unknown	GAGDAS...	183		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7429
P31942-183-unknown	GAGDAS...	183		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5789
P31942-183-unknown	GAGDAS...	183		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138795
P31942-183-unknown	GAGDAS...	183		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139308
P31942-183-unknown	GAGDAS...	183		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139309
P31942-183-unknown	GAGDAS...	183		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144026
P31942-183-unknown	GAGDAS...	183		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145437
P31942-186-unknown	DASSGF...	186		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19037
P31942-186-unknown	DASSGF...	186		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17577
P31942-186-unknown	DASSGF...	186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139082
P31942-186-unknown	DASSGF...	186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139525
P31942-186-unknown	DASSGF...	186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139526
P31942-186-unknown	DASSGF...	186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144183
P31942-186-unknown	DASSGF...	186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145559
P31942-214-	FFSPLN...	214			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31942-214-unknown	FFSPLN...	214		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170134
P31942-214-unknown	FFSPLN...	214		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170135
P31942-214-unknown	FFSPLN...	214		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170136
P31942-214-unknown	FFSPLN...	214		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170137
P31942-214-unknown	FFSPLN...	214		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170138
P31942-224-	HIDIGA...	224			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31942-224-unknown	HIDIGA...	224		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173605
P31942-224-unknown	HIDIGA...	224		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173606
P31942-224-unknown	HIDIGA...	224		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173607
P31942-224-unknown	HIDIGA...	224		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173608
P31942-224-unknown	HIDIGA...	224		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173609
P31942-247-	AVAAMS...	247			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31942-247-unknown	AVAAMS...	247		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173601
P31942-247-unknown	AVAAMS...	247		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173602
P31942-247-unknown	AVAAMS...	247		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173603
P31942-269-unknown	STPGGG...	269		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177888
P31942-269-unknown	STPGGG...	269		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177889
P31942-269-unknown	STPGGG...	269		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177890
P31942-269-	STPGGG...	269			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GHGYGG	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7429
...GHGYGG	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5789
...GHGYGG	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121853
...GHGYGG	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122383
...GHGYGG	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122384
...GHGYGG	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127270
...GHGYGG	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128730
...YGGAGD	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19037
...YGGAGD	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17577
...YGGAGD	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122153
...YGGAGD	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122615
...YGGAGD	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122616
...YGGAGD	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127436
...YGGAGD	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128857
...WRGMY	346	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WRGMY	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72764
...WRGMY	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72763
...WRGMY	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72762

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	182	GYGG.\|.GAGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	182	GYGG.\|.GAGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	185	GAGD.\|.DASS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	185	GAGD.\|.DASS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)