O43290: U4/U6.U5 tri-snRNP-associated protein 1

General Information

Protein names	- U4/U6.U5 tri-snRNP-associated protein 1 - SNU66 homolog - hSnu66 - Squamous cell carcinoma antigen recognized by T-cells 1 - SART-1 - hSART-1 - U4/U6.U5 tri-snRNP-associated 110 kDa protein - Hom s 1
Gene names	SART1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43290

18 N-termini

11 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGSSKKHRGE KEAAGTTAAA GTGGATEQPP RHREHKKHKH RSGGSGGSGG ERRKRSRERG
        70         80         90        100        110        120
GERGSGRRGA EAEARSSTHG RERSQAEPSE RRVKREKRDD GYEAAASSKT SSGDASSLSI
       130        140        150        160        170        180
EETNKLRAKL GLKPLEVNAI KKEAGTKEEP VTADVINPMA LRQREELREK LAAAKEKRLL
       190        200        210        220        230        240
NQKLGKIKTL GEDDPWLDDT AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE
       250        260        270        280        290        300
FGQRRQDLYS ARDLQGLTVE HAIDSFREGE TMILTLKDKG VLQEEEDVLV NVNLVDKERA
       310        320        330        340        350        360
EKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILSKYDEE LEGERPHSFR LEQGGTADGL
       370        380        390        400        410        420
RERELEEIRA KLRLQAQSLS TVGPRLASEY LTPEEMVTFK KTKRRVKKIR KKEKEVVVRA
       430        440        450        460        470        480
DDLLPLGDQT QDGDFGSRLR GRGRRRVSEV EEEKEPVPQP LPSDDTRVEN MDISDEEEGG
       490        500        510        520        530        540
APPPGSPQVL EEDEAELELQ KQLEKGRRLR QLQQLQQLRD SGEKVVEIVK KLESRQRGWE
       550        560        570        580        590        600
EDEDPERKGA IVFNATSEFC RTLGEIPTYG LAGNREEQEE LMDFERDEER SANGGSESDG
       610        620        630        640        650        660
EENIGWSTVN LDEEKQQQDF SASSTTILDE EPIVNRGLAA ALLLCQNKGL LETTVQKVAR
       670        680        690        700        710        720
VKAPNKSLPS AVYCIEDKMA IDDKYSRREE YRGFTQDFKE KDGYKPDVKI EYVDETGRKL
       730        740        750        760        770        780
TPKEAFRQLS HRFHGKGSGK MKTERRMKKL DEEALLKKMS SSDTPLGTVA LLQEKQKAQK
       790        800
TPYIVLSGSG KSMNANTITK

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 11 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43290-1-unknown	MGSSKK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43290-19-unknown	AAGTGG...	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9880
O43290-21-unknown	GTGGAT...	21	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3268
O43290-155-unknown	VINPMA...	155	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10734
O43290-172-unknown	AAAKEK...	172	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13747
O43290-231-unknown	FGVSTL...	231	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10735
O43290-235-unknown	TLVEEE...	235	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10736
O43290-258-unknown	TVEHAI...	258	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13748
O43290-265-	SFREGE...	265		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43290-332-	SILSKY...	332		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43290-395-unknown	EMVTFK...	395	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10737
O43290-422-unknown	DLLPLG...	422	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10738
O43290-427-unknown	GDQTQD...	427		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O43290-427-	GDQTQD...	427		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O43290-493-unknown	DEAELE...	493	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18229
O43290-624-	STTILD...	624		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43290-749-unknown	KLDEEA...	749		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O43290-749-	KLDEEA...	749		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AGTTAA	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9880
...TTAAAG	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3268
...PVTADV	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10734
...LREKLA	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13747
...EMDQEF	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10735
...EFGVST	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10736
...DLQGLT	257	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13748
...YLTPEE	394	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10737
...VVRADD	421	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10738
...QVLEED	492	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18229
...NTITK	800	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	18	TTAA.\|.AAGT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATB_HUMAN	20	AAAG.\|.GTGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	154	TADV.\|.VINP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	171	EKLA.\|.AAAK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	230	DQEF.\|.FGVS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	234	GVST.\|.TLVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	257	QGLT.\|.TVEH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	394	TPEE.\|.EMVT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	421	RADD.\|.DLLP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	492	LEED.\|.DEAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)