P55072: Transitional endoplasmic reticulum ATPase

General Information

Protein names	- Transitional endoplasmic reticulum ATPase - TER ATPase - 3.6.4.6 {ECO:0000269\|PubMed:26471729} - 15S Mg(2+)-ATPase p97 subunit - Valosin-containing protein - VCP
Gene names	VCP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P55072

41 N-termini

29 C-termini

32 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ LFRGDTVLLK
        70         80         90        100        110        120
GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI SIQPCPDVKY GKRIHVLPID
       130        140        150        160        170        180
DTVEGITGNL FEVYLKPYFL EAYRPIRKGD IFLVRGGMRA VEFKVVETDP SPYCIVAPDT
       190        200        210        220        230        240
VIHCEGEPIK REDEEESLNE VGYDDIGGCR KQLAQIKEMV ELPLRHPALF KAIGVKPPRG
       250        260        270        280        290        300
ILLYGPPGTG KTLIARAVAN ETGAFFFLIN GPEIMSKLAG ESESNLRKAF EEAEKNAPAI
       310        320        330        340        350        360
IFIDELDAIA PKREKTHGEV ERRIVSQLLT LMDGLKQRAH VIVMAATNRP NSIDPALRRF
       370        380        390        400        410        420
GRFDREVDIG IPDATGRLEI LQIHTKNMKL ADDVDLEQVA NETHGHVGAD LAALCSEAAL
       430        440        450        460        470        480
QAIRKKMDLI DLEDETIDAE VMNSLAVTMD DFRWALSQSN PSALRETVVE VPQVTWEDIG
       490        500        510        520        530        540
GLEDVKRELQ ELVQYPVEHP DKFLKFGMTP SKGVLFYGPP GCGKTLLAKA IANECQANFI
       550        560        570        580        590        600
SIKGPELLTM WFGESEANVR EIFDKARQAA PCVLFFDELD SIAKARGGNI GDGGGAADRV
       610        620        630        640        650        660
INQILTEMDG MSTKKNVFII GATNRPDIID PAILRPGRLD QLIYIPLPDE KSRVAILKAN
       670        680        690        700        710        720
LRKSPVAKDV DLEFLAKMTN GFSGADLTEI CQRACKLAIR ESIESEIRRE RERQTNPSAM
       730        740        750        760        770        780
EVEEDDPVPE IRRDHFEEAM RFARRSVSDN DIRKYEMFAQ TLQQSRGFGS FRFPSGNQGG
       790        800
AGPSQGSGGG TGGSVYTEDN DDDLYG

Isoforms

Sequence View

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P55072-2-unknown	MASGAD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55072-2-	ASGADS...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P55072-2-Acetylation	ASGADS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55072-2-Acetylation	ASGADS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P55072-2-Acetylation	ASGADS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P55072-2-Acetylation	ASGADS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-37-	SVVSLS...	37			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P55072-37-	SVVSLS...	37			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P55072-37-	SVVSLS...	37			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55072-46-unknown	MDELQL...	46		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392088
P55072-46-unknown	MDELQL...	46		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399456
P55072-75-unknown	DTCSDE...	75		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2578
P55072-170-unknown	PSPYCI...	170		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2579
P55072-180-unknown	TVIHCE...	180		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2580
P55072-197-	SLNEVG...	197			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-200-	EVGYDD...	200			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-205-unknown	DIGGCR...	205		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2581
P55072-276-	SKLAGE...	276			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-308-unknown	AIAPKR...	308		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2582
P55072-308-unknown	AIAPKR...	308		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2869
P55072-308-unknown	AIAPKR...	308		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1919
P55072-324-acetylation	IVSQLL...	324	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-369-unknown	IGIPDA...	369		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2583
P55072-396-unknown	LEQVAN...	396		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2584
P55072-398-unknown	QVANET...	398		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7582
P55072-411-unknown	LAALCS...	411		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2585
P55072-416-	SEAALQ...	416			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-444-	SLAVTM...	444			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P55072-444-	SLAVTM...	444			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P55072-446-	AVTMDD...	446			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55072-451-unknown	DFRWAL...	451		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2586
P55072-495-unknown	YPVEHP...	495		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19211
P55072-495-unknown	YPVEHP...	495		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17739
P55072-495-unknown	YPVEHP...	495		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6046
P55072-504-unknown	LKFGMT...	504		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17740
P55072-505-unknown	KFGMTP...	505		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17741
P55072-506-unknown	FGMTPS...	506		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17742
P55072-506-unknown	FGMTPS...	506		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55072-506-unknown	FGMTPS...	506		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P55072-507-unknown	GMTPSK...	507		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17743
P55072-508-unknown	MTPSKG...	508		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17744
P55072-509-unknown	TPSKGV...	509		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17745
P55072-516-unknown	FYGPPG...	516		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17746
P55072-581-unknown	SIAKAR...	581		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2587
P55072-581-unknown	SIAKAR...	581		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2870
P55072-581-unknown	SIAKAR...	581		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1920
P55072-587-	GGNIGD...	587			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55072-587-	GGNIGD...	587			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-610-unknown	GMSTKK...	610		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2588
P55072-639-acetylation	LDQLIY...	639	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-670-unknown	VDLEFL...	670		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2589
P55072-684-unknown	GADLTE...	684		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7583
P55072-714-unknown	QTNPSA...	714		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13677
P55072-715-	TNPSAM...	715			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55072-726-unknown	DPVPEI...	726		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2590
P55072-727-unknown	PVPEIR...	727		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2591
P55072-794-	SVYTED...	794			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IVLSDD	74	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2578
...GGMRAV	160	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399456
...VVETDP	169	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2579
...IVAPDT	179	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2580
...EVGYDD	204	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2581
...VGYDDI	205	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392088
...IDELDA	307	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2582
...IDELDA	307	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2869
...IDELDA	307	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1919
...DREVDI	368	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2583
...ADDVDL	395	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2584
...DVDLEQ	397	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7582
...HVGADL	410	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2585
...AVTMDD	450	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2586
...QELVQY	494	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19211
...QELVQY	494	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17739
...QELVQY	494	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6046
...HPDKFL	503	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17740
...PDKFLK	504	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17741
...DKFLKF	505	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17742
...KFLKFG	506	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17743
...FLKFGM	507	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17744
...LKFGMT	508	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17745
...SKGVLF	515	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17746
...FDELDS	580	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2587
...FDELDS	580	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2870
...FDELDS	580	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1920
...LTEMDG	609	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2588
...PVAKDV	669	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2589
...TNGFSG	683	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7583
...RERERQ	713	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13677
...EVEEDD	725	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2590
...VEEDDP	726	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2591
...TEDNDD	801	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2592
...DDLYG	806	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DDLYG	806		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	74	LSDD.\|.DTCS	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	169	ETDP.\|.PSPY	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	179	APDT.\|.TVIH	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	204	GYDD.\|.DIGG	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	307	ELDA.\|.AIAP	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP7_HUMAN	307	ELDA.\|.AIAP	inferred from experiment	unknown	MEROPS	Park SG	Jang M et al.:Mining of caspase-7 substrates ... (C14.003)	18596415,
CASP3_HUMAN	307	ELDA.\|.AIAP	inferred from experiment	unknown	MEROPS	Park SG	Jang M et al.:Mining of caspase-7 substrates ... (C14.003)	18596415,
CASP6_HUMAN	368	EVDI.\|.IGIP	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	395	DVDL.\|.LEQV	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CATS_HUMAN	397	DLEQ.\|.QVAN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP6_HUMAN	410	GADL.\|.LAAL	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	450	TMDD.\|.DFRW	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
MEP1B_HUMAN	494	LVQY.\|.YPVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	494	LVQY.\|.YPVE	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
CATL1_HUMAN	494	LVQY.\|.YPVE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	503	DKFL.\|.LKFG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	504	KFLK.\|.KFGM	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	505	FLKF.\|.FGMT	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	506	LKFG.\|.GMTP	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	507	KFGM.\|.MTPS	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	508	FGMT.\|.TPSK	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	515	GVLF.\|.FYGP	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
CASP6_HUMAN	580	ELDS.\|.SIAK	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP7_HUMAN	580	ELDS.\|.SIAK	inferred from experiment	unknown	MEROPS	Park SG	Jang M et al.:Mining of caspase-7 substrates ... (C14.003)	18596415,
CASP3_HUMAN	580	ELDS.\|.SIAK	inferred from experiment	unknown	MEROPS	Park SG	Jang M et al.:Mining of caspase-7 substrates ... (C14.003)	18596415,
CASP6_HUMAN	609	EMDG.\|.GMST	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	669	AKDV.\|.VDLE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CATS_HUMAN	683	GFSG.\|.GADL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAK_HUMAN	713	RERQ.\|.QTNP	inferred from experiment	unknown	MEROPS	Fan Z	Guo Y et al.:Valosin-containing protein clea... (S01.146)	20876349,
CASP6_HUMAN	725	EEDD.\|.DPVP	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	726	EDDP.\|.PVPE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	801	DNDD.\|.DDLY	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

TopFIND

P55072: Transitional endoplasmic reticulum ATPase

General Information

41

N-termini

29

C-termini

32

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

41 N-termini - 29 C-termini - 32 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates