P62258: 14-3-3 protein epsilon

General Information

Protein names	- 14-3-3 protein epsilon - 14-3-3E
Gene names	YWHAE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62258

20 N-termini

8 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW
        70         80         90        100        110        120
RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF
       130        140        150        160        170        180
YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF
       190        200        210        220        230        240
YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE
       250
EQNKEALQDV EDENQ

Isoforms

- Isoform SV of 14-3-3 protein epsilon

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

20 N-termini - 8 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62258-1-Acetylation	MDDRED...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62258-1-Acetylation	MDDRED...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P62258-1-Acetylation	MDDRED...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62258-3-unknown	DREDLV...	3		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19255
P62258-5-Pyrrolidone carboxylic acid (Glu)	EDLVYQ...	5	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62258-5-	EDLVYQ...	5			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62258-5-acetylation	EDLVYQ...	5	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62258-23-unknown	MVESMK...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65720
P62258-62-unknown	IISSIE...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169960
P62258-62-	IISSIE...	62			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62258-70-unknown	EENKGG...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19256
P62258-70-unknown	EENKGG...	70		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138963
P62258-109-unknown	IPAANT...	109			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P62258-109-unknown	IPAANT...	109		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161236
P62258-134-unknown	EFATGN...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7636
P62258-134-unknown	EFATGN...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6109
P62258-134-unknown	EFATGN...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143087
P62258-135-unknown	FATGND...	135		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3882
P62258-135-unknown	FATGND...	135		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143108
P62258-155-unknown	ASDIAM...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170455
P62258-155-	ASDIAM...	155			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62258-155-	ASDIAM...	155			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P62258-155-	ASDIAM...	155			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62258-162-unknown	ELPPTH...	162		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7638
P62258-162-unknown	ELPPTH...	162		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6111
P62258-162-unknown	ELPPTH...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144321
P62258-178-unknown	SVFYYE...	178		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182854
P62258-178-	SVFYYE...	178			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62258-208-unknown	TLSEES...	208		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2608
P62258-208-unknown	TLSEES...	208		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146099
P62258-233-unknown	SDMQGD...	233		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6113
P62258-233-unknown	SDMQGD...	233		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147025
P62258-239-unknown	GEEQNK...	239		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1967
P62258-239-unknown	GEEQNK...	239		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11765
P62258-239-unknown	GEEQNK...	239		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147245

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SIEQKE	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19256
...SIEQKE	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122031
...HRYLAE	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7636
...HRYLAE	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6109
...HRYLAE	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126305
...RYLAEF	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3882
...RYLAEF	134	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126329
...DIAMTE	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7638
...DIAMTE	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6111
...DIAMTE	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127583
...IAELDT	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2608
...IAELDT	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129399
...LTLWTS	232	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6113
...LTLWTS	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130358
...DMQGDG	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1967
...DMQGDG	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11765
...DMQGDG	238	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130588
...EDENQ	255	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EDENQ	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61338

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	2	.\|.DRED	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	69	EQKE.\|.EENK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	133	YLAE.\|.EFAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	133	YLAE.\|.EFAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	134	LAEF.\|.FATG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	161	AMTE.\|.ELPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	161	AMTE.\|.ELPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP6_HUMAN	207	ELDT.\|.TLSE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CATL1_HUMAN	232	LWTS.\|.SDMQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	238	QGDG.\|.GEEQ	inferred from experiment	unknown	MEROPS	Joe CO	Won J et al.:Cleavage of 14-3-3 protein by c... (C14.003)	12657644,
GRAB_HUMAN	238	QGDG.\|.GEEQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)