P35580: Myosin-10
Protein names | - Myosin-10 - Cellular myosin heavy chain, type B - Myosin heavy chain 10 - Myosin heavy chain, non-muscle IIb - Non-muscle myosin heavy chain B - NMMHC-B - Non-muscle myosin heavy chain IIb - NMMHC II-b - NMMHC-IIB |
---|---|
Gene names | MYH10 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P35580 |
14
N-termini
7
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV
70 80 90 100 110 120
ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL
130 140 150 160 170 180
FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES
190 200 210 220 230 240
GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS
250 260 270 280 290 300
RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL
310 320 330 340 350 360
LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS
370 380 390 400 410 420
FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA
430 440 450 460 470 480
VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN
490 500 510 520 530 540
EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW
550 560 570 580 590 600
FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN
610 620 630 640 650 660
DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES
670 680 690 700 710 720
LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV
730 740 750 760 770 780
FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE
790 800 810 820 830 840
ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK
850 860 870 880 890 900
VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET
910 920 930 940 950 960
ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD
970 980 990 1000 1010 1020
EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE
1030 1040 1050 1060 1070 1080
KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE
1090 1100 1110 1120 1130 1140
LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ
1150 1160 1170 1180 1190 1200
KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR
1210 1220 1230 1240 1250 1260
HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ
1270 1280 1290 1300 1310 1320
VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT
1330 1340 1350 1360 1370 1380
QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV
1390 1400 1410 1420 1430 1440
DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR
1450 1460 1470 1480 1490 1500
QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550 1560
EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED
1570 1580 1590 1600 1610 1620
AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK
1630 1640 1650 1660 1670 1680
KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK
1690 1700 1710 1720 1730 1740
KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ
1750 1760 1770 1780 1790 1800
LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK
1810 1820 1830 1840 1850 1860
LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED
1870 1880 1890 1900 1910 1920
ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE
1930 1940 1950 1960 1970
VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE
Isoforms
- Isoform 2 of Myosin-10 - Isoform 3 of Myosin-10 - Isoform 4 of Myosin-10 - Isoform 5 of Myosin-10Sequence View
10 20 30 40 50 60
MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV
70 80 90 100 110 120
ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL
130 140 150 160 170 180
FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES
190 200 210 220 230 240
GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS
250 260 270 280 290 300
RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL
310 320 330 340 350 360
LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS
370 380 390 400 410 420
FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA
430 440 450 460 470 480
VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN
490 500 510 520 530 540
EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW
550 560 570 580 590 600
FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN
610 620 630 640 650 660
DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES
670 680 690 700 710 720
LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV
730 740 750 760 770 780
FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE
790 800 810 820 830 840
ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK
850 860 870 880 890 900
VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET
910 920 930 940 950 960
ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD
970 980 990 1000 1010 1020
EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE
1030 1040 1050 1060 1070 1080
KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE
1090 1100 1110 1120 1130 1140
LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ
1150 1160 1170 1180 1190 1200
KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR
1210 1220 1230 1240 1250 1260
HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ
1270 1280 1290 1300 1310 1320
VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT
1330 1340 1350 1360 1370 1380
QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV
1390 1400 1410 1420 1430 1440
DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR
1450 1460 1470 1480 1490 1500
QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550 1560
EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED
1570 1580 1590 1600 1610 1620
AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK
1630 1640 1650 1660 1670 1680
KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK
1690 1700 1710 1720 1730 1740
KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ
1750 1760 1770 1780 1790 1800
LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK
1810 1820 1830 1840 1850 1860
LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED
1870 1880 1890 1900 1910 1920
ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE
1930 1940 1950 1960 1970
VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE
10 20 30 40 50 60
MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV
70 80 90 100 110 120
ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL
130 140 150 160 170 180
FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES
190 200 210 220 230 240
GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS
250 260 270 280 290 300
RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL
310 320 330 340 350 360
LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS
370 380 390 400 410 420
FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA
430 440 450 460 470 480
VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN
490 500 510 520 530 540
EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW
550 560 570 580 590 600
FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN
610 620 630 640 650 660
DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES
670 680 690 700 710 720
LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV
730 740 750 760 770 780
FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE
790 800 810 820 830 840
ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK
850 860 870 880 890 900
VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET
910 920 930 940 950 960
ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD
970 980 990 1000 1010 1020
EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE
1030 1040 1050 1060 1070 1080
KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE
1090 1100 1110 1120 1130 1140
LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ
1150 1160 1170 1180 1190 1200
KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR
1210 1220 1230 1240 1250 1260
HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ
1270 1280 1290 1300 1310 1320
VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT
1330 1340 1350 1360 1370 1380
QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV
1390 1400 1410 1420 1430 1440
DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR
1450 1460 1470 1480 1490 1500
QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550 1560
EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED
1570 1580 1590 1600 1610 1620
AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK
1630 1640 1650 1660 1670 1680
KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK
1690 1700 1710 1720 1730 1740
KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ
1750 1760 1770 1780 1790 1800
LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK
1810 1820 1830 1840 1850 1860
LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED
1870 1880 1890 1900 1910 1920
ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE
1930 1940 1950 1960 1970
VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE
10 20 30 40 50 60
MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV
70 80 90 100 110 120
ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL
130 140 150 160 170 180
FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES
190 200 210 220 230 240
GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS
250 260 270 280 290 300
RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL
310 320 330 340 350 360
LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS
370 380 390 400 410 420
FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA
430 440 450 460 470 480
VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN
490 500 510 520 530 540
EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW
550 560 570 580 590 600
FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN
610 620 630 640 650 660
DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES
670 680 690 700 710 720
LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV
730 740 750 760 770 780
FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE
790 800 810 820 830 840
ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK
850 860 870 880 890 900
VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET
910 920 930 940 950 960
ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD
970 980 990 1000 1010 1020
EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE
1030 1040 1050 1060 1070 1080
KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE
1090 1100 1110 1120 1130 1140
LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ
1150 1160 1170 1180 1190 1200
KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR
1210 1220 1230 1240 1250 1260
HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ
1270 1280 1290 1300 1310 1320
VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT
1330 1340 1350 1360 1370 1380
QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV
1390 1400 1410 1420 1430 1440
DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR
1450 1460 1470 1480 1490 1500
QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550 1560
EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED
1570 1580 1590 1600 1610 1620
AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK
1630 1640 1650 1660 1670 1680
KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK
1690 1700 1710 1720 1730 1740
KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ
1750 1760 1770 1780 1790 1800
LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK
1810 1820 1830 1840 1850 1860
LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED
1870 1880 1890 1900 1910 1920
ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE
1930 1940 1950 1960 1970
VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE
10 20 30 40 50 60
MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV
70 80 90 100 110 120
ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL
130 140 150 160 170 180
FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES
190 200 210 220 230 240
GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS
250 260 270 280 290 300
RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL
310 320 330 340 350 360
LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS
370 380 390 400 410 420
FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA
430 440 450 460 470 480
VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN
490 500 510 520 530 540
EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW
550 560 570 580 590 600
FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN
610 620 630 640 650 660
DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES
670 680 690 700 710 720
LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV
730 740 750 760 770 780
FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE
790 800 810 820 830 840
ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK
850 860 870 880 890 900
VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET
910 920 930 940 950 960
ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD
970 980 990 1000 1010 1020
EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE
1030 1040 1050 1060 1070 1080
KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE
1090 1100 1110 1120 1130 1140
LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ
1150 1160 1170 1180 1190 1200
KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR
1210 1220 1230 1240 1250 1260
HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ
1270 1280 1290 1300 1310 1320
VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT
1330 1340 1350 1360 1370 1380
QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV
1390 1400 1410 1420 1430 1440
DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR
1450 1460 1470 1480 1490 1500
QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550 1560
EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED
1570 1580 1590 1600 1610 1620
AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK
1630 1640 1650 1660 1670 1680
KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK
1690 1700 1710 1720 1730 1740
KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ
1750 1760 1770 1780 1790 1800
LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK
1810 1820 1830 1840 1850 1860
LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED
1870 1880 1890 1900 1910 1920
ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE
1930 1940 1950 1960 1970
VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE
Protein Neighborhood
Domains & Features
14 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P35580-1-unknown | MAQRTG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P35580-1-unknown | MAQRTG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81952 | |||
P35580-1-unknown | MAQRTG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81953 | |||
P35580-1-unknown | MAQRTG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81954 | |||
P35580-221-unknown | ANPILE... | 221 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3778 | |||
P35580-221-unknown | ANPILE... | 221 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147402 | |||
P35580-221-unknown | ANPILE... | 221 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt198249 | |||
P35580-221-unknown | ANPILE... | 221 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt198250 | |||
P35580-222-unknown | NPILES... | 222 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19076 | |||
P35580-222-unknown | NPILES... | 222 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147441 | |||
P35580-222-unknown | NPILES... | 222 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt198258 | |||
P35580-222-unknown | NPILES... | 222 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt198259 | |||
P35580-950-unknown | AHIQDL... | 950 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171114 | |||
P35580-950-unknown | AHIQDL... | 950 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171113 | |||
P35580-950-unknown | AHIQDL... | 950 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171112 | |||
P35580-950- | AHIQDL... | 950 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P35580-1109-unknown | ALKVVR... | 1109 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11460 | |||
P35580-1109-unknown | ALKVVR... | 1109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157462 | |||
P35580-1109-unknown | ALKVVR... | 1109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157472 | |||
P35580-1109-unknown | ALKVVR... | 1109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157488 | |||
P35580-1161-unknown | TTAAQQ... | 1161 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1798 | |||
P35580-1161-unknown | TTAAQQ... | 1161 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157588 | |||
P35580-1161-unknown | TTAAQQ... | 1161 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157613 | |||
P35580-1161-unknown | TTAAQQ... | 1161 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157662 | |||
P35580-1161- | TTAAQQ... | 1161 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P35580-1161- | TTAAQQ... | 1161 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P35580-1259-unknown | AQVQEL... | 1259 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5813 | |||
P35580-1259-unknown | AQVQEL... | 1259 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157863 | |||
P35580-1259-unknown | AQVQEL... | 1259 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157871 | |||
P35580-1259-unknown | AQVQEL... | 1259 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157890 | |||
P35580-1292-unknown | VSTLLE... | 1292 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17614 | |||
P35580-1292-unknown | VSTLLE... | 1292 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157910 | |||
P35580-1292-unknown | VSTLLE... | 1292 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157916 | |||
P35580-1292-unknown | VSTLLE... | 1292 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157933 | |||
P35580-1310- | AASLES... | 1310 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P35580-1310-unknown | AASLES... | 1310 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171122 | |||
P35580-1310-unknown | AASLES... | 1310 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171121 | |||
P35580-1310-unknown | AASLES... | 1310 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171120 | |||
P35580-1347- | SLQEQQ... | 1347 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P35580-1347-unknown | SLQEQQ... | 1347 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171118 | |||
P35580-1347-unknown | SLQEQQ... | 1347 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171117 | |||
P35580-1347-unknown | SLQEQQ... | 1347 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171116 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...RQLLQA | 220 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3778 | |||
...RQLLQA | 220 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130749 | |||
...QLLQAN | 221 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19076 | |||
...QLLQAN | 221 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130791 | |||
...LHKNNA | 1108 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11460 | |||
...LHKNNA | 1108 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140960 | |||
...LHKNNA | 1108 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140970 | |||
...LHKNNA | 1108 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140986 | |||
...EDTLDT | 1160 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1798 | |||
...EDTLDT | 1160 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141087 | |||
...EDTLDT | 1160 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141112 | |||
...EDTLDT | 1160 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141161 | |||
...RKKLDA | 1258 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5813 | |||
...RKKLDA | 1258 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141360 | |||
...RKKLDA | 1258 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141368 | |||
...RKKLDA | 1258 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141387 | |||
...NELDNV | 1291 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17614 | |||
...NELDNV | 1291 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141405 | |||
...NELDNV | 1291 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141411 | |||
...NELDNV | 1291 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141430 | |||
...PPQSE | 1976 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...PPQSE | 1976 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77570 | |||
...PPQSE | 1976 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77571 | |||
...PPQSE | 1976 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77572 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATB_HUMAN | 220 | LLQA.|.ANPI | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
MEP1B_HUMAN | 221 | LQAN.|.NPIL | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
GRAB_HUMAN | 1108 | KNNA.|.ALKV | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
CASP3_HUMAN | 1160 | TLDT.|.TTAA | inferred from experiment | unknown | MEROPS | Merops CASP3_HUMAN -> MYH10_HUMAN @1160 | ||
CATL1_HUMAN | 1258 | KLDA.|.AQVQ | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
MEP1A_HUMAN | 1291 | LDNV.|.VSTL | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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