O75822: Eukaryotic translation initiation factor 3 subunit J {ECO:0000255|HAMAP-Rule:MF_03009}

General Information

Protein names	- Eukaryotic translation initiation factor 3 subunit J {ECO:0000255\|HAMAP-Rule:MF_03009} - eIF3j {ECO:0000255\|HAMAP-Rule:MF_03009} - Eukaryotic translation initiation factor 3 subunit 1 {ECO:0000255\|HAMAP-Rule:MF_03009} - eIF-3-alpha {ECO:0000255\|HAMAP-Rule:MF_03009} - eIF3 p35 {ECO:0000255\|HAMAP-Rule:MF_03009}
Gene names	EIF3J
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75822

20 N-termini

8 C-termini

10 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 3 subunit J - Isoform 3 of Eukaryotic translation initiation factor 3 subunit J

Sequence View

        10         20         30         40         50         60
MAAAAAAAGD SDSWDADAFS VEDPVRKVGG GGTAGGDRWE GEDEDEDVKD NWDDDDDEKK
        70         80         90        100        110        120
EEAEVKPEVK ISEKKKIAEK IKEKERQQKK RQEEIKKRLE EPEEPKVLTP EEQLADKLRL
       130        140        150        160        170        180
KKLQEESDLE LAKETFGVNN AVYGIDAMNP SSRDDFTEFG KLLKDKITQY EKSLYYASFL
       190        200        210        220        230        240
EVLVRDVCIS LEIDDLKKIT NSLTVLCSEK QKQEKQSKAK KKKKGVVPGG GLKATMKDDL
       250
ADYGGYDGGY VQDYEDFM         10         20         30         40         50         60
MAAAAAAAGD SDSWDADAFS VEDPVRKVGG GGTAGGDRWE GEDEDEDVKD NWDDDDDEKK
        70         80         90        100        110        120
EEAEVKPEVK ISEKKKIAEK IKEKERQQKK RQEEIKKRLE EPEEPKVLTP EEQLADKLRL
       130        140        150        160        170        180
KKLQEESDLE LAKETFGVNN AVYGIDAMNP SSRDDFTEFG KLLKDKITQY EKSLYYASFL
       190        200        210        220        230        240
EVLVRDVCIS LEIDDLKKIT NSLTVLCSEK QKQEKQSKAK KKKKGVVPGG GLKATMKDDL
       250
ADYGGYDGGY VQDYEDFM

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

20 N-termini - 8 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75822-1-unknown	MAAAAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73768
O75822-1-unknown	MAAAAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73769
O75822-2-unknown	MAAAAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75822-2-unknown	MAAAAA...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O75822-2-unknown	MAAAAA...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O75822-2-Acetylation	AAAAAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75822-2-Acetylation	AAAAAA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O75822-2-Acetylation	AAAAAA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O75822-2-Acetylation	AAAAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111255
O75822-2-Acetylation	AAAAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111256
O75822-7-unknown	AAGDSD...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175360
O75822-7-unknown	AAGDSD...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175361
O75822-7-	AAGDSD...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75822-16-unknown	ADAFSV...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175357
O75822-16-unknown	ADAFSV...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175358
O75822-16-	ADAFSV...	16			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75822-18-unknown	AFSVED...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1115
O75822-18-unknown	AFSVED...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3214
O75822-18-unknown	AFSVED...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10967
O75822-18-unknown	AFSVED...	18		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136710
O75822-18-unknown	AFSVED...	18		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136711
O75822-18-	AFSVED...	18			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75822-18-	AFSVED...	18			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75822-19-unknown	FSVEDP...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165584
O75822-19-unknown	FSVEDP...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165585
O75822-19-	FSVEDP...	19			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75822-38-unknown	RWEGED...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10970
O75822-38-unknown	RWEGED...	38		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138215
O75822-51-unknown	NWDDDD...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165582
O75822-51-	NWDDDD...	51			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75822-51-	NWDDDD...	51			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75822-51-	NWDDDD...	51			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75822-69-unknown	VKISEK...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10973
O75822-69-unknown	VKISEK...	69		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140588
O75822-101-unknown	EPEEPK...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16970
O75822-101-unknown	EPEEPK...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18320
O75822-101-unknown	EPEEPK...	101		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142447
O75822-101-unknown	EPEEPK...	101		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196967
O75822-140-unknown	NAVYGI...	140		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10975
O75822-140-unknown	NAVYGI...	140		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141908
O75822-141-unknown	AVYGID...	141		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175355
O75822-141-	AVYGID...	141			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75822-243-unknown	YGGYDG...	243		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1497
O75822-243-unknown	YGGYDG...	243		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146228
O75822-243-unknown	YGGYDG...	243		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146405

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SWDADA	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1115
...SWDADA	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3214
...SWDADA	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10967
...TAGGDR	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10970
...TAGGDR	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121243
...TAGGDR	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121244
...EVKPEV	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10973
...EVKPEV	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123722
...KKRLEE	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16970
...KKRLEE	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18320
...KKRLEE	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125641
...TFGVNN	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10975
...TFGVNN	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125088
...DDLADY	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1497
...DDLADY	242	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129532
...DDLADY	242	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129710
...QDYEDF	256	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1500
...QDYEDF	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129964
...QDYEDF	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130189
...YEDFM	258	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YEDFM	258	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69386
...YEDFM	258	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69387

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	17	DADA.\|.AFSV	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CASPE_HUMAN	17	DADA.\|.AFSV	inferred from experiment	unknown	MEROPS		Merops CASPE_HUMAN -> EIF3J_HUMAN @17
GRAB_HUMAN	17	DADA.\|.AFSV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	37	GGDR.\|.RWEG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	68	KPEV.\|.VKIS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1A_HUMAN	100	RLEE.\|.EPEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	100	RLEE.\|.EPEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	139	GVNN.\|.NAVY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP3_HUMAN	242	LADY.\|.YGGY	inferred from experiment	unknown	MEROPS	Morley SJ	Bushell M et al.:Changes in integrity and associ... (C14.003)	10672017,
CASP3_HUMAN	256	YEDF.\|.FM	inferred from experiment	unknown	MEROPS	Morley SJ	Bushell M et al.:Changes in integrity and associ... (C14.003)	10672017,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)